Frontiers in Immunology | Molecular Innate Immunity

Review

Published on 27 Nov 2025

Neutrophils as key drivers of pulmonary fibrosis: unveiling mechanisms and therapeutic implications

in Molecular Innate Immunity

Xiuping Liang
Yanhong Li
Ziyi Tang
Yubin Luo
Yi Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1718092

2,739 views
1 citation

Original Research

Published on 26 Nov 2025

C3 mutations and poor pegcetacoplan response in paroxysmal nocturnal hemoglobinuria

in Molecular Innate Immunity

Santiago Rodríguez de Córdoba
Andrea Reparaz Suevos
Silvia González Sanz
Francisco J. Fernández
M. Cristina Vega
Enrique Colado Varela
Alejandro Lada Colunga
Juan Carlos Vallejo Llamas
Ana Pilar Gonzalez-Rodríguez

Frontiers in Immunology

doi 10.3389/fimmu.2025.1723596

1,831 views
1 citation

Mini Review

Published on 26 Nov 2025

Inflammation-driven mechanisms in endometrial cancer: pathways from inflammatory microenvironment remodeling to immune escape

in Molecular Innate Immunity

Zhaoping Tan
Binyue Sheng
Lu Chen
Hong Dong
Yaqin Deng
Yunyun Li
Cong Liu
Han Wang
Zi Yang
Ting Xie

Frontiers in Immunology

doi 10.3389/fimmu.2025.1689114

2,030 views
1 citation

Editorial

Published on 25 Nov 2025

Editorial: Role of endogenous regulators of innate immunity in sepsis

in Molecular Innate Immunity

Haichao Wang
Xianzhong Meng
Daolin Tang
Yongming Yao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1745170

1,168 views

Review

Published on 25 Nov 2025

Neutrophil extracellular traps in rheumatoid arthritis: pathogenic mechanisms and therapeutic potential

in Molecular Innate Immunity

Cheng-Liang Mao
Chen-Huan Yu
Song-Lin Jiang
Zhen-Hua Ying
Xing-Yi Zhu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1717671

3,246 views

Original Research

Published on 24 Nov 2025

Circulating innate lymphoid cells and IL-18 as potential immune biomarkers in thymic tumors

in Molecular Innate Immunity

Daniela Claudia Maresca
Maria Rosaria Saponaro
Evelina La Civita
Marianna Tortora
Benedetta Romano
Erica Pietroluongo
Fabio Somma
Mario Giuliano
Alberto Servetto
Giovannella Palmieri

Frontiers in Immunology

doi 10.3389/fimmu.2025.1705648

1,472 views

Original Research

Published on 21 Nov 2025

Phosphorylation-driven effector switching of Rab7 and Rab12 by the leucine-rich repeat kinase 1 in mast cells

in Molecular Innate Immunity

Jana Omar-Kabha
Sewar Omari
Yaara Gorzalczany
Fatima Amer-Sarsour
Elisabeth Kleeblatt
Mitsunori Fukuda
Avraham Ashkenazi
Ronit Sagi-Eisenberg

Frontiers in Immunology

doi 10.3389/fimmu.2025.1709196

1,255 views

General Commentary

Published on 20 Nov 2025

Commentary: Complement genetic variants and FH desialylation in S. pneumoniae-haemolytic uraemic syndrome

in Molecular Innate Immunity

Laura M. Baas
Nicole C. A. J. van de Kar
Marloes A. H. M. Michels
Lambertus P. van den Heuvel

Frontiers in Immunology

doi 10.3389/fimmu.2025.1707529

857 views

Original Research

Published on 19 Nov 2025

Manganese mediates antiviral effects by driving an ATM -TBK1 phosphorylation signaling pathway

in Molecular Innate Immunity

Hongyan Sui
Rosana Wiscovitch-Russo
Silvia Cachaco
Jun Yang
Whitney Bruchey
Sylvain Laverdure
Qian Chen
Tomozumi Imamichi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1708516

