How Tapping Works: Psychological and Neurobiological Mechanisms

David Feinstein^*

• Independent Practice, Other, Ashland, United States

Energy psychology protocols that incorporate tapping on acupuncture points—with Emotional Freedom Techniques (EFT) being the field's most widely studied and used format—are contributing to an integration of psychological and somatic approaches in the treatment of conditions including PTSD, anxiety, and depression. Once dismissed as fringe or implausible, tapping therapies are now at the center of a scientific reckoning as mounting clinical and physiological evidence challenges longstanding skepticism. This review synthesizes over two decades of research—including more than 200 clinical trials, meta-analyses, biomarker investigations, and dismantling studies—to provide a comprehensive assessment of both the efficacy and mechanisms underlying acupoint tapping. The clinical trials have consistently led to positive outcomes, often with unusual speed and strong durability. Neurobiological research reveals that tapping generates electrochemical signals which modulate limbic as well as executive brain regions. These interventions also produce measurable shifts in biomarkers— including reduced cortisol, enhanced immune function, and changes in gene expression—that correspond with clinical improvements. Dismantling studies show that acupoint stimulation is a vital, non-placebo component of the approach. In addition, theoretical and empirical advances suggest that tapping protocols efficiently facilitate memory reconsolidation, enabling the durable transformation of distressing memories and maladaptive mental models. By mapping a stepwise physiological cascade from tapping to symptom relief, this review bridges the gap between clinical observation and scientific explanation, clarifies priorities for future research, and supports the integration of energy psychology into evidence-based mental health care.