Frontiers in Immunology

Original Research

Published on 05 Dec 2025

An integrated immunoinformatic approach to design a novel multiepitope chimeric vaccine against Mycoplasma phocimorsus as a causal agent of bloodstream infections

in Vaccines and Molecular Therapeutics

Rongrong Yu
Ahmad Hasan
Muhammad Ibrahim
Wadi B. Alonazi
Li Bin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1719398

553 views

Original Research

Published on 05 Dec 2025

Integration of single-cell and bulk RNA-seq via machine learning to reveal ferroptosis- and lipid metabolism-driven immune landscape heterogeneity and predict immunotherapy response in colon cancer

in Cancer Immunity and Immunotherapy

Weifeng Wang
Xuanhao Lin
Chufa Zheng
Peixiu Yao
Dejin Xie
Yiyan Lin
Xiaozhong Wang
Weiqin Hong

Frontiers in Immunology

doi 10.3389/fimmu.2025.1699079

1,026 views

Original Research

Published on 05 Dec 2025

Stratified shared genetic architecture of IBD and RA: an integrated analysis from polygenic overlap to directional heterogeneity

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Yiwen Jia
Yuntian Xia
Siyuan Chen
Guangming Feng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1711302

347 views

Mini Review

Published on 05 Dec 2025

Next-generation vaccines against bacterial pathogens: mRNA and beyond

in Vaccines and Molecular Therapeutics

Huimin Chen
Ye Gu
Lei Song
Lihui Si

Frontiers in Immunology

doi 10.3389/fimmu.2025.1709794

865 views

Case Report

Published on 05 Dec 2025

Massive lower gastrointestinal bleeding due to rupture of the superior mesenteric artery branch in Behçet’s disease: case report

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Jing-fen Ye
Jian-long Guan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1668761

488 views

Review

Accepted on 04 Dec 2025

PANoptosis in Urological Diseases: Molecular Mechanisms, Pathological Roles, and Emerging Therapeutic Opportunities

in Cancer Immunity and Immunotherapy

Xin Di
Xin Jin
Shuqiang Feng
Ranwei Li

Frontiers in Immunology

145 views

Original Research

Accepted on 04 Dec 2025

Research on key indicators for diagnosis and prediction of rheumatoid arthritis based on GBDT+LR embedded feature selection model

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Jiaqi Chen
Qiang Zhang
Zhenqiang Huang
Chunsheng Qu

Frontiers in Immunology

105 views

Case Report

Accepted on 04 Dec 2025

Telitacicept for systemic lupus erythematosus-associated peripheral neuropathy: A case report

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

JinHui Tan

Frontiers in Immunology

249 views

Mini Review

Accepted on 04 Dec 2025

Molecular Mechanisms of Streptococcal Disruption of the Blood-Brain Barrier and Their Pathogenic Role in Bacterial Meningitis

in Inflammation

Yumei Shi
Tao Liang
Chao Shi
Benhai Yao
Bo Xiong
JUN ZHANG

Frontiers in Immunology

120 views

Original Research

Accepted on 04 Dec 2025

Xuanqing Hefa formula relieves sepsis-triggered acute lung injury by targeting the NLRP3/Caspase-1 pyroptosis mechanism

in Immunological Tolerance and Regulation

Can Lei
Chunxia Zhao
Xucheng Li
Kangli Wang
Tianfen Cen
Qingquan Liu
Xiaolong Xu
Jun Zhang

