Frontiers in Toxicology

Original Research

Published on 01 Oct 2025

Promoting ethical and reproducible cell culture: implementing animal-free alternatives to teaching in molecular and cell biology

Alexandra Nessar
Viola Röhrs
Mathias Ziersch
Ahmed S. M. Ali
Julia Moradi
Anke Kurreck
Johanna Berg
Jens Kurreck

Frontiers in Toxicology

doi 10.3389/ftox.2025.1670513

4,862 views
1 citation

Original Research

Published on 30 Sep 2025

Acetaldehyde and methylglyoxal: comparative analysis of toxic electronic cigarette degradation products in 3D and 2D exposure systems using human bronchial epithelial models

Man Wong
Teresa Martinez
Nathan Hendricks
Prue Talbot

Frontiers in Toxicology

doi 10.3389/ftox.2025.1624794

4,472 views
1 citation

Original Research

Published on 29 Sep 2025

In Vitro analysis of the effect of mono-(2-ethylhexyl) phthalate (MEHP) exposure on macrophage inflammatory responses in relationship to Leydig cell steroid production

Akhil Adla
Allison Lunney
Barry Zirkin
Kassim Traore

Frontiers in Toxicology

doi 10.3389/ftox.2025.1636395

1,833 views

Review

Published on 29 Sep 2025

Excessive alcohol consumption: a driver of metabolic dysfunction and inflammation

Jaeeun Lee
Ji-Young Lee
Hyunju Kang

Frontiers in Toxicology

doi 10.3389/ftox.2025.1670769

8,354 views
5 citations

Original Research

Published on 26 Sep 2025

From genes to organs: physiological responses of European chub (Squalius cephalus) to chronic PFAS pollution

Sara Pacchini
Laura Drago
Martina Cortese
Giacomo Vanzan
Elisabetta Piva
Shaghayegh Kholdihaghighi
Andrea Barbarossa
Anisa Bardhi
Sophia Schumann
Chiara Fogliano

Frontiers in Toxicology

doi 10.3389/ftox.2025.1654272

1,910 views

Mini Review

Published on 25 Sep 2025

Forensic toxicology of benzodiazepines: neuropharmacological effects, analytical challenges, and emerging detection strategies

Husna Irfan Thalib
Ahmed Abdelghany Damanhory
Ayesha Hanin Shaikh
Shyma Haidar
Sariya Khan
Ayesha Jamal
Omar Ahmed Abdelghany

Frontiers in Toxicology

doi 10.3389/ftox.2025.1639890

4,956 views
1 citation

Original Research

Published on 25 Sep 2025

Implementing a trilineage differentiation in the ReproTracker assay for improved teratogenicity assessment

José M. Horcas-Nieto
Sabine Hartvelt
Luke Flatt
Jing Fang
Esther Lam
Gaonan Zhang
Romy Van Vliet
Marleen Feliksik
Tom Zwetsloot
Connor Philippo

Frontiers in Toxicology

doi 10.3389/ftox.2025.1645842

2,986 views

Review

Published on 19 Sep 2025

Environmental exposure pathways of microplastics and their toxic effects on ecosystems and the nervous system

Kuo Lu
Yixiang Que
Longfei Wang
Yanfan Wang
Jinyan Qiu
Yangyang Jia
Cong Ding
Dazhong Wang
Weyland Cheng
Yaodong Zhang

Frontiers in Toxicology

doi 10.3389/ftox.2025.1649282

4,013 views
1 citation

Original Research

Published on 15 Sep 2025

Daflon and Centrum mitigate vancomycin-induced nephrotoxicity in rats by ameliorating oxidative stress, DNA damage, apoptosis, and inflammation

Hanem F. El-Gendy
Soaad Salamah
Eman Elhusseiny
Hazim O. Khalifa
Hossny A. El-Banna
Taha A. Attia
Shaimaa Selim
Saber El Hanbally

Frontiers in Toxicology

doi 10.3389/ftox.2025.1673083

1,700 views

Original Research

Published on 15 Sep 2025

Error-corrected next-generation sequencing mutagenicity assays in human HepaRG cells as human-relevant genetic toxicology new approach methodology

