REVIEW article
Front. Psychol.
Sec. Psycho-Oncology
Medical Ozone Treatment for Pain, Fatigue, Anxiety, and Depression in Cancer Patients: A Scoping Review
Provisionally accepted
- Mianyang Central Hospital, Mianyang, China
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Aim: The aim of this study is to conduct a scoping review on the application of medical ozone treatment in managing symptoms(including Pain, Fatigue, Anxiety, and Depression) among cancer patients, aiming to provide clinical medical staff with a reference for implementing a novel approach to symptom management. Methods: This scoping review was conducted based on the methodology presented by Arksey and O'Malley and The Joanna BriggsInstitute methodology was employed to conduct scoped reviews of Pubmed,Web of science,CINAHL,EMBASE,MEDLINE,APA and CNKI in order to address the research question: "What is the impact of medical ozone treatment on pain, fatigue, anxiety,and depression in cancer patients?"Two independent reviewers select samples by screening and reviewing articles and extract data using a data chart form.The protocol wasregistered in the Open Science Framework (OSF.) Results: A total of sixteen articles were included to analyze and integrate the use of medical ozone, medical ozone dose, symptom assessment tools, and symptom management. Conclusion: The effectiveness of medical ozone treatment in managing key symptoms (including Pain, Fatigue, Anxiety, and Depression) among cancer patients has been preliminarily verified. Future studies need to cover a wider range of areas and larger sample sizes, as well as conduct long-term follow-up studies and multi-dimensional evaluation to enhance the universality and reliability of the results.
Keywords: Cancer, Medical Ozone Treatment, Symptoms, Scoping review, Ozone
Received: 18 Aug 2025; Accepted: 27 Oct 2025.
Copyright: © 2025 Lei, Xue, Feng, Wang and Jiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Lei Lei, vickylei1997@163.com
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