Frontiers in Immunology | B Cell Biology

Brief Research Report

Published on 06 Nov 2025

Biochemical analysis reveals aberrant and variable Immunoglobulin M composition in Waldenström macroglobulinemia and IgM monoclonal gammopathy of unknown significance

in B Cell Biology

Nienke Oskam
Wouter Verhaar
Pleuni Ooijevaar-de Heer
Karima Amaador
Ninotska I. L. Derksen
Sofie Keijzer
Marie José Kersten
Marij Streutker
Josephine M. I. Vos
Theo Rispens

Frontiers in Immunology

doi 10.3389/fimmu.2025.1670408

1,933 views

Original Research

Published on 05 Nov 2025

The tropomyosin 3.1/3.2 inhibitor ATM-3507 alters B-cell actin dynamics and impairs the growth and motility of diffuse large B-cell lymphoma cell lines

in B Cell Biology

Abhishek Bedi
Kate Choi
Alyssa Iskierski
Michael R. Gold

Frontiers in Immunology

doi 10.3389/fimmu.2025.1668379

1,923 views

Original Research

Published on 31 Oct 2025

B cell receptor repertoire reconstitution in patients with neuromyelitis optica spectrum disorder receiving B-cell depletion therapy

in B Cell Biology

Hyo Jae Kim
Wangyong Shin
Dayoung Seo
Inhye Jang
Jihong Ryu
Lynkyung Choi
Jinhee Kim
Hyunjin Kim
Young-Min Lim
Eun-Jae Lee

Frontiers in Immunology

doi 10.3389/fimmu.2025.1673508

2,670 views

Mini Review

Published on 30 Oct 2025

The dual immunomodulatory role of B cells in tumorigenesis: mechanisms, microenvironment crosstalk, and therapeutic implications

in B Cell Biology

Zhuangwei Lv
Ruohao Yang
Kai Zhang
Ruihan Wang
Xiaoyu Shi
Jinhua Wu
LuLu Liu
Junna Jiao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1649812

3,484 views
1 citation

Original Research

Published on 20 Oct 2025

CD39 is an antibody-secreting B-cell marker that modulates germinal center and antibody responses during infection

in B Cell Biology

Laura Almada
Yamila N. Gazzoni
Cristian G. Beccaria
Facundo Fiocca Vernengo
Santiago Boccardo
Melisa Gorosito Serrán
Apurwa Trivedi
Carola G. Vinuesa
Simon C. Robson
Eva V. Acosta Rodríguez

Frontiers in Immunology

doi 10.3389/fimmu.2025.1547929

3,209 views

Original Research

Published on 17 Oct 2025

Pediatric B cell repertoires are enriched for naive clonal phenotypes and are shaped by distinct selection dynamics

in B Cell Biology

Thomas Hsiao
Areen Shtewe
Uri Hershberg

Frontiers in Immunology

doi 10.3389/fimmu.2025.1618234

2,594 views

Original Research

Published on 16 Oct 2025

B cell subpopulations and their role in the pathogenesis of primary Sjögren’s syndrome: insights from single-cell RNA sequencing

in B Cell Biology

Xiaoyu Zhang
Yuanwei Han
Jing Zhang
Yu Song
Yan Zhou
Jia Wang
Jinhai Tian
Xinran Xin
Bin Liu
Li Fang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1665086

4,164 views
1 citation

Original Research

Published on 15 Oct 2025

Impacts of tacrolimus and glucocorticoids on peripheral blood T and B lymphocyte subsets in myasthenia gravis

in B Cell Biology

Xuan Wu
Wei Chen
Huanhuan Song
Guorong Xu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1667799

3,145 views

Original Research

Published on 14 Oct 2025

Agglutinin chip screening of B cell surface biomarkers in Hashimoto’s thyroiditis for therapeutic targeting

in B Cell Biology

Jun-ling Ren
Xiao-ming Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1636003

2,971 views

Original Research

Published on 13 Oct 2025

Directed evolution of drug-like Aβ conformation-specific antibodies

in B Cell Biology

Alec A. Desai
Matthew D. Smith
Jennifer M. Zupancic
Emily K. Makowski
Yulei Zhang
Julia E. Gerson
Shannon J. Moore
Alexandra B. Sutter
Sean P. Ferris
Magdalena I. Ivanova

