Is the MMSE enough for MCI? A Narrative Review of the usefulness of the MMSE

Giorgia D'Ignazio^1*Leonardo Carlucci²MARIA RITA SERGI¹Rocco Palumbo¹Laura Dattilo²Michela Terrei¹Michela Balsamo¹

• ¹University of Studies G. d'Annunzio Chieti and Pescara, Chieti, Italy
• ²Universita degli Studi di Foggia, Foggia, Italy

Background Mild Cognitive Impairment (MCI) is a clinical condition characterized by a decline in cognitive functions greater than expected for an individual's age and educational level, yet not severe enough to significantly interfere with daily activities. Early identification of MCI is crucial for targeted interventions, monitoring symptom progression, and implementing appropriate therapeutic or support strategies. In clinical practice, screening tools are often used that show clear limitations in sensitivity and in their ability to detect mild cognitive alterations. Methods Although the Mini-Mental State Examination (MMSE) is among the most widely used tools for initial assessment in non-specialist settings, it presents significant psychometric limitations in identifying MCI. A critical analysis of its effectiveness is therefore essential to guide an informed choice of assessment instruments Results: A narrative review of the literature suggests that the MMSE shows reduced sensitivity in detecting MCI, with a tendency to underestimate mild cognitive deficits. Specific cognitive domains are insufficiently captured by the MMSE compared to more sensitive tools. Conclusions: In light of these limitations, this review highlights the need to adopt alternative cognitive tests for the early detection of cognitive impairment.