Frontiers in Cell and Developmental Biology

Review

Published on 03 Sep 2025

Organoids in biliary research: insights into developmental signaling and applications in disease modeling

in Signaling

Boming Peng
Min Huang
Jianquan Zhang
Yang Xiang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1656019

4,014 views

Original Research

Published on 26 Aug 2025

Slit2 inhibits SRC-PI3K signaling pathway, regulates osteoclast differentiation of macrophages and reduces bone resorption

in Signaling

Qing Ge
Yaokun Zou
Huizhi Deng
Zhe Yang
Linhu Ge
Jieying Huang
Jianqiang Cai
Liping Wang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1632882

2,468 views

Review

Published on 26 Aug 2025

Critical signaling pathways in osteoclast differentiation and bone resorption: mechanisms and therapeutic implications for periprosthetic osteolysis

in Signaling

Liangzi Yin
Chenglin Sun
Junjie Zhang
Yan Li
Yansheng Wang
Lunhao Bai
Zeming Lei

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1639430

5,411 views
5 citations

Review

Published on 22 Aug 2025

The multifaceted roles of E3 ubiquitin ligases in osteoarthritis

in Signaling

Zheng Jin
Zhenhua Zhu
Jun Chen
Xiaopeng Jing
Jie Tan
Ji Zeng

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1665313

1,720 views

Original Research

Published on 20 Aug 2025

Endogenous ligands of bovine FFAR2/GPR43 display distinct pharmacological properties

in Signaling

Tainara Cristina Michelotti
Valérie Lamothe
Frédéric Jean-Alphonse
Eric Reiter
Muriel Bonnet
Guillaume Durand

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1645031

2,019 views

Review

Published on 15 Aug 2025

The role of gut microbiota dysbiosis in drug-induced brain injury: mechanisms and therapeutic implications

in Signaling

Jinghui Zhai
Yue Zhang
Shuyue Ma
Yingli Zhang
Miao Jin
Huiyu Yan
Sixi Zhang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1604539

2,402 views
1 citation

Opinion

Published on 15 Aug 2025

RAC1 signaling in prostate cancer: VAV GEFs take center stage

in Signaling

Mariana Cooke
Nahuel Peinetti
Marcelo G. Kazanietz
Kerry L. Burnstein

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1658639

1,911 views
1 citation

Editorial

Published on 12 Aug 2025

Editorial: Deciphering signaling pathway interactions in tissue homeostasis

in Signaling

John T. Hancock

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1677790

1,071 views

Original Research

Published on 12 Aug 2025

The lncRNA Jpx participates in testosterone-induced H9c2 cell hypertrophy by targeting the miR-145-5p/Nfatc3 axis

in Signaling

Mingxing Wen
Xinyu Zhang
Litao Tong
Yuhui Chen
Zhengjie Li
Yichen Wang
Can Liu
Jinwei Zhang
Liangpeng Ge
Jing Sun

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1620369

1,599 views

Correction

Published on 08 Aug 2025

Correction: KRAS and NRF2 drive metabolic reprogramming in pancreatic cancer cells: the influence of oxidative and nitrosative stress

in Signaling

Valentina Rapozzi
Clara Comuzzi
Eros Di Giorgio
Luigi E. Xodo

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1661525

1,055 views

Review

Published on 08 Aug 2025

The multifaceted impact of physical exercise on FoxO signaling pathways

in Signaling

Wei Liu
Pengjun Meng
Zhi Li
Yifei Shen
Xin Meng
Shen Jin
Mengdi Hu

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1614732

5,283 views
5 citations

Original Research

Published on 07 Aug 2025

Protective effects of paederoside in rotenone-induced cellular models of Parkinson’s disease

in Signaling

Juan Lang
Zhongkui Xiong

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1631652

1,961 views

Original Research

Published on 05 Aug 2025

Epigenetic regulation of the respiratory chain by a mitochondrial distress-related redox signal

in Signaling

Marius W. Baeken
Ankush Borlepawar
Philipp Kötzner
Holger Richly
Christian Behl
Bernd Moosmann
Parvana Hajieva

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1608400

3,678 views
2 citations

Original Research

Published on 24 Jul 2025

TRABD maintains mitochondrial homeostasis and protects against ischemia reperfusion-induced renal tubular injury

in Signaling

Wenqi Duan
Wenye Wu
Cui Yang
Mei Zhang
Xuemei Li
Wenmin Tian
Yang Chen
Xinjun Zhang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1619339

2,136 views
1 citation

Editorial

Published on 18 Jul 2025

Editorial: Neuronal guidance signaling in health and neurological diseases

in Signaling

Satoru Yamagishi
Masaki Hiramoto
Junichi Yuasa-Kawada

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1661836

1,463 views

Brief Research Report

Published on 16 Jul 2025

The β-adrenergic receptor-SGK1 signaling pathway in brown adipocytes protects GOT1 from proteasomal degradation

in Signaling

Chul-Hong Park
Minsung Park
J. Jason Collier
Ji Suk Chang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1637770

