Frontiers in Oncology | Pharmacology of Anti-Cancer Drugs

Original Research

Published on 02 Jan 2026

HPV-driven transcriptome and splicing rewiring under SRPK1 inhibition in cervical cancer

in Pharmacology of Anti-Cancer Drugs

Afra Basera
Mohammed Alaouna
Janie Duvenhage
David O. Bates
Zodwa Dlamini
Rahaba Marima

Frontiers in Oncology

doi 10.3389/fonc.2025.1712170

338 views

Original Research

Accepted on 26 Dec 2025

Inhibition of colorectal cancer progression through conformation-specific targeting of ADAM10 metalloprotease

in Pharmacology of Anti-Cancer Drugs

Pargol Mashati
Dan Sun
Eduardo Garcia Reino
Giuseppe Militello
Nicholas Gao
Jessica A. Blandino
Nayanendu Saha
Dimitar B. Nikolov
Prem K Premsrirut

Frontiers in Oncology

126 views

Case Report

Published on 18 Dec 2025

Donafenib intolerance in hepatocellular carcinoma: severe hand–foot skin reaction and successful switch to lenvatinib – a case report and literature review

in Pharmacology of Anti-Cancer Drugs

Ying Chen
Linglin Fu
Ping Song
Yinuo Tan
Yuqi Jin

Frontiers in Oncology

doi 10.3389/fonc.2025.1728098

612 views

Case Report

Accepted on 17 Dec 2025

Antimicrobial photodynamic therapy for severe acute radiodermatitis in patients undergoing head and neck radiotherapy: a case series and literature review

in Pharmacology of Anti-Cancer Drugs

Isabella Macedo Costa Silva
Carolina de Souza Custódio
Mylene Martins Monteiro
Karina Alexandra Batista da Silva Freitas
Talita Oliveira Lima
Wenzel Castro Abreu
Ricardo Gomes Reis
Eliete Neves Silva Guerra
Elaine Barros Ferreira
Paula Elaine Diniz Dos Reis

Frontiers in Oncology

117 views

Original Research

Accepted on 17 Dec 2025

Nab-Paclitaxel versus Paclitaxel for Taxane Acute Pain Syndrome (TAPS) in Solid Tumors: A Systematic Review and Meta-Analysis

in Pharmacology of Anti-Cancer Drugs

Lai Wei
Hongbo Li
ZhiYong Wang

Frontiers in Oncology

129 views

Original Research

Published on 15 Dec 2025

The effect of dosing sequence of programmed death receptor-1 inhibitors combined with chemotherapy on adverse effects in the real world

in Pharmacology of Anti-Cancer Drugs

HaoChun Tang
Ziyuan Zhou
Yuelin Zhang
Jun Pan
Jun Meng

Frontiers in Oncology

doi 10.3389/fonc.2025.1645091

521 views

Original Research

Published on 08 Dec 2025

Human fibrosarcoma cells selected for ultra-high doxorubicin resistance, acquire trabectedin cross-resistance, remain sensitive to recombinant methioninase, and have increased c-MYC expression

in Pharmacology of Anti-Cancer Drugs

Sei Morinaga
Qinghong Han
Kohei Mizuta
Byung Mo Kang
Michael Bouvet
Norio Yamamoto
Katsuhiro Hayashi
Hiroaki Kimura
Shinji Miwa
Kentaro Igarashi

Frontiers in Oncology

doi 10.3389/fonc.2025.1704021

560 views

Case Report

Published on 08 Dec 2025

Case Report: Successful management of high-volume paclitaxel extravasation with hyaluronidase and dry warm compresses

in Pharmacology of Anti-Cancer Drugs

Boris Dudík
Maroš Kunderlík
Bela Mriňáková
Zuzana Lukáčová
Vanda Ušáková
Ján Klimas

Frontiers in Oncology

doi 10.3389/fonc.2025.1699608

726 views

Original Research

Published on 08 Dec 2025

A novel approach to enhance beta-sitosterol bioavailability isolated from Jurinea macrocephala (a high-altitude) plant in biodegradable chitosan against lung cancer

in Pharmacology of Anti-Cancer Drugs

Monica Sangral
Ankita Singh
Ashutosh Gupta
Madhulika Bhagat

Frontiers in Oncology

doi 10.3389/fonc.2025.1659465

698 views

Review

Published on 04 Dec 2025

Artificial intelligence in oncology drug development and management: a precision medicine perspective

in Pharmacology of Anti-Cancer Drugs

Caixia Fang
Pengfa Zhou
Xuerong Zhang
Yongsheng He
Qingwei Yang

Frontiers in Oncology

doi 10.3389/fonc.2025.1609827

1,958 views

Review

Published on 02 Dec 2025

Overcoming resistance in advanced urothelial carcinoma: mechanisms of escape from antibody-drug conjugates and FGFR3 inhibition

in Pharmacology of Anti-Cancer Drugs

Brandon Wummer
Michael Schwartz
Jordan Ciuro
Shahid Ahmed
Shreyas S. Joshi
Vikram M. Narayan
Bradley C. Carthon
Mehmet Asim Bilen
Jacqueline T. Brown

