%A Ni,Jiaying
%A Wang,Ping
%A Zheng,Tao
%A Lv,Long
%A Peng,Hao
%D 2021
%J Frontiers in Nutrition
%C
%F
%G English
%K Coffee,gestational diabetes mellitus,Meta-analysis,Systematic reveiw,Safety
%Q
%R 10.3389/fnut.2021.739359
%W
%L
%M
%P
%7
%8 2021-September-20
%9 Review
%#
%! Coffee and risk of gestational diabetes mellitus
%*
%<
%T Consumption of Coffee and Risk of Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis of Observational Studies
%U https://www.frontiersin.org/articles/10.3389/fnut.2021.739359
%V 8
%0 JOURNAL ARTICLE
%@ 2296-861X
%X Objective: The results from epidemiologic studies on the relationship between intake of coffee and the risk of gestational diabetes mellitus (GDM) remain inconclusive. A meta-analysis was performed to achieve a comprehensive finding regarding the association between intake of coffee and the risk of GDM.Methods: PubMed, Scopus, ISI Web of Science, and Google Scholar were searched to find articles published up to August 2021. Observational studies that reported risk estimates [risk ratios (RRs), hazard ratios (HRs), and odds ratios (ORs)] for the association of consumption of coffee with the risk of GDM in pregnant women were included. Random effects model was applied to calculate summarized risk estimate and 95% CIs for the highest vs. lowest categories of intake of coffee.Results: Seven observational studies (three cohort, two case-control, and two cross-sectional studies) with 75,607 participants and 1,625 women with GDM met the inclusion criteria. The meta-analysis of comparing the highest vs. lowest intake of coffee categories showed no significant association between intake of coffee and risk of GDM (summarized risk estimate: 0.89; 95% CI: 0.76, 1.05; I2 = 63.4%). Subgroup analysis showed that consumption of coffee had an inverse relationship with GDM in studies conducted in non-Asia countries (summarized risk estimate: 0.75; 95% CI: 0.58, 0.97; I2 = 6%).Conclusion: This study has shown that high consumption of coffee did not decrease the risk of GDM. Furthermore, large-scale cohort studies are required to confirm our findings.