Advancing pediatric critical care: Sepsis, immune dysregulation, and precision therapies

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ORIGINAL RESEARCH

Published on 19 Nov 2025

Neutrophil dysregulation differentiates pediatric septic shock biomarker-based mortality-risk strata: insights from weighted gene co-expression network and transcriptomic analyses

Leland Dunwoodie
Min Huang
Andrew R. Moore
Natalja L. Stanski
Stephen W. Standage
Jennifer M. Kaplan
Basilia Zingarelli
Kelli Harmon
Julie C. Fitzgerald
10 more
Andrew J. Lautz

doi 10.3389/fimmu.2025.1663704

274 views

ORIGINAL RESEARCH

Published on 14 Nov 2025

Viral-associated septic shock in pediatric pneumonia: a retrospective analysis of pathogen-specific risks and comparative clinical features with bacterial sepsis

Ying Cheng
Kun Chen
Hui-ling Qian
Hong-bo Hu

doi 10.3389/fped.2025.1665453

273 views

ORIGINAL RESEARCH

Published on 07 Nov 2025

Identification of novel phenotypes in pediatric sepsis based on blood glucose trajectories

Ying Wang
Wanqin Song
Shaojun Li
Xianming Xu
Wenjun Liu
Chengjun Liu
Feng Xu
Jing Li

doi 10.3389/fped.2025.1663890

671 views

ORIGINAL RESEARCH

Published on 23 Oct 2025

Machine learning-based time-to-event survival analysis in pediatric patients with severe sepsis

Qianru Huang
Li Zheng
Ruyi Cai
Haiyang Chen

doi 10.3389/fped.2025.1688416

695 views

METHODS

Published on 09 Oct 2025

Evaluation of gestational age, serum amyloid A, and hemoglobin decline (ΔHb) as diagnostic markers for NEC secondary to late-onset sepsis in preterm infants

Yun Cheng
Biquan Chen
Wenjia Tong
Wangqiang Li
Yuanyuan Duan

doi 10.3389/fped.2025.1662371

1,018 views

ORIGINAL RESEARCH

Published on 22 Sep 2025

Risk factors for mortality and development of a predictive model in pediatric sepsis

Caizhen Wang
Lijie Feng
Xiaohui Yang
Pan Wang
Yuan Chen

doi 10.3389/fped.2025.1661086

1,391 views

ORIGINAL RESEARCH

Published on 26 Aug 2025

Construction and efficacy evaluation of a model for early diagnosis of pediatric sepsis based on LASSO-logistic regression

Yan Jiang
Weikai Wang
Ruifeng Xu
Chen Wang
Zhongtao Wang
Xin Wang
Jingguo Zhang
Yanxia Wang

doi 10.3389/fped.2025.1624278

1,003 views

CLINICAL TRIAL

Published on 06 Aug 2025

A randomized controlled trial on the efficacy and safety of vitamin A supplementation in children with sepsis

Qinyi Fu
Maoxia Liu
Xuepeng Zhang
Jianlei Fu
Geng Zhang
Yi Ji
Siyuan Chen

doi 10.3389/fped.2025.1579006

1,915 views
1 citation

ORIGINAL RESEARCH

Published on 24 Jul 2025

A multicentre cross-sectional survey of the core competence of paediatric emergency nurses

Yi Tao
Wenjing Li
Li Zhang
Shuang Zhan
Man Wang
Mei Feng

doi 10.3389/fped.2025.1635942

987 views

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Frontiers in Pediatrics

Pediatric Critical Care

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Articles

Neutrophil dysregulation differentiates pediatric septic shock biomarker-based mortality-risk strata: insights from weighted gene co-expression network and transcriptomic analyses

Viral-associated septic shock in pediatric pneumonia: a retrospective analysis of pathogen-specific risks and comparative clinical features with bacterial sepsis

Identification of novel phenotypes in pediatric sepsis based on blood glucose trajectories

Machine learning-based time-to-event survival analysis in pediatric patients with severe sepsis

Evaluation of gestational age, serum amyloid A, and hemoglobin decline (ΔHb) as diagnostic markers for NEC secondary to late-onset sepsis in preterm infants

Risk factors for mortality and development of a predictive model in pediatric sepsis

Construction and efficacy evaluation of a model for early diagnosis of pediatric sepsis based on LASSO-logistic regression

A randomized controlled trial on the efficacy and safety of vitamin A supplementation in children with sepsis

A multicentre cross-sectional survey of the core competence of paediatric emergency nurses

Frontiers in Pediatrics

Pediatric Critical Care