REVIEW article
Front. Sports Act. Living
Sec. Physical Activity in the Prevention and Management of Disease
Volume 7 - 2025 | doi: 10.3389/fspor.2025.1595855
Exercise and Triple-Negative Breast Cancer: Mechanisms, Evidence, and Clinical Implications
Provisionally accepted
- 1The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China
- 2Department of Immunology and Microbiology, School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China
- 3Department of Public Physical, Zhejiang Chinese Medical University, Hangzhou, China
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Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer with limited treatment options and a poor prognosis. Exercise has emerged as a promising non-drug intervention due to its safety, low cost, and broad health benefits. This review examines the impact of exercise on TNBC, focusing on different exercise types (aerobic, resistance, and combined) and their underlying mechanisms. Regular moderate-intensity exercise can improve quality of life, reduce tumor burden, and potentially lower the risk of recurrence and mortality. Exercise may also positively affect the tumor environment, immune function, metabolism, and inflammation. However, larger clinical trials focused on TNBC are needed. Future research should aim to optimize exercise interventions and personalize exercise prescriptions based on individual patient characteristics. Integrating evidence-based exercise strategies into clinical practice could improve treatment outcomes and enhance patient well-being in TNBC.
Keywords: TNBC, Exercise, Molecular mechanisms, Hallmarks of cancer, clinical perspectives
Received: 18 Mar 2025; Accepted: 23 Jun 2025.
Copyright: © 2025 Hu, Chen, Wang, Xu, Chen, Tao and Fu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Fangfang Tao, Department of Immunology and Microbiology, School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China
Keqi Fu, Department of Public Physical, Zhejiang Chinese Medical University, Hangzhou, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.