1,463 views

Original Research

Published on 19 Nov 2025

Plasma lipidomic signatures reveal age-associated patterns of septic shock risk and immune dysregulation in sepsis

in Molecular Innate Immunity

Yuhan Sun
Ke Lin
Ling Wang
Jingwen Ai
Jingjing Zhao
Ruiwen Sun
Xiaoyang Cheng
Yanmin Wan
Peng Cui
Sen Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1659425

1,951 views

Original Research

Published on 19 Nov 2025

Significant alterations in peripheral lymphocyte subsets and immune-related protein profiles in patients with periprosthetic joint infection

in Molecular Innate Immunity

Zhuo Li
Fan Yang
Jun Fu
Zhi-Yuan Li
Li-Bo Hao
Lin Yuan
Ji-Ying Chen
Chi Xu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1648150

957 views

Original Research

Published on 18 Nov 2025

RIG-I drives protective type I interferon production by glial cells in response to Neisseria meningitidis and Streptococcus pneumoniae challenge

in Molecular Innate Immunity

Krishna J. Majithia
M. Brittany Johnson

Frontiers in Immunology

doi 10.3389/fimmu.2025.1692421

1,634 views

Original Research

Published on 17 Nov 2025

Comprehensive analysis of metabolism-related genes in sepsis reveals metabolic–immune heterogeneity and highlights GYG1 as a potential therapeutic target

in Molecular Innate Immunity

Jie Zheng
Kangjie Qin
Xiaoqin Wang
Banghai Feng
Yuting Zhang
Yiyu Wang
Han Qin
Qiuyu Dai
Xinxin Liu
Kun Yu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1682846

1,966 views

Original Research

Published on 17 Nov 2025

Unraveling the gut microbiota–SCFAs–cathepsin C pathway in preeclampsia: a novel therapeutic target

in Molecular Innate Immunity

Fan Lu
Houkang Lei
Xiang Xiao
Luzhu Yu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1700781

2,145 views

Original Research

Published on 14 Nov 2025

Extracellular microRNAs modulate human microglial function through TLR8

in Molecular Innate Immunity

Hannah Weidling
Edyta Motta
Leonard D. Kuhrt
Christina Krüger
Caio Andreeta Figueiredo
Thomas Wallach
Silke Frahm
Sebastian Diecke
Susanne A. Wolf
Helmut Kettenmann

Frontiers in Immunology

doi 10.3389/fimmu.2025.1645062

2,659 views
1 citation

Review

Published on 13 Nov 2025

Circular RNAs and their emerging roles in muscular immune-related diseases

in Molecular Innate Immunity

Felicita Urzi
Anja Srpčič
Katja Lakota

Frontiers in Immunology

doi 10.3389/fimmu.2025.1675567

2,081 views

Original Research

Published on 13 Nov 2025

Cold temperature enhances innate eosinophilic airway inflammation via transient receptor potential ankyrin1

in Molecular Innate Immunity

Yoichi Dotake
Takahiro Matsuyama
Kentaro Machida
Hiromi Matsuyama
Koichi Takagi
Keiko Mizuno
Keiko Kan-o
Tomoyuki Kuwaki
Hiromasa Inoue
Kentaro Tanaka

Frontiers in Immunology

doi 10.3389/fimmu.2025.1655919

2,270 views

Editorial

Published on 10 Nov 2025

Editorial: Oral immunology – interplay of molecules, cells and oral tissue environment

in Molecular Innate Immunity

James Deschner
Kerstin Galler
Jonathan Jantsch

Frontiers in Immunology

doi 10.3389/fimmu.2025.1729801

788 views

Original Research

Published on 04 Nov 2025

Deciphering oligomeric proanthocyanidins’ dual osteoprotective mechanisms at single-cell resolution: NR4A1-mediated PTGS2 suppression and β-catenin-Runx2 activation

in Molecular Innate Immunity

Li Huang
Yuwei Sun
Yi Zheng
Shicheng Qiu
Jianping Zheng
Chunhan Sun
Mingwei Chen
Shaowei Zheng
Yirong Zeng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1679987