A. Rasim Barutcu
Nimisha Bhattarai
Raymond Samuel
Jamie Scaglione
Leslie Recio

Frontiers in Toxicology

doi 10.3389/ftox.2025.1657189

2,608 views
1 citation

Review

Published on 09 Sep 2025

Antibody-based alternatives to animal testing for toxin detection and antitoxin evaluation

Seo-Hyuk Chang
Jieun Jang
Wonjun Yang
Nam-Kyung Lee
Seoyeon Choi
Hyo-Il Jung
Wantae Kim
Boksik Cha
Sung-Jin Yoon
Ji-Yoon Noh

Frontiers in Toxicology

doi 10.3389/ftox.2025.1636246

3,414 views

Case Report

Published on 09 Sep 2025

Mercury exposure leading to functional vitamin B12 deficiency and subacute combined degeneration: a case report and literature review

Isidora Semnic
Valentino Rački
Olivia Perković
Vladimira Vuletić

Frontiers in Toxicology

doi 10.3389/ftox.2025.1580275

3,351 views

Original Research

Published on 08 Sep 2025

Occupational exposure and its mechanistic link to allergic asthma and lung function decline; a data-driven approach coupled to mining of adverse outcome pathway signatures

Rob Stierum
Manosij Ghosh
Marjolein Meijerink
Xavier Pinho
Joost Westerhout
Vivi Schlünssen
Anjoeka Pronk
Jolanda van Bilsen

Frontiers in Toxicology

doi 10.3389/ftox.2025.1589380

2,002 views

Original Research

Published on 03 Sep 2025

Exploring plasticisers-osteoporosis links and mechanisms: a cohort and network toxicology study

Xingyao Yang
Xin Wang
Shifu Bao
Zhengjiang Li
Shuxing Xing
Zhangzhen Du

Frontiers in Toxicology

doi 10.3389/ftox.2025.1617663

3,429 views

Review

Published on 29 Aug 2025

The impact of perfumes and cosmetic products on human health: a narrative review

Sharifa Alblooshi

Frontiers in Toxicology

doi 10.3389/ftox.2025.1646075

16,099 views
2 citations

Systematic Review

Published on 25 Aug 2025

Stroke risk following bee and wasp stings: a systematic review of ischemic and hemorrhagic events

Jorge Vasconez-Gonzalez
Juan S. Izquierdo-Condoy
Karen Delgado-Moreira
María de Lourdes Noboa-Lasso
Esteban Gamez-Rivera
Camila Salazar-Santoliva
María Belén Lopez-Molina
Esteban Ortiz-Prado

Frontiers in Toxicology

doi 10.3389/ftox.2025.1632308

3,847 views

Original Research

Published on 21 Aug 2025

Integral approach to organelle profiling in human iPSC-derived cardiomyocytes enhances in vitro cardiac safety classification of known cardiotoxic compounds

Brigitta R. Szabo
Jeroen Stein
Anna Savchenko
Thomas Hutschalik
Filip Van Nieuwerburgh
Tim Meese
Georgios Kosmidis
Paul G. A. Volders
Elena Matsa

Frontiers in Toxicology

doi 10.3389/ftox.2025.1644119

2,553 views

Hypothesis and Theory

Published on 21 Aug 2025

Determining a NOAEL for the consortium linking academic and regulatory insights on BPA toxicity (CLARITY-BPA) core study

Melissa Badding
Noor Aly
Kevin Sondenheimer

Frontiers in Toxicology

doi 10.3389/ftox.2025.1639737

1,995 views

Original Research

Published on 18 Aug 2025

Validation of a novel questionnaire for assessing occupational exposure to organophosphate pesticides in Chilean agricultural workers

Liliana Zúñiga-Venegas
Natalia Landeros
Floria Pancetti
Sandra Cortés
Boris Lucero
Ana M. Brito
Ian S. Acuña-Rodríguez
María Teresa Muñoz-Quezada

Frontiers in Toxicology

doi 10.3389/ftox.2025.1588408

2,249 views
1 citation

Perspective

Published on 11 Aug 2025

Uncovering exposome-related diseases through the pathologic metallome: a novel approach for clinical populations

Riccardo Leinardi
François Huaux

Frontiers in Toxicology

doi 10.3389/ftox.2025.1625874

1,806 views

Original Research

Published on 11 Aug 2025

Assessment of heated herbal products’ tobacco harm reduction potential: pre‐clinical and clinical studies