Frontiers in Oncology

doi 10.3389/fonc.2025.1654771

1,189 views

Original Research

Published on 01 Dec 2025

Antitumor efficacy of 5-aminolevulinic acid (5-ALA)-based radiodynamic therapy under single-dose X-ray irradiation in colon cancer

in Pharmacology of Anti-Cancer Drugs

Junko Takahashi
Shinsuke Nagasawa
Xiupeng Wang

Frontiers in Oncology

doi 10.3389/fonc.2025.1722919

854 views

Original Research

Published on 01 Dec 2025

The value of 18F-FDG PET/CT imaging in predicting the efficacy of PD-1/PD-L1 immune checkpoint inhibitors in advanced non-small cell lung cancer

in Pharmacology of Anti-Cancer Drugs

Huiwen Luo
Linlin Li
Jian Wang
Xuefeng Hou
Xiaofeng Li
Wengui Xu
Wen Zhou
Dong Dai

Frontiers in Oncology

doi 10.3389/fonc.2025.1651843

1,228 views

Case Report

Published on 26 Nov 2025

Case Report: Nirogacestat therapy induces rapid response in a patient with refractory, life-threatening desmoid tumor

in Pharmacology of Anti-Cancer Drugs

Dennis Christoph Harrer
Markus Herrmann
Martin Vogelhuber
Sebastian Geis
Daniel Mahr
Maya Niethard
Felix Keil
Gerardo Napodano
Wolfgang Herr
Matthias Grube

Frontiers in Oncology

doi 10.3389/fonc.2025.1714475

783 views

Review

Published on 24 Nov 2025

PARP inhibitors as radiosensitizers: a comprehensive review of preclinical evidence and clinical applications

in Pharmacology of Anti-Cancer Drugs

Xiaodong Luo
Shuo Gao
Kaiyang Sun
Zhiqiang Dong
Shude Yang

Frontiers in Oncology

doi 10.3389/fonc.2025.1702121

1,234 views

Correction

Published on 17 Nov 2025

Correction: Lathyrol inhibits the proliferation of Renca cells by altering expression of TGF-β/Smad pathway components and subsequently affecting the cell cycle

in Pharmacology of Anti-Cancer Drugs

Shengyou Song
Yalin Song

Frontiers in Oncology

doi 10.3389/fonc.2025.1725790

355 views

Review

Published on 06 Nov 2025

Consensus on managing delayed methotrexate elimination in high-dose therapy: insights from the Middle East

in Pharmacology of Anti-Cancer Drugs

Mubarak Al Manasour
Ahmad Absi
Ahmad Alhuraiji
Muhammad Faisal Khanani
Kayane Mheidly
Mohamed Elsaid
Walid Ballourah
Murtadha Al-Khabori
Naser Al Zain
Nisreen Khalifa

Frontiers in Oncology

doi 10.3389/fonc.2025.1660937

1,681 views

Brief Research Report

Published on 05 Nov 2025

Serial TIL infusions and PD-1 blockade drive long-term clonal persistence in prostate cancer

in Pharmacology of Anti-Cancer Drugs

Lucas C. M. Arruda
Julia Karbach
Dragan Kiselicki
Kathrin Brand
Claudia Wahle
Evgueni Sinelnikov
Dirk Gustavus
Hans Hoffmeister
Akin Atmaca
Elke Jäger

Frontiers in Oncology

doi 10.3389/fonc.2025.1693912

1,674 views

Original Research

Published on 05 Nov 2025

Artificial intelligence-based evaluation of prognostic benefits from immunotherapy plus targeted therapy with or without radiotherapy or TACE in advanced hepatocellular carcinoma

in Pharmacology of Anti-Cancer Drugs

Yuehong Deng
Shiqin Song
Huarong Zhao
Yuqian Yang
Simin Lu
Xueting Li

Frontiers in Oncology

doi 10.3389/fonc.2025.1694565

1,153 views

Original Research

Published on 03 Nov 2025

Mechanism of active component β-sitosterol from Myristica fragrans inducing apoptosis in bladder cancer cells via regulating the BCL-2/BAX/caspase-3 pathway

in Pharmacology of Anti-Cancer Drugs

Yongkang Zhu
Zhao Tang
Zhaoyue Lu
Dongyang Gao
Hao Pan
Haozhe Jiang
Zhen Zhang
Huiqing Zhang

