ORIGINAL RESEARCH article
Front. Mater.
Sec. Biomaterials and Bio-Inspired Materials
Comparative Analysis of the Impact of Modern Cavity Disinfectants on Dentin Bond Strength
Provisionally accepted
- 1Batman University, Batman, Türkiye
- 2Cukurova Universitesi, Adana, Türkiye
- 3Kahramanmaras Sutcu Imam Universitesi, Kahramanmaras, Türkiye
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
The durability of the hybrid layer, essential for successful bonding, depends on collagen stability. Dentin MMPs degrade collagen over time, reducing bond strength; thus, MMP inhibitors help maintain durability. This study evaluates the short-term (24 h) and long-term (12 months) effects of dentin pretreatment agents—CHX, QC, NR, RF, and α-TF—on bond strength. A total of 144 extracted human molars were randomly divided into six groups and treated for 60 seconds before application of All-Bond Universal and composite resin. A nanohybrid flowable composite was placed using a starch tube to obtain 1-mm² bonded specimens. Half of the samples (n = 12) were tested after 24 hours; the others underwent thermocycling to simulate 12 months of aging prior to μSBS testing with a universal testing machine (MOD Dental MIC-101, Esetron Smart Robotechnologies, Ankara, Turkey) at 0.5 mm/min. Failure modes were examined under a stereomicroscope. Data were analyzed using one-way ANOVA and Tukey post hoc tests (p < .05). After 24 hours, QC exhibited the highest μSBS, followed by CHX and NR, all significantly higher than α-TF. After 12 months, QC, RF, and NR showed increased μSBS, while Con, CHX, and α-TF decreased. QC and NR appear effective natural alternatives to CHX, with QC showing the most promising long-term results.
Keywords: Cavity disinfectants, Chlorhexidine, Dentin pretreatment, Flavonoid, Micro shear bond strength (μSBS), Naringin, Quercetin
Received: 03 Oct 2025; Accepted: 09 Dec 2025.
Copyright: © 2025 Gümüş, sonkaya and keçeci. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Simge Gümüş
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.