Alvaro-Flavio Marinas-Lacasta
Ian M. Fearon
Matthew Stevenson
Tasnim Abusalem
Fiona Chapman
Edgar Trelles Sticken
Roman Wieczorek
Sarah Jean Pour
Ole Dethloff
Ourania Komini

Frontiers in Toxicology

doi 10.3389/ftox.2025.1589480

4,665 views

Review

Published on 08 Aug 2025

Fetal bovine serum: how to leave it behind in the pursuit of more reliable science

Tilo Weber
Atena Malakpour-Permlid
Aline Chary
Vito D’Alessandro
Leah Haut
Sebastian Seufert
Esther Veronika Wenzel
James Hickman
Karen Bieback
Joachim Wiest

Frontiers in Toxicology

doi 10.3389/ftox.2025.1612903

11,518 views
11 citations

Original Research

Published on 06 Aug 2025

Epidemiological investigation of venomous snakebites in Yunnan Province

Qinfen Gao
Yajun Teng
Chao Xiao
Rui Zeng
Bin Han
Hong Gao
Jianhai Wang
Xiaoyan Li
Canju Yang
Jianneng Dai

Frontiers in Toxicology

doi 10.3389/ftox.2025.1609487

3,207 views
3 citations

Original Research

Published on 04 Aug 2025

Refinement of a workflow for human relevance assessment of adverse outcome pathways and associated new approach methodologies

Annick D. van den Brand
Julia J. Meerman
Christina H. J. Veltman
Mirjam Luijten

Frontiers in Toxicology

doi 10.3389/ftox.2025.1616817

2,061 views

645 Publications

volumes

Volume 7 - 2025

Promoting ethical and reproducible cell culture: implementing animal-free alternatives to teaching in molecular and cell biology

Acetaldehyde and methylglyoxal: comparative analysis of toxic electronic cigarette degradation products in 3D and 2D exposure systems using human bronchial epithelial models

In Vitro analysis of the effect of mono-(2-ethylhexyl) phthalate (MEHP) exposure on macrophage inflammatory responses in relationship to Leydig cell steroid production

Excessive alcohol consumption: a driver of metabolic dysfunction and inflammation

From genes to organs: physiological responses of European chub (Squalius cephalus) to chronic PFAS pollution

Forensic toxicology of benzodiazepines: neuropharmacological effects, analytical challenges, and emerging detection strategies

Implementing a trilineage differentiation in the ReproTracker assay for improved teratogenicity assessment

Environmental exposure pathways of microplastics and their toxic effects on ecosystems and the nervous system

Daflon and Centrum mitigate vancomycin-induced nephrotoxicity in rats by ameliorating oxidative stress, DNA damage, apoptosis, and inflammation

Error-corrected next-generation sequencing mutagenicity assays in human HepaRG cells as human-relevant genetic toxicology new approach methodology

Antibody-based alternatives to animal testing for toxin detection and antitoxin evaluation

Mercury exposure leading to functional vitamin B12 deficiency and subacute combined degeneration: a case report and literature review

Occupational exposure and its mechanistic link to allergic asthma and lung function decline; a data-driven approach coupled to mining of adverse outcome pathway signatures

Exploring plasticisers-osteoporosis links and mechanisms: a cohort and network toxicology study

The impact of perfumes and cosmetic products on human health: a narrative review

Stroke risk following bee and wasp stings: a systematic review of ischemic and hemorrhagic events

Integral approach to organelle profiling in human iPSC-derived cardiomyocytes enhances in vitro cardiac safety classification of known cardiotoxic compounds

Determining a NOAEL for the consortium linking academic and regulatory insights on BPA toxicity (CLARITY-BPA) core study

Validation of a novel questionnaire for assessing occupational exposure to organophosphate pesticides in Chilean agricultural workers

Uncovering exposome-related diseases through the pathologic metallome: a novel approach for clinical populations

Assessment of heated herbal products’ tobacco harm reduction potential: pre‐clinical and clinical studies

Fetal bovine serum: how to leave it behind in the pursuit of more reliable science

Epidemiological investigation of venomous snakebites in Yunnan Province

Refinement of a workflow for human relevance assessment of adverse outcome pathways and associated new approach methodologies