It has been a pleasure to put together this Research Topic on anti-inflammatory drugs. So far, the response has been much better than expected. This Research Topic seems to have had a real impact. Hopefully, the search for new anti-inflammatory drugs will look more closely at the leads suggested here. The treatment of pain and chronic pain with topical preparations is another area that needs more research.
Anti-inflammatory sesquiterpene and triterpene acids from Mesona procumbens HemsleyHuang et al. Six triterpene acids were identified and found to have anti-inflammatory activity, including mesoeudesmol. These compounds have been overlooked in the past because of concerns about oral bioavailability. Oral use may improve gut inflammation in diseases such as Crohn’s disease. However, recent research has shown that topical treatment of pain and chronic pain is the most effective. Medicines made from this plant might be effective when applied to the skin. The source of these compounds is the plant M. procumbens (also known as Platastoma palustre), which is used for food and medicine in Asia. The very popular food grass jelly is made from this plant. Triterpene acids will become more important in future healthcare.
Potential effect of luteolin, epiafzelechin, and albigenin on rats under cadmium-induced inflammatory insult: In silico and in vivo approachShahzadi et al. Luteolin, epiafzelechin, and albigenin were found to have anti-inflammatory activity in this study. Luteolin and epiafzelechin are flavonoids, and albigenin is a triterpenoid proanthocyanidin. The source of luteolin is Senegalia senegal, gum Arabic, which is used as a food and medicine. The source of albigenin is Albezia lebbeck, which is native to India and Southeast Asia where it is used as a traditional medicine. Epiafzelechin comes from Senegalia chundra, which is used for timber and medicine. The report details the anti-inflammatory activity of the compounds in a cadmium-based model of inflammation. Additionally, computer modeling data of cyclo-oxygenase 2 binding of the compounds are included.
The immunosuppressive effects and mechanisms of loureirin B on collagen-induced arthritis in ratsZou et al. Loureirin B was found to be anti-inflammatory in a rheumatoid arthritis model. The compound is a flavonoid that comes from the traditional Chinese medicine Dracaena cochinchinensis. A synthetic procedure was devised for loureirin B and derivatives that were used in the study. Loureirin B was found to decrease the expression of voltage-gated potassium channels Kv 1.3 on effector memory T cells. This resulted in the depression of inflammatory cytokine expression by these cells. Joint swelling and inflammation were found to decrease in a rheumatoid arthritis model. Memory T cells are abundant in the skin and may be of interest in future research.
Efficacy and safety analysis of midazolam combined with dezocine sedation and analgesia colonoscopy in patients with inflammatory bowel disease: a prospective single-center open studyChen et al. Midazolam and dezocine provide adequate sedation during colonoscopy. This is useful in a clinical setting where anesthesiologists may not be available. Dezocine is an opioid drug that was discontinued in the United States in 2011 because it causes more respiratory depression than some other opioids. It is used in combination with the benzodiazepine midazolam to induce a twilight sleep type of anesthesia. Dezocine is widely used in China and is considered to be safer than fentanyl, which is the drug of choice in the United States. More than 100,000 patients die from opioids in the United States yearly. A safer approach must be found.
A review of FDA approved drugs and their formulations for the treatment of breast cancerChaurasia et al. This is a thorough review of anti-inflammatory and other drugs used in breast cancer. Breast cancer was diagnosed in 2.3 million women in 2022 and accounted for 685,00 deaths. A useful table of 39 drugs used in breast cancer provides details of each of them. New drug formulations, some of which are in clinical trials, are discussed.
Statements
Author contributions
JA: Writing–original draft. JS: Writing–review and editing. G-SB: Writing–review and editing. AA: Writing–review and editing. MS: Writing–review and editing. MA: Writing–review and editing.
Funding
The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher’s note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
Summary
Keywords
plant medicines, flavonoids, triterpenes, opioids, Benzodiazepines
Citation
Silva J, Bae G-S, Abdel Moneim AE, Saeed M, Adams JD and Ashour ML (2023) Editorial: Hot topic: anti-inflammatory drug discovery. Front. Chem. 11:1339736. doi: 10.3389/fchem.2023.1339736
Received
16 November 2023
Accepted
23 November 2023
Published
15 December 2023
Volume
11 - 2023
Edited and reviewed by
Michael Kassiou, The University of Sydney, Australia
Updates
Copyright
© 2023 Silva, Bae, Abdel Moneim, Saeed, Adams and Ashour.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: James David Adams, jadams@usc.edu
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.