# Polymerization Induces Non-Gaussian Diffusion

- Dipartimento di FIsica e Astronomia e Sezione INFN di Padova, Universita' di Padova, Padua, Italy

Recent theoretical modeling offers a unified picture for the description of stochastic processes characterized by a crossover from anomalous to normal behavior. This is particularly welcome, as a growing number of experiments suggest the crossover to be a common feature shared by many systems: in some cases the anomalous part of the dynamics amounts to a Brownian yet non-Gaussian diffusion; more generally, both the diffusion exponent and the distribution may deviate from normal behavior in the initial part of the process. Since proposed theories work at a mesoscopic scale invoking the subordination of diffusivities, it is of primary importance to bridge these representations with a more fundamental, “microscopic” description. We argue that the dynamical behavior of macromolecules during simple polymerization processes provide suitable setups in which analytic, numerical, and particle-tracking experiments can be contrasted at such a scope. Specifically, we demonstrate that Brownian yet non-Gaussian diffusion of the center of mass of a polymer is a direct consequence of the polymerization process. Through the kurtosis, we characterize the early-stage non-Gaussian behavior within a phase diagram, and we also put forward an estimation for the crossover time to ordinary Brownian motion.

## 1. Introduction

Diffusion in crowded and complex systems such as biological cells is usually very heterogeneous, and anomalous behavior—where the mean square displacement of tracers varies non linearly with time—is envisaged [1–3]. Over the last few years a new class of diffusive processes has been reported, where the mean square displacement is found to grow linearly in time like in standard, Brownian diffusion, but with a corresponding probability density function (PDF) which is strongly non-Gaussian [4–16]. This behavior, termed Brownian yet non-Gaussian diffusion [6, 8], occurs quite robustly in a wide range of systems, including beads diffusing on lipid tubes [6] or in networks [6, 7], the motion of tracers in colloidal, polymeric or active suspensions [4, 17–19] and in biological cells [12, 20, 21], as well as the motion of individuals in heterogeneous populations such as nematodes [5]. Similar effects on the PDF are also observed in the anomalous diffusion [22] of labeled messenger RNA molecules in living *E*.*coli* and *S*.*cervisiae* cells. In the majority of cases, at larger time the form of the PDF crosses over to the normal, Gaussian one. Therefore, such change cannot be simply due to the heterogeneity of the tracers, unless some of their properties vary with time. More plausibly, the anomalous-to-Gaussian transition might be induced by temporal fluctuations of the diffusion coefficient, due to rearrangements of properties of tracers or of the surrounding medium. To mimic such behaviors, models in which the diffusion varies with time by obeying a stochastic equation have been introduced and solved both analytically and numerically. These models are referred in the literature as “diffusing diffusivity models” [23–32], and it has been shown that for short times they are intimately related to the idea of superstatistics [33]. In the latter approach, an ensemble of particles is assumed to be characterized by different diffusion coefficients and it is then described as a mixture of Gaussian PDFs, weighted by the distribution of the diffusivities. As a result, the ensemble dynamics is still Brownian, yet the PDF of particle displacements corresponds to a Gaussian mixture and it is thus not Gaussian anymore.

Although diffusing diffusivity models qualitatively reproduce the experimental observations, they work at a mesoscopic scale and without a visible connection to the underlying molecular processes. It is therefore becoming increasingly relevant to find strategies that bridge the gap between the paradigm of diffusing diffusivity and the microscopic realm, in order to fully understand this form of anomalous diffusion. In this paper we show how the diffusion of polymers during a polymerization process offers one possible mechanism to realize this connection^{1}. It is well known from polymer theory [36] that the motion of the center of mass of a linear chain is Brownian, but with a diffusivity constant which is inversely proportional to *N*^{α}, where *N* is the number of monomers and α an exponent ranging from 1/2 (Rouse model) to 2 (reptation model). During an equilibrated polymerization processes the number *N* fluctuates in time and its statistics can be obtained through the exact solution of its stationary master equation. By using a continuous approximation for this temporally homogeneous birth-death Markov process [37], it emerges that in the limit of large systems such process converges to an Ornstein-Uhlenbeck, as it is assumed in most of the diffusing diffusivity models [24]. The time scale of the Ornstein-Uhlenbeck process is linearly proportional to the volume of the system and this guarantees that the non-Gaussian behavior can be accessible experimentally by tuning such parameter.

