Frontiers in Bioengineering and Biotechnology | Tissue Engineering and Regenerative Medicine

Review

Published on 25 Aug 2025

Progress in immunoregulatory mechanisms during distraction osteogenesis

in Tissue Engineering and Regenerative Medicine

Shiyu Huang
Aoran Zeng
Qing Yin
Qiming Yang
Bing Zou
Meiying He
Juehan Wang
Qi Pan

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1665192

2,900 views

Original Research

Published on 21 Aug 2025

Dynamic male mouse gut microbiota signature linked to improved wound healing of a novel salecan hydrogel dressing

in Tissue Engineering and Regenerative Medicine

Guangping Luo
Tongtong Zhang
Yanan Jiang
Yuan Qin
Pengfei Chen
Junqing Hu

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1584976

1,804 views

Original Research

Published on 21 Aug 2025

Exosomal coactivator-associated arginine methyltransferase 1 derived from adipocytes accelerates diabetic wound healing by modulating inflammation and promoting angiogenesis

in Tissue Engineering and Regenerative Medicine

Yongxiang Zhang
Yao Pan
Kai Yang
Xiansun Wu
Yaoyao Zhang
Fengbiao Xu
Tietao Di
Wang Liu

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1610806

1,912 views

Original Research

Published on 14 Aug 2025

EP4 receptor stimulation in combination with core decompression therapy enhanced bone regeneration in a canine model of osteonecrosis of femoral head

in Tissue Engineering and Regenerative Medicine

Kyoko Hirano
Takaki Miyagawa
Masahiro Nishida
Haruhiko Akiyama

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1622918

2,531 views

Original Research

Published on 11 Aug 2025

Jawbone mesenchymal stromal cells attenuate acute inflammation via hematopoietic niche reinforcement

in Tissue Engineering and Regenerative Medicine

Xinyu Wang
Qianye Chen
Jiping Sun
Zihan Huang
Zijian Zhang
Tingwei Lu
Xiangru Huang
Siyuan Sun
Yuanqi Liu
Houwen Pan

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1596143

2,436 views

Original Research

Published on 11 Aug 2025

Electrospun textiles from decellularized bovine pericardium and polyvinyl alcohol (PVA) supporting blood coagulation: innovative approach in biomaterials for research purposes

in Tissue Engineering and Regenerative Medicine

Luca Di Nunno
Veronica Pagani
Elena Canciani
Gerardina Ruocco
Mattia Spedicati
Maria Talmon
Luca Fusaro
Dalila Di Francesco
Simona Casarella
Manuela Rizzi

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1539759

2,023 views

Hypothesis and Theory

Published on 11 Aug 2025

Platelet-rich plasma may accelerate diabetic wound healing by modulating epithelial/endothelial-mesenchymal transition through inhibiting reactive oxygen species-mediated oxidative stress

in Tissue Engineering and Regenerative Medicine

Youan Li
Biao Cheng
Ju Tian

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1623780

2,967 views
5 citations

Original Research

Published on 08 Aug 2025

Laminin-derived peptide drives the cardiomyogenic potential and cardiac cells functionality

in Tissue Engineering and Regenerative Medicine

Simona Casarella
Federica Ferla
Dalila Di Francesco
Veronica Pagani
Carolina Di Varsavia
Irene Regano
Francesca Boccafoschi

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1629412

2,385 views

Review

Published on 08 Aug 2025

Menstrual blood-derived mesenchymal stromal cell extracellular vesicles – a potential tool for tissue regeneration and disease detection

in Tissue Engineering and Regenerative Medicine

Raminta Vaiciuleviciute
Jolita Pachaleva
Eiva Bernotiene
Gabija Kugaudaite
Ignas Lebedis
Edvinas Krugly
Ilona Uzieliene