Frontiers in Immunology

doi 10.3389/fimmu.2025.1655893

3,126 views

Original Research

Published on 08 Oct 2025

Bexarotene signaling in human B and T lymphocytes induces gut-homing receptor expression

in B Cell Biology

Sina Kaiser
Ina Suhrkamp
Jinru He
Charlotte Helf
Christian D. Sadik
Michael Weichenthal
Guido Heine

Frontiers in Immunology

doi 10.3389/fimmu.2025.1664199

2,884 views

Review

Published on 02 Oct 2025

Immunoglobulin: unraveling its complex web in aging

in B Cell Biology

Qiaoli Gu
Yi Wang
Can Zhu
Xichao Zhou
Li Ni
Huan Zhao
Huilin Yang
Qin Shi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1690018

5,039 views

Mini Review

Published on 29 Sep 2025

Developmental trajectory of long-lived plasma cells

in B Cell Biology

Takuya Koike
Wataru Ise

Frontiers in Immunology

doi 10.3389/fimmu.2025.1684210

5,595 views

Mini Review

Published on 25 Sep 2025

The half-century odyssey of regulatory B cells: from Breg discovery to emerging frontiers

in B Cell Biology

Elina A. Zheremyan
Nikolai R. Kon
Alina S. Ustiugova
Ekaterina M. Stasevich
Elvina A. Bogomolova
Matvey M. Murashko
Aksinya N. Uvarova
Denis E. Demin
Dmitry V. Kuprash
Kirill V. Korneev

Frontiers in Immunology

doi 10.3389/fimmu.2025.1681082

4,367 views
1 citation

Original Research

Published on 22 Sep 2025

Toll-like receptor 7/8 agonist stimulation rapidly skews the antibody repertoire of B cells in non-human primates

in B Cell Biology

Shiyu Wang
Michael Citron
Lihua Luo
I-Ming Wang
Xiao Liu
Wei Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1647209

3,427 views
1 citation

Original Research

Published on 10 Sep 2025

YBX1 modulates humoral immunity through post-transcriptional regulation in B cells

in B Cell Biology

Viktoria Kunz
Kathryn S. Bommert
Ralf Bargou
Kurt Bommert

Frontiers in Immunology

doi 10.3389/fimmu.2025.1653073

3,031 views
1 citation

Original Research

Published on 08 Sep 2025

FCRLs and atypical transcriptional pattern in tumor infiltrating B cells from lung and renal cancer

in B Cell Biology

Ekaterina A. Bryushkova
Evgenii V. Shchoka
Daniil K. Lukyanov
Marina B. Gikalo
Natalya Mushenkova
Konstantin K. Laktionov
Alexey M. Kazakov
Oybek A. Khalmurzaev
Vsevolod B. Matveev
Dmitriy M. Chudakov

Frontiers in Immunology

doi 10.3389/fimmu.2025.1587088

3,734 views

Original Research

Published on 08 Sep 2025

RUNX1 expression dynamics in plasma cell differentiation and pathogenesis of multiple myeloma

in B Cell Biology

Ting Fang Tang
Yee Teng Chan
Hui Jing Lim
Yi Ying Cheok
Nur Adila Anuar
Chin Sum Cheong
Chung Yeng Looi
Sen Mui Tan
Won Fen Wong
Gin Gin Gan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1643615

2,394 views
1 citation

Original Research

Published on 04 Sep 2025

Tenascin-C regulates CXCR4+ B cell migration and cortex formation in the developing bursa of Fabricius

in B Cell Biology

Ádám Soós
Emőke Szőcs
Viktória Halasy
Csenge Jurenka
Nándor Nagy

Frontiers in Immunology

doi 10.3389/fimmu.2025.1636140

2,194 views

Original Research

Published on 02 Sep 2025

Maturation of human early-minted blood antibody-secreting cells is coupled with increased IgG secretion rates

in B Cell Biology

Doan C. Nguyen
Ian T. Hentenaar
Monica Cabrera-Mora
Shuya Kyu
Andrea Morrison-Porter
Natalie S. Haddad
Joel Andrews
Danielle Roberts
Sagar Lonial
Ignacio Sanz