## 2. Polymerization Process

Polymers are made of relatively simple subunits (monomers) assembled with one another through different mechanisms and geometries. The result is a macromolecule which may contain from a few tens (in the case oligomers), to several thousand monomer units [38], or even millions as in the case of DNA and RNA molecules. From a biological point of view, the polymerization process occurs regularly either within or outside the cell [39]. In particular, cells might trigger polymerization by several mechanisms such as the *de novo* nucleation of new filaments, the uncapping of existing barbed ends (actin) and rescuing a depolymerizing filament (commonly observed for microtubules).

In order to guarantee the existence of equilibrium conditions, here we consider a polymerization process occurring in a closed volume with a fixed total number of monomers *N*_{t}. For sake of simplicity, in what follows we suppose that one filament only can nucleate and that subunits may bind reversibly onto both ends of the chain. At each end, the addition and deletion of monomers can be represented as [40]

where *A*_{N} is the filament with *N* subunits, and *k*_{+}, *k*_{−} are the rate constants for association and dissociation, respectively. Hence,

where *M*(*t*) = *c*(*t*)*V* is the number of monomeric subunits, *c* its concentration and *V* the system volume. The probability of a filament with *n* monomers at time *t* given *n*_{0} units at time *t*_{0}, *P*_{N}(*n, t*|*n*_{0}, *t*_{0}) satisfies the (forward) master equation of a temporally homogeneous birth-death Markov process [37]:

with stepping functions

and *c*(*n*) = (*N*_{t} − *n*)/*V*. Through these choices, we are assuming with certainty the existence in solution of a filament with at least one monomer. The factor 2 in *W*_{+} models a linear polymer which grows at both ends without developing branching; *W*_{−} is instead concerned with the possible bonds which may break down. Equilibrium is reached under detailed balance *W*_{−}(*n*) = *W*_{+}(*n*) (3 ≤ *n* ≤ *N*_{t}), corresponding to a polymer composed by

monomers, and to a number

of single monomers in solution. We remark that the rate constants *k*_{+}, *k*_{−} are specific to the polymerization chemical reactions. Given a certain kind of polymer, the average polymer size and the average number of single monomers in solution are thus controlled by the total number of subunits *N*_{t} and by the volume of the system *V*, which are quantities easily controlled in experiments. In the following analysis, we find it convenient to replace the volume with the fraction 0 < λ < 1 of *N*_{t} that compose the polymer at equilibrium; clearly, *V* = (1 − λ) *N*_{t}*k*_{+}/*k*_{−}.

As we prove in the Appendix, for any given *N*_{t} and independently from *n*_{0}, the stationary solution ${P}_{N}(n)\equiv {lim}_{t\to \infty}{P}_{N}(n,t|{n}_{0},{t}_{0})$ reads

with a normalization factor

Γ(·, ·) being the upper incomplete gamma function [41],

and Γ(·) the Euler gamma function. We may observe that with (1 − λ)*N*_{t} → 0 the two Gamma functions in the normalization factor become equal and simplify to 1; in this limit, probabilities for small *n* are suppressed. Indeed, in section 4 we show that *P*_{N}(*n*) becomes close to a Gaussian for large λ and *N*_{t}. In view of the inverse power-law relation with the diffusion coefficient of the center of mass, it is however the behavior for small *n* which affects the probability of large diffusivities, triggering in turn strong deviations from ordinary diffusion which are described in the following Section.