Frontiers in Immunology

158 views

Original Research

Accepted on 04 Dec 2025

Disproportionality analysis of drug-associated Progressive Multifocal Leukoencephalopathy: Roles of underlying diseases and immunomodulatory therapies in FAERS

in Multiple Sclerosis and Neuroimmunology

Xiaozhen Lin
Naishen Qin
Baoxiao He
Jinhua Chen
Weiling Liu

Frontiers in Immunology

207 views

Review

Accepted on 04 Dec 2025

The Application of Genetic Testing Technology in Kidney Transplantation: Precision Matching, Non-Invasive Monitoring and Personalised Management

in Alloimmunity and Transplantation

Ya Long Zhang
Hao Wang
Rui Yan
Kangyu Wang
Jiangwei Man
Li Yang

Frontiers in Immunology

122 views

Original Research

Accepted on 04 Dec 2025

Melanoma causes phenotypic modulations and metabolic switches of iNKT cells influencing clinical outcome

in Molecular Innate Immunity

Emmanuelle Degeorges
Stéphane Mouret
Pauline Girard
Camille Niveau
Mélanie Cettour-Cave
Eleonora Sosa Cuevas
Florence De Fraipont
Julie Charles
Philippe Saas
CAROLINE ASPORD

Frontiers in Immunology

136 views

Original Research

Accepted on 04 Dec 2025

Traumatic brain injury and post-injury sleep fragmentation differentially alter the microglial transcriptome

in Inflammation

Morgan A Taylor
Rebecca Boland
Samuel Houle
Zoe Tapp
Amara Davis
Christopher Cotter
John Sheridan
Jonathan Godbout
Olga N Kokiko-Cochran

Frontiers in Immunology

143 views

Original Research

Published on 04 Dec 2025

Tumor-penetrating peptide boosts bispecific T-cell engager antitumor efficacy for the pancreatic cancer

in Cancer Immunity and Immunotherapy

Lu Zou
Jingjing Chen
Xinyuan Bai
Yingxin Wang
Changchang Lu
Qiaoli Wang
Subiyinuer Tuerhong
Mengzhu Li
Qinghua Zheng
Fanyan Meng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1693755

723 views

Original Research

Published on 04 Dec 2025

Advancing breast cancer biomarkers: a centromere-related gene signature integrated with single-cell analysis for prognostic prediction

in Cancer Immunity and Immunotherapy

Ye Lu
Shengbin Pei
Wenxiang Zhang
Zheng Qu
Xiangyu Wang
Siqing Liu
Hao Dong
Kan Yonemori
Yi Fang
Xiangyi Kong

Frontiers in Immunology

doi 10.3389/fimmu.2025.1678603

396 views

Original Research

Published on 04 Dec 2025

Identification of a ubiquitin-binding domain protein, CD2AP, in predicting the prognosis and treatment of lung adenocarcinoma

in Cancer Immunity and Immunotherapy

Qinjin Dai
Li Li
Mingfeng He
Jin Huang
Zhixiang Bo
Jishan Yin
Ying Ye

Frontiers in Immunology

doi 10.3389/fimmu.2025.1726531

692 views

Review

Published on 04 Dec 2025

Research progress on pyroptosis regulated by mesenchymal stem cell-derived exosomes

in Inflammation

Tingyu Yang
Jiapan An
Xinqi Xu
Bin Li
Zhimin Dou

Frontiers in Immunology

doi 10.3389/fimmu.2025.1717465

788 views

Review

Published on 04 Dec 2025

Epigenetic modifications in vascular inflammation

in Molecular Innate Immunity

Linyi Tang
Liyun Li
Yang Liu
Xin Zhang
Xinglin Wang
Zaiyong Zheng
Ping Yang
Haoran Wu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1711579

514 views

Original Research

Published on 04 Dec 2025

Neutrophil-mediated immune dysregulation in recurrent miscarriage: implications of APP–CD74 signaling and CXCL1 as diagnostic biomarkers

in Inflammation

Shan He
Fei Ma
Meng Yu
Jia-man Wu
You-ming Gong
Ke-wang Luo
Hong Chang
Qi Liang
Yan Ning

Frontiers in Immunology

doi 10.3389/fimmu.2025.1707497

948 views

Review

Published on 04 Dec 2025

Unlocking the mystery of the PD-1/PD-L1 axis: beyond the checkpoint hype

in Cancer Immunity and Immunotherapy

Pierre-Hubert Desimpel
Pierre-Florent Petit
Benoit J Van den Eynde
Jingjing Zhu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1708873

