Frontiers in Chemistry | Medicinal and Pharmaceutical Chemistry

Original Research

Published on 13 May 2025

Chronic alcohol intake disrupts cytochrome P450 enzyme activity in alcoholic fatty liver disease: insights into metabolic alterations and therapeutic targets

in Medicinal and Pharmaceutical Chemistry

Qian Zhu
Xuefeng Xie
Ling Fang
Cheng Huang
Jun Li

Frontiers in Chemistry

doi 10.3389/fchem.2025.1509785

977 views

Original Research

Published on 12 May 2025

Identification of novel potential hypoxia-inducible factor-1α inhibitors through machine learning and computational simulations

in Medicinal and Pharmaceutical Chemistry

Yuxiang He
Shuning Diao
Shengzhen Hou
Taiying Li
Wenhui Meng
Jinping Zhang

Frontiers in Chemistry

doi 10.3389/fchem.2025.1585882

1,049 views

Original Research

Published on 12 May 2025

Development of nifedipine isosteres: an integrated approach to the design, synthesis, and biological assessment of calcium channel blockers

in Medicinal and Pharmaceutical Chemistry

Yasser M. Zohny
Samir M. Awad
Omar Alsaidan
Maha A. Rabie

Frontiers in Chemistry

doi 10.3389/fchem.2025.1581037

1,151 views

Original Research

Published on 08 May 2025

Discovery of a novel binding pocket in PPARγ for partial agonists: structure-based virtual screening identifies ginsenoside Rg5 as a partial agonist promoting beige adipogenesis

in Medicinal and Pharmaceutical Chemistry

Zhen Wang
Kexin Shui
Zehui Zhang
Yihan Chen
Nanfei Yang
Shiliang Ji
Pingping Shen
Qiang Tian

Frontiers in Chemistry

doi 10.3389/fchem.2025.1579445

2,051 views

Original Research

Published on 08 May 2025

Mechanism of hedysari radix praeparata cum melle and curcumae rhizoma herb pair in colitis-associated colorectal cancer through the MAPK/NF-κB signaling pathway: an investigation in vivo and in vitro

in Medicinal and Pharmaceutical Chemistry

Ting Liu
Yugui Zhang
Feiyun Gao
Zhuanhong Zhang
Maomao Wang
Cui Ma
Yanjun Wang
Dingcai Ma
Zhe Wang
Xingke Yan

Frontiers in Chemistry

doi 10.3389/fchem.2025.1551722

1,252 views

Original Research

Published on 06 May 2025

Design, synthesis, and biological investigation of new thiazole-based derivatives as multi-targeted inhibitors endowed with antiproliferative, antioxidant, and antibacterial properties

in Medicinal and Pharmaceutical Chemistry

Hesham A. M. Gomaa
Asmaa M. Atta
Mohamed E. Shaker
Sami I. Alzarea
Tariq G. Alsahli
Eid Alatwi
Arafa Musa
Fatma A. M. Mohamed
Hayat Ali Alzahrani
Aliaa M. Mohassab

Frontiers in Chemistry

doi 10.3389/fchem.2025.1595997

3,257 views

Original Research

Published on 29 Apr 2025

Proposal of a new chemical marker for the quality control of the herb Scleromitrion diffusum

in Medicinal and Pharmaceutical Chemistry

Tao Zheng
Chu-Chu Zhong
Grace Gar-Lee Yue
Dong-Min Jiang
Man-Ho Tong
Hiu-Yan Wong
Kwan-Ho Wong
Meng-Hua Wu
David Tai-Wai Lau
Hui Cao

Frontiers in Chemistry

doi 10.3389/fchem.2025.1600769

1,028 views

Review

Published on 29 Apr 2025

Modification of biopharmaceutical parameters of flavonoids: a review

in Medicinal and Pharmaceutical Chemistry

Amir Taldaev
Artem A. Svotin
Semyon I. Obukhov
Roman P. Terekhov
Irina A. Selivanova