## 3. Brownian Yet Non-Gaussian Diffusion of the Center of Mass

From polymer physics we know that the center of mass **R**_{G} of a macromolecules with *N* subunits diffuses with a coefficient $D(N)={D}_{0}/{N}^{\alpha}$, *D*_{0} being a diffusion coefficient specific of the considered subunit. This means

with * B*(

*t*) a (three-dimensional) Wiener process (Brownian motion). Reference values for the exponent α are:

• α = 1/2 in the Rouse model [36, 42], where the polymer is composed of *N* equivalent beads with neither excluded-volume nor hydrodynamic interaction;

• α = 1 for the Zimm model [36, 43], where hydrodynamic is taken into account;

• α = 2 for the reptation model which describes tagged polymer motion in entangled polymer solutions [36, 44].

In view of the previous analysis, we understand that polymerization confers a random character to **R**_{G}, providing a clear microscopic origin to the “diffusing diffusivity” process we are going to detail next.

From Equation (7) we readily obtain the stationary distribution for the diffusion coefficient of the polymer's center of mass,

and its first moment

Imagine now to perform a particle-tracking experiment at constant *N*_{t} and *V* and to monitor the position of **R**_{G} in stationary conditions. At a given initial instant the polymer possesses a size *n*, and thus a diffusion coefficient ${D}_{n}={D}_{0}/{n}^{\alpha}$ with probability given by Equation (12). For time smaller than the characteristic decay τ of the autocorrelation of the process *N*(*t*), the experimental PDF amounts then to a Gaussian mixture (also called “superstatistics”) [6, 23, 33] weighted by Equation (12). In addition, its second moment grows linearly with time as in the ordinary Brownian motion. Such a phenomenon of “Brownian yet non Gaussian diffusion” [6, 8] has been recently modeled at a mesoscopic scale in terms of diffusing diffusivity models [23–32]. It is only at time larger than τ that ordinary (Gaussian) Brownian motion is recovered, with a diffusion coefficient *D*_{av}. Before giving an estimate of τ for our model (see next section), we study the early time non-Gaussianity in the full phase diagram [*N*_{t}, λ], together with its dependence on α.

The non-Gaussian behavior distinctive of **R**_{G}(*t*) at time 0 ≤ *t* ≪ τ can be properly characterized by referring to one of its Cartesian coordinates, say *x*. The PDF of the *x*-displacements takes the form

In Figure 1 we plot Equation (13) for α = 1 and different values of λ and *N*_{t}. At first sight, non-Gaussianity increases with decreasing *N*_{t} and λ; below we however show that the behavior is not monotonic. To measure deviations from Gaussianity we consider the kurtosis of *p*_{X}(*x, t*),

(κ = 3 for any Gaussian variable). In our case it is straightforward to see that

independently of *D*_{0}. Notice instead the strong dependence of κ from α; moreover, κ > 3 (positive excess kurtosis or leptokurtic PDF). In order to illustrate regions of more pronounced non-Gaussianity and to discuss their dependence on α in Figure 2 we draw the kurtosis level curves within a (λ, *N*_{t})-phase diagram. Note that, for a given pair (*N*_{t}, λ), higher values of the exponent α give rise to larger kurtosis (compare Figures 2A,B).

**Figure 1**. PDF of the *x*-coordinate of **R**_{G} for 0 ≤ *t* ≪ τ, at fixed *N*_{t} **(A)**, and fixed λ **(B)**. The PDF is rescaled such that the variance is unity; recall that in a log-linear plot Gaussian PDFs have parabolic shape. In both cases, α = 1.

**Figure 2**. Phase diagram of the early-stage non-Gaussianity for **(A)** α = 1 and **(B)** α = 1/2. The thick, violet, line at the right end of both plots corresponds to τ*k*_{−} = 1 (please refer to text for details).