920 views

Original Research

Published on 04 Dec 2025

Differences in the peripheral blood immune landscape between early-onset and late-onset colorectal cancer

in Cancer Immunity and Immunotherapy

Clara Sánchez-Menéndez
Jaime Rodríguez-Pérez
Daniel Fuertes
Valentina Leguizamon
María González-Sanmartín
Elena Mateos
Miguel Cervero
Esther San José
Gonzalo Sanz
Edurne Álvaro

Frontiers in Immunology

doi 10.3389/fimmu.2025.1692382

1,028 views

Mini Review

Published on 04 Dec 2025

Immunosenescence and inflammaging: Mechanisms and modulation through diet and lifestyle

in Inflammation

Ludmila Müller
Svetlana Di Benedetto

Frontiers in Immunology

doi 10.3389/fimmu.2025.1708280

742 views

Brief Research Report

Published on 04 Dec 2025

A data-driven model of macrophage polarization states reveals an IFN macrophage signature in active Crohn’s disease

in Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders

Sarina C. Lowe
Madelaine Leitman
Noah Yan
Alexander Hoffmann

Frontiers in Immunology

doi 10.3389/fimmu.2025.1707719

594 views

48,439 articles

articles

An integrated immunoinformatic approach to design a novel multiepitope chimeric vaccine against Mycoplasma phocimorsus as a causal agent of bloodstream infections

Integration of single-cell and bulk RNA-seq via machine learning to reveal ferroptosis- and lipid metabolism-driven immune landscape heterogeneity and predict immunotherapy response in colon cancer

Stratified shared genetic architecture of IBD and RA: an integrated analysis from polygenic overlap to directional heterogeneity

Next-generation vaccines against bacterial pathogens: mRNA and beyond

Massive lower gastrointestinal bleeding due to rupture of the superior mesenteric artery branch in Behçet’s disease: case report

PANoptosis in Urological Diseases: Molecular Mechanisms, Pathological Roles, and Emerging Therapeutic Opportunities

Research on key indicators for diagnosis and prediction of rheumatoid arthritis based on GBDT+LR embedded feature selection model

Telitacicept for systemic lupus erythematosus-associated peripheral neuropathy: A case report

Molecular Mechanisms of Streptococcal Disruption of the Blood-Brain Barrier and Their Pathogenic Role in Bacterial Meningitis

Xuanqing Hefa formula relieves sepsis-triggered acute lung injury by targeting the NLRP3/Caspase-1 pyroptosis mechanism

Disproportionality analysis of drug-associated Progressive Multifocal Leukoencephalopathy: Roles of underlying diseases and immunomodulatory therapies in FAERS

The Application of Genetic Testing Technology in Kidney Transplantation: Precision Matching, Non-Invasive Monitoring and Personalised Management

Melanoma causes phenotypic modulations and metabolic switches of iNKT cells influencing clinical outcome

Traumatic brain injury and post-injury sleep fragmentation differentially alter the microglial transcriptome

Tumor-penetrating peptide boosts bispecific T-cell engager antitumor efficacy for the pancreatic cancer

Advancing breast cancer biomarkers: a centromere-related gene signature integrated with single-cell analysis for prognostic prediction

Identification of a ubiquitin-binding domain protein, CD2AP, in predicting the prognosis and treatment of lung adenocarcinoma

Research progress on pyroptosis regulated by mesenchymal stem cell-derived exosomes

Epigenetic modifications in vascular inflammation

Neutrophil-mediated immune dysregulation in recurrent miscarriage: implications of APP–CD74 signaling and CXCL1 as diagnostic biomarkers

Unlocking the mystery of the PD-1/PD-L1 axis: beyond the checkpoint hype

Differences in the peripheral blood immune landscape between early-onset and late-onset colorectal cancer

Immunosenescence and inflammaging: Mechanisms and modulation through diet and lifestyle

A data-driven model of macrophage polarization states reveals an IFN macrophage signature in active Crohn’s disease