Frontiers in Chemistry

doi 10.3389/fchem.2025.1602967

1,285 views

Original Research

Published on 25 Apr 2025

Chemical profile of Rhododendron luteum Sweet leaf supercritical CO2 extracts and their anti-inflammatory and antidiabetic potential

in Medicinal and Pharmaceutical Chemistry

Lena Łyko
Renata Nowak
Marta Olech
Urszula Gawlik
Agnieszka Krajewska
Danuta Kalemba
Andriy Prokopiv

Frontiers in Chemistry

doi 10.3389/fchem.2025.1576852

1,138 views

Mini Review

Published on 25 Apr 2025

The quinoline framework and related scaffolds in natural products with anti-Leishmania properties

in Medicinal and Pharmaceutical Chemistry

Gloria Yaluff
Leídi Herrera
Miriam Soledad Rolón
Celeste Vega
Hugo Cerecetto

Frontiers in Chemistry

doi 10.3389/fchem.2025.1571067

1,716 views
2 citations

Original Research

Published on 25 Apr 2025

Effect of freeze-pressure regulated extraction technology on the physicochemical properties and pharmacological activities of guizhi extract

in Medicinal and Pharmaceutical Chemistry

Huiling Zhang
Juanzhen Luo
Qinzhao Wan
Xuecheng Wang
Zhenfeng Wu
Ming Yang
Yaqi Wang

Frontiers in Chemistry

doi 10.3389/fchem.2025.1581429

855 views

Original Research

Published on 22 Apr 2025

Toxicity mechanism analysis of cGAS-STING-TBK1 signaling pathway small molecule modulator based on network toxicology and molecular docking strategy: quinacrine acetate as an example

in Medicinal and Pharmaceutical Chemistry

Jinchao Zhu
Qingyuan Lin
Honglin Zhu
Siqi Xie
Shengdong Nie

Frontiers in Chemistry

doi 10.3389/fchem.2025.1584588

1,918 views

Review

Published on 16 Apr 2025

Research progress on extraction, separation, structure, and biological activities of polysaccharides from jujube fruit (Ziziphus jujuba Mill.): a review

in Medicinal and Pharmaceutical Chemistry

Feilong Jia
Bo Wang
Hui Ma
Changcai Bai
Yuanyuan Zhang

Frontiers in Chemistry

doi 10.3389/fchem.2025.1581947

1,213 views

Original Research

Published on 16 Apr 2025

Design, synthesis, in silico studies, and apoptotic antiproliferative activity of novel thiazole-2-acetamide derivatives as tubulin polymerization inhibitors

in Medicinal and Pharmaceutical Chemistry

Lamya H. Al-Wahaibi
Ali M. Elshamsy
Taha F. S. Ali
Bahaa G. M. Youssif
Stefan Bräse
Mohamed Abdel-Aziz
Nawal A. El-Koussi

Frontiers in Chemistry

doi 10.3389/fchem.2025.1565699

8,449 views

Original Research

Published on 16 Apr 2025

Computational identification of potential natural terpenoid inhibitors of MDM2 for breast cancer therapy: molecular docking, molecular dynamics simulation, and ADMET analysis

in Medicinal and Pharmaceutical Chemistry

Eva Azme
Md. Mahmudul Hasan
Md. Liakot Ali
Rashedul Alam
Neamul Hoque
Fabiha Noushin
Mohammed Fazlul Kabir
Ashraful Islam
Tanzina Sharmin Nipun
S. M. Moazzem Hossen

Frontiers in Chemistry

doi 10.3389/fchem.2025.1527008

2,277 views
1 citation

Original Research

Published on 10 Apr 2025

Antioxidant activity and selective cytotoxicity in HCT-116 and WI-38 cell lines of LC-MS/MS profiled extract from Capparis spinosa L

in Medicinal and Pharmaceutical Chemistry

Amjad Ibrahim Oraibi
Ashour H. Dawood
Ghada Trabelsi
Ousman B. Mahamat
Leila Chekir-Ghedira
Soumaya Kilani-Jaziri

Frontiers in Chemistry

doi 10.3389/fchem.2025.1540174

1,302 views
1 citation