As quoted, by looking at the plots in Figure 1 one may expect the kurtosis to steadily increase by decreasing λ and *N*_{t}. The structure of the phase diagram implies instead the existence of a maximum kurtosis, both at given λ and *N*_{t}. Indeed, for any horizontal or vertical line traced through the phase diagram (Figure 2) it is possible to find a family of kurtosis level curves each intersecting the line in two distinct points. Between each couple of intersection points the kurtosis first raises and then decreases, thus reaching a maximum value. This is highlighted in Figure 3. Albeit within a small portion of the phase space, the maximum kurtosis can be extremely high, as reported in Figure 4; for instance, *k*_{max} ≃ 40 corresponds to an average polymer size of order *N*_{eq} ≃ 350 with ${N}_{\text{t}}\simeq 1{0}^{4}$.

## 4. Crossover to Brownian, Gaussian Diffusion

The stationary distribution in Equation (7) is exact, but it does not provide information about the decay time-scale τ of initial conditions for the process *N*(*t*). To get such an insight, we next workout a continuous approximation for the polymerization process. In the gedankenexperiment reported above, τ is the persistence time scale of the randomly chosen initial diffusion coefficient for **R**_{G}, corresponding in turn to the typical duration of the leptokurtic PDF for the diffusion of the center of mass.

We start by noticing that around equilibrium, for *N*_{t} ≫ 1 and *N*_{eq} ≫ *M*_{eq} (large λ), *N*(*t*) can be approximated as a continuous Markov process with Langevin equation [37]

where *B*(*t*) is a Wiener process (Brownian motion). Taking further advantage of the large *N*_{eq} assumption, we then introduce the rescaled quantity $\stackrel{~}{N}\equiv N/{N}_{\text{eq}}$, obeying

to which we may apply the *weak noise approximation*. Indeed, one may straightforwardly prove [37] that for large *N*_{eq} Equation (18) is satisfied by the approximate solution

with $\stackrel{~}{n}(t)$ a deterministic process satisfying

and *Y*(*t*) the stochastic process defined by the Langevin equation

The solution of the deterministic process,

asymptotically tends to 1 with a characteristic decay time

Correspondingly, the long-time behavior of *Y*(*t*) is that of an Ornstein-Uhlenbeck process:

where ℕ(μ, σ^{2}) is a Gaussian variable with mean μ and variance σ^{2}. Hence, the stationary solution of $\stackrel{~}{N}$ is

For the polymer size $N=\stackrel{~}{N}{N}_{\text{eq}}$, this implies

We thus appreciate that, to be self consistent, the continuous approximation requires large values of *N*_{t} to blur out discreteness, and *N*_{eq} ≫ *M*_{eq} so that the negative support of the Gaussian PDF corresponds to a negligible probability. Figure 5 shows that when *N*_{t} and λ are both large the weak noise approximation of the stationary distribution *P*_{N}(*n*) is almost indistinguishable from the exact solution. On the other hand, decreasing either *N*_{t} or λ the approximation fails concomitantly with the fact that the Gaussian probability of negative *n*-values becomes significant. Depending on the specific cut in phase-space, the approximation may or may not work well in correspondence to the maximum kurtosis (compare red full lines in Figures 5A,B).

**Figure 5**. Stationary PDF of the polymerization process. Comparison between the exact PDF in Equation (7) (symbols) and the continuous, weak noise approximation associated to Equation (25) (curves). Values for the parameters *N*_{t} and λ have been chosen to facilitate comparison with Figure 1. Specifically, continuous red curves correspond to choices in Figure 1. By decreasing either λ at fixed *N*_{t} **(A)** or *N*_{t} at fixed λ **(B)** the weak noise approximation breaks down.

When applicable, the important result conveyed by the continuous, weak noise approximation is that through Equation (22) it establishes the time scale of the decay of the autocorrelation of *N*(*t*). It would be nice to give an explicit representation of τ in terms of the control parameters (λ, *N*_{t}); however, Equation (22) shows that it further depends on the dissociation rate constant *k*_{−}, which is specific to the chosen polymer. To get a qualitative insight, in Figure 2 we have added the line

representing the locus of points for which τ is equal to the inverse of *k*_{−}. Notice that the largest kurtosis level curve lay at the left of the line, a region which is also characterized by τ > 1/*k*_{−}. Hence, the farther left of the line the longer lasts the Brownian yet non-Gaussian diffusion stage.