2,190 views

Mini Review

Published on 04 Nov 2025

From chronic inflammation to immune escape: mapping the tumor microenvironment evolution in renal cell carcinoma

in Molecular Innate Immunity

Hanjun Xu
Baojun Tu
Hui Li
Yong Shan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1683844

2,183 views

Mini Review

Published on 03 Nov 2025

Immune snapshots along the inflammation-to-cancer road in bladder urothelium

in Molecular Innate Immunity

Lingxiang Lu
Fei Wang
Zhenfan Wang
Shuai Guo
Minjun Jiang
Zheng Ma

Frontiers in Immunology

doi 10.3389/fimmu.2025.1685237

1,838 views
1 citation

Review

Published on 03 Nov 2025

Regulation of the innate immune response in rheumatoid arthritis

in Molecular Innate Immunity

Aikeremujiang Muheremu
Shalayiding Aierxiding
Jian Gao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1545625

2,643 views

Mini Review

Published on 31 Oct 2025

The complement pathway and the pathophysiology of fibroproliferative cutaneous scarring

in Molecular Innate Immunity

Ilja L. Kruglikov
Katarzyna Walendzik
Philipp E. Scherer

Frontiers in Immunology

doi 10.3389/fimmu.2025.1701998

1,665 views
1 citation

Original Research

Published on 31 Oct 2025

Global research hotspots and trends in microglia in ischemic stroke

in Molecular Innate Immunity

Yingquan Liu
Yu Ye
Fan Dai
Lin Bai
Hongjie Ji
Xingxing Su
Peijia Hu
Hongliang Cheng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1622499

2,320 views

3,596 articles

articles

Neutrophils as key drivers of pulmonary fibrosis: unveiling mechanisms and therapeutic implications

C3 mutations and poor pegcetacoplan response in paroxysmal nocturnal hemoglobinuria

Inflammation-driven mechanisms in endometrial cancer: pathways from inflammatory microenvironment remodeling to immune escape

Editorial: Role of endogenous regulators of innate immunity in sepsis

Neutrophil extracellular traps in rheumatoid arthritis: pathogenic mechanisms and therapeutic potential

Circulating innate lymphoid cells and IL-18 as potential immune biomarkers in thymic tumors

Phosphorylation-driven effector switching of Rab7 and Rab12 by the leucine-rich repeat kinase 1 in mast cells

Commentary: Complement genetic variants and FH desialylation in S. pneumoniae-haemolytic uraemic syndrome

Manganese mediates antiviral effects by driving an ATM -TBK1 phosphorylation signaling pathway

Plasma lipidomic signatures reveal age-associated patterns of septic shock risk and immune dysregulation in sepsis

Significant alterations in peripheral lymphocyte subsets and immune-related protein profiles in patients with periprosthetic joint infection

RIG-I drives protective type I interferon production by glial cells in response to Neisseria meningitidis and Streptococcus pneumoniae challenge

Comprehensive analysis of metabolism-related genes in sepsis reveals metabolic–immune heterogeneity and highlights GYG1 as a potential therapeutic target

Unraveling the gut microbiota–SCFAs–cathepsin C pathway in preeclampsia: a novel therapeutic target

Extracellular microRNAs modulate human microglial function through TLR8

Circular RNAs and their emerging roles in muscular immune-related diseases

Cold temperature enhances innate eosinophilic airway inflammation via transient receptor potential ankyrin1

Editorial: Oral immunology – interplay of molecules, cells and oral tissue environment

Deciphering oligomeric proanthocyanidins’ dual osteoprotective mechanisms at single-cell resolution: NR4A1-mediated PTGS2 suppression and β-catenin-Runx2 activation

From chronic inflammation to immune escape: mapping the tumor microenvironment evolution in renal cell carcinoma

Immune snapshots along the inflammation-to-cancer road in bladder urothelium

Regulation of the innate immune response in rheumatoid arthritis

The complement pathway and the pathophysiology of fibroproliferative cutaneous scarring

Global research hotspots and trends in microglia in ischemic stroke