Frontiers in Immunology

doi 10.3389/fimmu.2025.1644102

15,976 views
2 citations

Editorial

Published on 28 Aug 2025

Editorial: B-cell deficiency and infection: exploring humoral immunity’s protective mechanisms

in B Cell Biology

Alexandros Grammatikos
Peter Bergman

Frontiers in Immunology

doi 10.3389/fimmu.2025.1678416

2,652 views

Original Research

Published on 25 Aug 2025

Engrafted NSG-SGM3 humanized mice spontaneously produce human immunoglobulins including IgE

in B Cell Biology

Erica V. Lin
Rebecca A. Krier-Burris
Kristina A. Sokol
Betania Arce
Natalia M. Vilela
Robert G. Hamilton
Bruce S. Bochner
Melanie C. Dispenza

Frontiers in Immunology

doi 10.3389/fimmu.2025.1628194

4,306 views

Original Research

Published on 21 Aug 2025

Conventional and non-conventional antigen-binding sites promote the development and function of chronic lymphocytic leukemia stereotyped subset #4 clones

in B Cell Biology

Yun Liu
Dzmitry Padhorny
Rosa Catera
Antonella Nicolo
Xiao-Jie Yan
Stan Xiaogang Li
Anastasia Iatrou
Andrea N. Mazzarello
Noemi Destefani
Steven L. Allen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1607189

2,827 views

Case Report

Published on 21 Aug 2025

Obinutuzumab-induced severe acute thrombocytopenia: a case report and literature review

in B Cell Biology

Kun Kou
Qiaolin Zhou
Lijun Du
Fang Xu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1609862

2,929 views
2 citations

1,037 articles

articles

Biochemical analysis reveals aberrant and variable Immunoglobulin M composition in Waldenström macroglobulinemia and IgM monoclonal gammopathy of unknown significance

The tropomyosin 3.1/3.2 inhibitor ATM-3507 alters B-cell actin dynamics and impairs the growth and motility of diffuse large B-cell lymphoma cell lines

B cell receptor repertoire reconstitution in patients with neuromyelitis optica spectrum disorder receiving B-cell depletion therapy

The dual immunomodulatory role of B cells in tumorigenesis: mechanisms, microenvironment crosstalk, and therapeutic implications

CD39 is an antibody-secreting B-cell marker that modulates germinal center and antibody responses during infection

Pediatric B cell repertoires are enriched for naive clonal phenotypes and are shaped by distinct selection dynamics

B cell subpopulations and their role in the pathogenesis of primary Sjögren’s syndrome: insights from single-cell RNA sequencing

Impacts of tacrolimus and glucocorticoids on peripheral blood T and B lymphocyte subsets in myasthenia gravis

Agglutinin chip screening of B cell surface biomarkers in Hashimoto’s thyroiditis for therapeutic targeting

Directed evolution of drug-like Aβ conformation-specific antibodies

Bexarotene signaling in human B and T lymphocytes induces gut-homing receptor expression

Immunoglobulin: unraveling its complex web in aging

Developmental trajectory of long-lived plasma cells

The half-century odyssey of regulatory B cells: from Breg discovery to emerging frontiers

Toll-like receptor 7/8 agonist stimulation rapidly skews the antibody repertoire of B cells in non-human primates

YBX1 modulates humoral immunity through post-transcriptional regulation in B cells

FCRLs and atypical transcriptional pattern in tumor infiltrating B cells from lung and renal cancer

RUNX1 expression dynamics in plasma cell differentiation and pathogenesis of multiple myeloma

Tenascin-C regulates CXCR4+ B cell migration and cortex formation in the developing bursa of Fabricius

Maturation of human early-minted blood antibody-secreting cells is coupled with increased IgG secretion rates

Editorial: B-cell deficiency and infection: exploring humoral immunity’s protective mechanisms

Engrafted NSG-SGM3 humanized mice spontaneously produce human immunoglobulins including IgE

Conventional and non-conventional antigen-binding sites promote the development and function of chronic lymphocytic leukemia stereotyped subset #4 clones

Obinutuzumab-induced severe acute thrombocytopenia: a case report and literature review