2,383 views

Review

Published on 10 Jul 2025

Mechanosensitive Piezo channels in mineralized tissues: emerging roles in osteodental adaptation and disease

in Signaling

Junchi Dong
Ran Li
Yuhuang Chen
Guixin Zhu
Xing Liang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1607337

4,823 views

Editorial

Published on 09 Jul 2025

Editorial: Functions and regulation of p90RSK and its family: mechanisms, roles in diseases, and implications in therapeutics

in Signaling

Ling Lin
Nhat-Tu Le
Kebin Hu

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1648101

1,116 views

Review

Published on 09 Jul 2025

The pathogenesis and therapeutic strategies of heat stroke-induced endothelial injury

in Signaling

Shaokang Wang
Xiaoting Zhang
Yongqi Zhang
Nannan Wu
Lulong Bo
Meitang Wang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1569346

4,634 views
3 citations

Review

Published on 04 Jul 2025

Involvement of role of HMGB1-NLRP3 pathway in systemic disorders

in Signaling

Lei Yang
Xue Li
Xiaoming Zhu
Futao Ge
Yuantao Wang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1600596

3,215 views
2 citations

Review

Published on 02 Jul 2025

Hippo/YAP signaling’s multifaceted crosstalk in cancer

in Signaling

Jie Zhang
Haipeng Wu
Xinxin Ren
Zhuoshi Chen
Siyu Ye
Shuchang Chen
Jie Fang
Qirou Wu
Tiejun Zhao

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1595362

6,054 views
5 citations

Review

Published on 30 Jun 2025

Neuronal guidance behaviours: the primary cilium perspective

in Signaling

Melody Atkins
Coralie Fassier
Xavier Nicol

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1612555

2,438 views

Review

Published on 27 Jun 2025

Research progress of ECT2 and RhoA-related signaling pathways in gynecological tumors

in Signaling

Liying Sheng
Meili Liang
Yueli Wang
Zhimei Zhou
Yajing Xie
Yumin Ke
Zhuna Wu

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1602649

2,509 views

Review

Published on 27 Jun 2025

Mechanism and regulation of mitophagy in liver diseases: a review

in Signaling

Sen Liu
Libo Wang
Liuyang Zhu
Tianyu Zhao
Pinsheng Han
Fengying Yan
Xiaoliang Wang
Chunli Li
Ze Wang
Bao-feng Yang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1614940

4,138 views
5 citations

1,291 articles

articles

Organoids in biliary research: insights into developmental signaling and applications in disease modeling

Slit2 inhibits SRC-PI3K signaling pathway, regulates osteoclast differentiation of macrophages and reduces bone resorption

Critical signaling pathways in osteoclast differentiation and bone resorption: mechanisms and therapeutic implications for periprosthetic osteolysis

The multifaceted roles of E3 ubiquitin ligases in osteoarthritis

Endogenous ligands of bovine FFAR2/GPR43 display distinct pharmacological properties

The role of gut microbiota dysbiosis in drug-induced brain injury: mechanisms and therapeutic implications

RAC1 signaling in prostate cancer: VAV GEFs take center stage

Editorial: Deciphering signaling pathway interactions in tissue homeostasis

The lncRNA Jpx participates in testosterone-induced H9c2 cell hypertrophy by targeting the miR-145-5p/Nfatc3 axis

Correction: KRAS and NRF2 drive metabolic reprogramming in pancreatic cancer cells: the influence of oxidative and nitrosative stress

The multifaceted impact of physical exercise on FoxO signaling pathways

Protective effects of paederoside in rotenone-induced cellular models of Parkinson’s disease

Epigenetic regulation of the respiratory chain by a mitochondrial distress-related redox signal

TRABD maintains mitochondrial homeostasis and protects against ischemia reperfusion-induced renal tubular injury

Editorial: Neuronal guidance signaling in health and neurological diseases

The β-adrenergic receptor-SGK1 signaling pathway in brown adipocytes protects GOT1 from proteasomal degradation

Mechanosensitive Piezo channels in mineralized tissues: emerging roles in osteodental adaptation and disease

Editorial: Functions and regulation of p90RSK and its family: mechanisms, roles in diseases, and implications in therapeutics

The pathogenesis and therapeutic strategies of heat stroke-induced endothelial injury

Involvement of role of HMGB1-NLRP3 pathway in systemic disorders

Hippo/YAP signaling’s multifaceted crosstalk in cancer

Neuronal guidance behaviours: the primary cilium perspective

Research progress of ECT2 and RhoA-related signaling pathways in gynecological tumors

Mechanism and regulation of mitophagy in liver diseases: a review