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1643408

4,613 views
4 citations

Original Research

Published on 08 Aug 2025

Innate immune pathway activation to modulate mesenchymal stromal cell (MSC) interactions with synovium and cartilage

in Tissue Engineering and Regenerative Medicine

Peter Linde
Lyndah Chow
Isabella Sabino
Zoë Williams
Renata Impastato
Steven Dow
Lynn Pezzanite

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1605148

2,577 views

Original Research

Published on 08 Aug 2025

Connexin 43 suppression enhances contractile force in human iPSC-derived cardiac tissues

in Tissue Engineering and Regenerative Medicine

Takuma Takada
Katsuhisa Matsuura
Tatsuro Iida
Toshiharu Koike
Hidekazu Sekine
Yuhei Higashi
Tsukasa Hara
Daisuke Sasaki
Kyohei Fujita
Yuto Hinata

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1615953

2,741 views

Original Research

Published on 04 Aug 2025

Isolation, characterization, and vascular potential of porcine cells in a three-dimensional decellularized liver matrix model

in Tissue Engineering and Regenerative Medicine

Sara Morini
Sandra Melitón Barbancho
Álvaro Blanes Rodríguez
Iris Pla-Palacín
Pilar Sainz-Arnal
Natalia Sánchez-Romero
Maria Victoria Falceto
Olga Mitjana
Antonio Romero
Marcela Del Rio-Nechaevsky

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1625999

2,344 views

Original Research

Published on 04 Aug 2025

Challenges and limitations in developing of a new maxillary standardized rat alveolar bone defect model to study bone regenerative approaches in oral and maxillofacial surgery

in Tissue Engineering and Regenerative Medicine

Naïma Ahmed Omar
Jéssica Roque
Céline Bergeaut
Laurent Bidault
Joëlle Amédée
Didier Letourneur
Jean-Christophe Fricain
Mathilde Fenelon

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1494352

2,191 views
1 citation

Review

Published on 30 Jul 2025

From bench to bedside: translating mesenchymal stem cell therapies through preclinical and clinical evidence

in Tissue Engineering and Regenerative Medicine

Jai Chand Patel
Meenakshi Shukla
Manish Shukla

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1639439

8,527 views
18 citations

Original Research

Published on 29 Jul 2025

Bioadhesive chitosan hydrogel with dynamic covalent bonds and sustained kartogenin release for endogenous cartilage regeneration

in Tissue Engineering and Regenerative Medicine

Mingjing Li
Fan Li
Jian Xu
Li Zhu
Jiang Xiang
Chunquan Zhu
Zonghui Dai
Sen Tang
Fucheng Ouyang
Jiawen Yu

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1606726

2,778 views
2 citations

Original Research

Published on 28 Jul 2025

Restoration of tendon repair microenvironment by grapefruit exosome-loaded microneedle system for tendinopathy therapy

in Tissue Engineering and Regenerative Medicine

Yuan Zhang
Ruiyang Zhang
Ti Zhang
Yuhao Mu
Talante Juma
Xu Li
Hao Li
Quanyi Guo
Yongping Cao

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1615650

4,159 views

Original Research

Published on 23 Jul 2025

3D-printed polycaprolactone combined with cartilage acellular matrix tissue engineered cartilage scaffold manufactured by low-temperature deposition manufacturing

in Tissue Engineering and Regenerative Medicine

Zhen Song
Xulong Zhang
Yihao Xu
Jingyuan Ji
Wei Sun
Fei Fan
Jianjun You
Yuan Pang

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1604515

2,043 views

Review

Published on 23 Jul 2025

Physical cues in biomaterials modulate macrophage polarization for bone regeneration: a review

in Tissue Engineering and Regenerative Medicine

Tianxiao Yang
Zhurun Fang
Jin Zhang
Shengnai Zheng

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1640560

5,009 views
5 citations

Review

Published on 21 Jul 2025

Modern experimental methods for assessing the effectiveness of tissue-engineered products for hyaline cartilage regeneration

in Tissue Engineering and Regenerative Medicine

M. S. Bozhokin
Yu. S. Korneva
S. A. Bozhkova
E. R. Mikhaylova
D. M. Marchenko
B. R. Rakhimov
Y. A. Nashchekina
M. G. Khotin

