Frontiers in Pharmacology | Gastrointestinal and Hepatic Pharmacology

Original Research

Published on 02 Jun 2025

Effects of semaglutide on metabolism and gut microbiota in high-fat diet-induced obese mice

in Gastrointestinal and Hepatic Pharmacology

Luyan Sun
Bingqing Shang
Suyuan Lv
Guolong Liu
Qiu Wu
Yue Geng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1562896

2,321 views

Study Protocol

Published on 30 May 2025

Efficacy and safety of local glucocorticoids for the treatment of acute radiation-induced intestinal injury: protocol of a multicenter randomized controlled trial

in Gastrointestinal and Hepatic Pharmacology

Qianqian Li
Xiaofeng Liu
Lichun Shao
Xiaohua Bao
Cheng Bai
Junchen Ge
Dongshuai Su
Wenda Xu
Ran Jiang
Zhenbin Mu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1529977

1,077 views

Systematic Review

Published on 30 May 2025

A systematic review and meta-analysis of efruxifermin’s efficacy in improving liver fibrosis in patients with NASH/MASH

in Gastrointestinal and Hepatic Pharmacology

Shuzhai Li
Wangyuan Zou
Yingying Zhou
Wenjie Li
Wei Liao
Tao Li
Zhiming Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1594091

2,244 views

Brief Research Report

Published on 30 May 2025

Translational studies on pancreatic cancer and gastric cancer: a methodology in PhD thesis

in Gastrointestinal and Hepatic Pharmacology

Mathilde Resell
Gunnar Qvigstad
Timothy C. Wang
Anne S. Quante
África González-Fernández
Helge Waldum
Duan Chen
Chun-Mei Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1604017

1,071 views

Systematic Review

Published on 27 May 2025

Novel insights from meta-analysis: the efficacy of ginsenosides in non-alcoholic fatty liver disease

in Gastrointestinal and Hepatic Pharmacology

Liyuan Hao
Qing Peng
Shenghao Li
Xiaoyu Hu
Huimin Yan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1564852

1,619 views

Systematic Review

Published on 27 May 2025

Efficacy of interventions with live combined Bacillus subtilis and Enterococcus faecium enteric-coated capsules in metabolic associated fatty liver disease patients: a meta-analysis of randomized controlled trials

in Gastrointestinal and Hepatic Pharmacology

Yutong Wu
Hao Wu
Hang Yi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1610426

1,384 views

Review

Published on 23 May 2025

A potential herbal component for the future treatment of fatty liver disease: Geniposide from gardenia

in Gastrointestinal and Hepatic Pharmacology

Qinyao Zhang
Ziyan Li
Lina Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1610676

1,606 views

Review

Published on 22 May 2025

Pharmacological potential of endocannabinoid and endocannabinoid-like compounds in protecting intestinal structure and metabolism under high-fat conditions

in Gastrointestinal and Hepatic Pharmacology

Francesco Vari
Ilaria Serra
Marzia Friuli
Viviana Cavallo
Nicola Gammaldi
Daniele Vergara
Michel Salzet
Anna M. Giudetti

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1567543

1,845 views

Original Research

Published on 22 May 2025

Dynamic relationship between gut microbiota and post-necrotizing pancreatitis: insights from a multi-stage 16S rRNA sequencing study

in Gastrointestinal and Hepatic Pharmacology

Jiongdi Lu
Zhe Wang
Feng Cao
Jia Li
Guofeng Ji
Fei Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1577558

1,190 views

Review

Published on 21 May 2025

Vitamin B5 and vitamin U review: justification of combined use for the treatment of mucosa-associated gastrointestinal pathologies

in Gastrointestinal and Hepatic Pharmacology

Valentin P. Shichkin

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1587627

4,290 views

Review

Published on 19 May 2025

Insights into the gut-liver axis: mechanisms and emerging therapies in hepatocellular carcinoma

in Gastrointestinal and Hepatic Pharmacology

Yongjian Hu
Mingming Gao
Jiajin Chenghuang
Rui Bao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1595853

2,352 views

Original Research

Published on 16 May 2025

2-Dodecyl-6-methoxycyclohexa-2,5-dien-1,4-dione alleviates liver fibrosis and improves intestinal flora and bile acid metabolism

in Gastrointestinal and Hepatic Pharmacology

Yongfei He
Thi Thai Hoa Pham
Junming Xu
Shengjie Hong
Jicai Wang
Hang Zhai
Qiang Tao
Ruixi Li
Guangquan Zhang
Xianjie Shi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1581138

1,332 views

Original Research

Published on 15 May 2025

Pan-cancer profiling of FZD2 as a prognostic biomarker: integrative multi-omics analysis with experimental validation and functional characterization in gastric cancer

in Gastrointestinal and Hepatic Pharmacology

Sijiang Zhou
Da Li
Chao Quan
Zhu Yu
Yue Feng
Shengyu Wang
Yong Li
Tongtong Qi
Junqiang Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1534974

2,928 views

Original Research

Published on 13 May 2025

First-line treatment of hepatocellular carcinoma: a propensity-matched analysis of tyrosine kinase inhibitors combined with TACE, with or without PD-1 inhibitors

in Gastrointestinal and Hepatic Pharmacology

Yanjun Shen
Yawen Xu
Ying Teng
Xiaoyan Ding
Jinglong Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1533471

1,164 views

Mini Review

Published on 12 May 2025

Effect of Diquat on gut health: molecular mechanisms, toxic effects, and protective strategies

in Gastrointestinal and Hepatic Pharmacology

Cheng He
Guorong Cai
Yingmao Jia
Rong Jiang
Xiaolan Wei
Ning Tao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1562182

10,649 views

Review

Published on 12 May 2025

Mucoprotectants and gut barrier: mechanisms of action and clinical applications in IBS. Is there a possible role?

in Gastrointestinal and Hepatic Pharmacology

Francesco Rettura
Christian Lambiase
Riccardo Tedeschi
Antonio Grosso
Lorenzo Cancelli
Angelo Ricchiuti
Andrea Bottari
Luca Giacomelli
Nicola de Bortoli
Massimo Bellini

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1538791

1,646 views