Frontiers in Oncology

doi 10.3389/fonc.2025.1698721

914 views

Original Research

Published on 29 Oct 2025

Experimental study on the treatment of norepinephrine transporter-overexpressing pheochromocytomas and paragangliomas: a synthetic lethality strategy combining 131I-MIBG with PARP inhibitors

in Pharmacology of Anti-Cancer Drugs

Jieping Song
Lulu Zhang
Fan Qiu
Xiumin Shi
Rui Tian
Chuan Zhang
Xiaoyuan Li
Feng Wang

Frontiers in Oncology

doi 10.3389/fonc.2025.1681054

709 views

Review

Published on 21 Oct 2025

Overcoming cancer drug resistance: insights into Apoptotic pathway modulation by plant-based nanoparticle and natural products

in Pharmacology of Anti-Cancer Drugs

Amit Kumar Singh
Prem Prakash Kushwaha
Ajaya Kumar Singh
Abhay K. Pandey

Frontiers in Oncology

doi 10.3389/fonc.2025.1677380

2,212 views

Systematic Review

Published on 15 Oct 2025

Evaluating the efficacy and safety of tebentafusp in the treatment of metastatic uveal melanoma: a 2025 update systematic review and meta-analysis

in Pharmacology of Anti-Cancer Drugs

Yanlin Wang
Wen Sun
Bing Wang

Frontiers in Oncology

doi 10.3389/fonc.2025.1667282

3,036 views

Review

Published on 13 Oct 2025

The role of cytostatic in oxidative stress reactions

in Pharmacology of Anti-Cancer Drugs

Renata Polaniak
Aleksander Kwiatkowski
Michał Górski
Elżbieta Grochowska-Niedworok
Małgorzata Latocha

Frontiers in Oncology

doi 10.3389/fonc.2025.1667522

1,396 views

1,123 articles

articles

HPV-driven transcriptome and splicing rewiring under SRPK1 inhibition in cervical cancer

Inhibition of colorectal cancer progression through conformation-specific targeting of ADAM10 metalloprotease

Donafenib intolerance in hepatocellular carcinoma: severe hand–foot skin reaction and successful switch to lenvatinib – a case report and literature review

Antimicrobial photodynamic therapy for severe acute radiodermatitis in patients undergoing head and neck radiotherapy: a case series and literature review

Nab-Paclitaxel versus Paclitaxel for Taxane Acute Pain Syndrome (TAPS) in Solid Tumors: A Systematic Review and Meta-Analysis

The effect of dosing sequence of programmed death receptor-1 inhibitors combined with chemotherapy on adverse effects in the real world

Human fibrosarcoma cells selected for ultra-high doxorubicin resistance, acquire trabectedin cross-resistance, remain sensitive to recombinant methioninase, and have increased c-MYC expression

Case Report: Successful management of high-volume paclitaxel extravasation with hyaluronidase and dry warm compresses

A novel approach to enhance beta-sitosterol bioavailability isolated from Jurinea macrocephala (a high-altitude) plant in biodegradable chitosan against lung cancer

Artificial intelligence in oncology drug development and management: a precision medicine perspective

Overcoming resistance in advanced urothelial carcinoma: mechanisms of escape from antibody-drug conjugates and FGFR3 inhibition

Antitumor efficacy of 5-aminolevulinic acid (5-ALA)-based radiodynamic therapy under single-dose X-ray irradiation in colon cancer

The value of 18F-FDG PET/CT imaging in predicting the efficacy of PD-1/PD-L1 immune checkpoint inhibitors in advanced non-small cell lung cancer

Case Report: Nirogacestat therapy induces rapid response in a patient with refractory, life-threatening desmoid tumor

PARP inhibitors as radiosensitizers: a comprehensive review of preclinical evidence and clinical applications

Correction: Lathyrol inhibits the proliferation of Renca cells by altering expression of TGF-β/Smad pathway components and subsequently affecting the cell cycle

Consensus on managing delayed methotrexate elimination in high-dose therapy: insights from the Middle East

Serial TIL infusions and PD-1 blockade drive long-term clonal persistence in prostate cancer

Artificial intelligence-based evaluation of prognostic benefits from immunotherapy plus targeted therapy with or without radiotherapy or TACE in advanced hepatocellular carcinoma

Mechanism of active component β-sitosterol from Myristica fragrans inducing apoptosis in bladder cancer cells via regulating the BCL-2/BAX/caspase-3 pathway

Experimental study on the treatment of norepinephrine transporter-overexpressing pheochromocytomas and paragangliomas: a synthetic lethality strategy combining 131I-MIBG with PARP inhibitors

Overcoming cancer drug resistance: insights into Apoptotic pathway modulation by plant-based nanoparticle and natural products

Evaluating the efficacy and safety of tebentafusp in the treatment of metastatic uveal melanoma: a 2025 update systematic review and meta-analysis

The role of cytostatic in oxidative stress reactions