## 5. Conclusions

We have been able to analytically characterize the stochastic motion of the center of mass of a fluctuating filament undergoing a simple polymerization process. Depending on experimentally accessible parameters such as the the total monomers in the solution *N*_{t} and the system volume *V* (equivalently, the fraction λ of total monomers composing the filament in equilibrium), the center of mass displays at early times a Brownian, yet non-Gaussian, diffusion. To our knowledge, this is one of the first example in which this anomalous behavior is directly linked to a microscopic prototype: the effect originates from the fluctuations of *N* (due to polymerization) and from the relation $D(N)={D}_{0}/{N}^{\alpha}$ which distinguishes many microscopic models of polymeric diffusion. By studying the kurtosis of the early-time displacement PDF along the *x*-coordinate we quantified deviations from Gaussian behavior in the phase diagram (λ, *N*_{t}), highlighting the dependence on the exponent α. Remarkably, the kurtosis is not monotonic and displays a maximum at either λ or *N*_{t} fixed. Finally, on the basis of a continuum (weak noise) approximation for the stochastic process *N*(*t*), we put forward an estimation for the time τ(λ, *N*_{t}) at which the anomalous behavior crosses over to ordinary Brownian motion. Since the weak noise approximation is not applicable in the whole (λ, *N*_{t}) phase diagram, and also in view of the non-monotonic behavior of the kurtosis, further studies approaching the determination of τ are welcome.

In parallel with the analytical results, we proposed a *gedankenexperiment* in which the anomalous behavior could be detected. As a further perspective, we may notice that if we shift the focus on the diffusion of a tagged monomer (in place of the center of mass of the polymer), in the early stage of the process a *subdiffusive* behavior coupled to non-Gaussianity is expected to be observed, with a crossover to a Brownian regime at the Rouse time [36]. This analysis is intended to be the subject of future work.

In conclusion, we believe that this work provides a valuable analytical backdrop to Brownian yet non-Gaussian diffusion, a fascinating phenomenon reported to occur in many physical systems. To fully understand this anomalous behavior, it is essential to ground it on a microscopic spring. This is the case for the presented model, but we are confident than others more will come along these lines.

## Data Availability

The datasets generated for this study are available on request to the corresponding author.

## Author Contributions

All authors listed have made a substantial, direct and intellectual contribution to the work, and approved it for publication.

## Funding

FB and FS acknowledge financial support from a 2019 PRD project of the Physics and Astronomy Department of the University of Padova, Italy (BIRD 191017).

## Conflict of Interest Statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

## Acknowledgments

The authors would like to thank M. Baiesi, G. Falasco, and A.L. Stella for useful discussions.

## Supplementary Material

The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fphy.2019.00124/full#supplementary-material

## Footnotes

1. ^Along different lines, connections between polymerization processes and anomalous diffusion have been pointed out in Oshanin and Moreau [34] and Sposini et al. [35].

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Keywords: polymer dynamics, polymerization process, anomalous diffusion, non-Gaussian, crossover to Gaussian

Citation: Baldovin F, Orlandini E and Seno F (2019) Polymerization Induces Non-Gaussian Diffusion. *Front. Phys.* 7:124. doi: 10.3389/fphy.2019.00124

Received: 05 July 2019; Accepted: 15 August 2019;

Published: 24 September 2019.

Edited by:

Carlos Mejía-Monasterio, Polytechnic University of Madrid, SpainReviewed by:

Gleb Oshanin, Sorbonne Universités, FranceHaroldo Valentin Ribeiro, State University of Maringá, Brazil

Aljaz Godec, Max Planck Institute for Biophysical Chemistry, Germany

Copyright © 2019 Baldovin, Orlandini and Seno. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Fulvio Baldovin, baldovin@pd.infn.it

^{†}These authors have contributed equally to this work