Wound repair is a complex and dynamic biological process. After an injury, various signalling pathways are activated and coordinated to restore the tissue integrity and homeostasis. Some organisms such as zebrafish and salamander possess the regenerative abilities that completely replace damaged cells and restore the original tissue architecture. In humans, foetal wounds heal in a regenerative manner while adult wounds heal by scarring which is a non-functioning mass of fibrotic tissue. Aberrant scar formation often leads to loss of function and severe psychological morbidities. If a wound does not heal within the usual time because of aging and diabetes, it will lead to a chronic wound and often results in persistent pain, disability and loss of productivity in patients. Given the serious global public health problems resulting from chronic wounds and pathological scarring, there exists great medical needs in exploring novel pharmaceutical approaches to improve wound healing outcomes.
Recently, numerous researches have been focused on understanding the cellular and molecular mechanisms of tissue repair and regeneration. Multiple omics techniques have been utilized to identify some new cell subpopulation and signaling pathways in the development of wound healing and tissue regeneration. Machine-learning and artificial intelligence (AI)-based approaches leveraged during drug discovery has great potential in generating new molecules for regeneration medicines. This Research Topic will present and discuss current and emerging research on the development of advanced materials and novel targets and their applications for promoting tissue repair and improving impaired wound healing. The goal is to provide some views on the translation of experimental discoveries into clinical therapies for treating patients with pathological wounds.
We welcome Original Research, Review, Mini Review and Perspective articles on themes including, but not limited to:
• Mechanism of wound healing, regeneration and scar formation
• Identification of novel biological targets for wound repair and regeneration
• Pro-healing drug discovery using conventional approach or artificial intelligence
• New materials and their therapeutic strategies
Wound repair is a complex and dynamic biological process. After an injury, various signalling pathways are activated and coordinated to restore the tissue integrity and homeostasis. Some organisms such as zebrafish and salamander possess the regenerative abilities that completely replace damaged cells and restore the original tissue architecture. In humans, foetal wounds heal in a regenerative manner while adult wounds heal by scarring which is a non-functioning mass of fibrotic tissue. Aberrant scar formation often leads to loss of function and severe psychological morbidities. If a wound does not heal within the usual time because of aging and diabetes, it will lead to a chronic wound and often results in persistent pain, disability and loss of productivity in patients. Given the serious global public health problems resulting from chronic wounds and pathological scarring, there exists great medical needs in exploring novel pharmaceutical approaches to improve wound healing outcomes.
Recently, numerous researches have been focused on understanding the cellular and molecular mechanisms of tissue repair and regeneration. Multiple omics techniques have been utilized to identify some new cell subpopulation and signaling pathways in the development of wound healing and tissue regeneration. Machine-learning and artificial intelligence (AI)-based approaches leveraged during drug discovery has great potential in generating new molecules for regeneration medicines. This Research Topic will present and discuss current and emerging research on the development of advanced materials and novel targets and their applications for promoting tissue repair and improving impaired wound healing. The goal is to provide some views on the translation of experimental discoveries into clinical therapies for treating patients with pathological wounds.
We welcome Original Research, Review, Mini Review and Perspective articles on themes including, but not limited to:
• Mechanism of wound healing, regeneration and scar formation
• Identification of novel biological targets for wound repair and regeneration
• Pro-healing drug discovery using conventional approach or artificial intelligence
• New materials and their therapeutic strategies
