Integrated PK/PD and Drug Metabolism Approaches in Drug Development and Evaluation

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ORIGINAL RESEARCH

Accepted on 27 Aug 2025

Synthesis, pharmacokinetic studies, and metabolite analysis of meridianin C in rats using a validated ultra high performance liquid chromatography-tandem mass spectrometry method

Liangyu Xu
Karna Ramachandraiah
Zhaogen Wu
Guihun Jiang
Guozhe Zhang

doi 10.3389/fphar.2025.1633157

170 views

ORIGINAL RESEARCH

Published on 19 Aug 2025

Population pharmacokinetics/pharmacodynamics analysis confirming biosimilarity of SB16 to reference denosumab

Seungchan Choi
Suemin Park
Jinah Jung
Siook Baek
Hyeong-Seok Lim

doi 10.3389/fphar.2025.1631034

530 views

ORIGINAL RESEARCH

Published on 29 Apr 2025

Effect of ABCB1 SNP polymorphisms on the plasma concentrations and clinical outcomes of rivaroxaban in Chinese NVAF patients: a population pharmacokinetic-based study

Fei Wang
Ze Li
Youqi Huang
Qin Liu
Libin Zhao
Honghong Wang
Hongjin Gao
Mingyu Chen
Yuze Lin
1 more
Min Chen

doi 10.3389/fphar.2025.1574949

1,511 views

ORIGINAL RESEARCH

Published on 28 Apr 2025

Prediction of pharmacokinetic/pharmacodynamic properties of aldosterone synthase inhibitors at drug discovery stage using an artificial intelligence-physiologically based pharmacokinetic model

Mengjun Zhang
Keheng Wu
Sihui Long
Xiong Jin
Bo Liu

doi 10.3389/fphar.2025.1578117

2,243 views
1 citation

ORIGINAL RESEARCH

Published on 10 Apr 2025

A mechanistic quantitative systems pharmacology model platform for translational efficacy evaluation and checkpoint combination design of bispecific immuno-modulatory antibodies

Yiyang Xu
Siyuan Yang
Qi Rao
Yuan Gao
Guanyue Zhou
Dongmei Zhao
Xinsheng Shi
Yi Chai
Chen Zhao

doi 10.3389/fphar.2025.1571844

1,393 views

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