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1595116

3,055 views

Original Research

Published on 15 Jul 2025

In vitro and in vivo evaluation of immortalized hepatocyte encapsulated click-microbeads with RGD peptide for treatment of liver failure in male rats

in Tissue Engineering and Regenerative Medicine

Su Yee Win
Pinunta Nittayacharn
Jatupoom Ngernmark
Mongkol Chavalitsarot
Chitinart Thedrattanawong
Khanit Sa-ngiamsuntorn
Suradej Hongeng
Norased Nasongkla

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1629228

2,003 views

Original Research

Published on 14 Jul 2025

Integration of co-culture conditions and 3D gelatin methacryloyl hydrogels to improve human-induced pluripotent stem cells-derived cardiomyocytes maturation

in Tissue Engineering and Regenerative Medicine

Ilaria Gisone
Monica Boffito
Elisa Persiani
Roberta Pappalardo
Elisa Ceccherini
Andrea Alliaud
Manuela Cabiati
Rossella Laurano
Letizia Guiducci
Chiara Caselli

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1576824

3,464 views
3 citations

Review

Published on 14 Jul 2025

Tissue engineering strategies for treating intervertebral disc degeneration

in Tissue Engineering and Regenerative Medicine

Guangshuai Nie
Weiyang Liu
Fanjia Zeng
Jia Hu
Zhen Wang
Zhonglian Huang
Hongjiang Chen
Jun Hu
Jiankun Xu

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1582189

4,003 views
2 citations

Original Research

Published on 10 Jul 2025

Biological effects of exosomes derived from 2D and 3D culture adipose stem cells on JEC Cell proliferation and migration

in Tissue Engineering and Regenerative Medicine

Yifen Li
Gangwei Wang
Yi Zhang
Tao Xu
Xuefeng Jiang

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1541150

2,230 views
1 citation

Original Research

Published on 09 Jul 2025

Olfactory mucosal mesenchymal stem cells delivered by gelatin sponge scaffolds promote functional recovery of spinal cord injury

in Tissue Engineering and Regenerative Medicine

Wenshui Li
Xinchen Jiang
Shuo Lu
Wen Lu
Shanshan Ma
Yi Zhuo
Qingtao Gao
Yi Xiao
Binqian Wu
Junyang Xie

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1628758

2,395 views

1,189 articles

articles

Progress in immunoregulatory mechanisms during distraction osteogenesis

Dynamic male mouse gut microbiota signature linked to improved wound healing of a novel salecan hydrogel dressing

Exosomal coactivator-associated arginine methyltransferase 1 derived from adipocytes accelerates diabetic wound healing by modulating inflammation and promoting angiogenesis

EP4 receptor stimulation in combination with core decompression therapy enhanced bone regeneration in a canine model of osteonecrosis of femoral head

Jawbone mesenchymal stromal cells attenuate acute inflammation via hematopoietic niche reinforcement

Electrospun textiles from decellularized bovine pericardium and polyvinyl alcohol (PVA) supporting blood coagulation: innovative approach in biomaterials for research purposes

Platelet-rich plasma may accelerate diabetic wound healing by modulating epithelial/endothelial-mesenchymal transition through inhibiting reactive oxygen species-mediated oxidative stress

Laminin-derived peptide drives the cardiomyogenic potential and cardiac cells functionality

Menstrual blood-derived mesenchymal stromal cell extracellular vesicles – a potential tool for tissue regeneration and disease detection

Innate immune pathway activation to modulate mesenchymal stromal cell (MSC) interactions with synovium and cartilage

Connexin 43 suppression enhances contractile force in human iPSC-derived cardiac tissues

Isolation, characterization, and vascular potential of porcine cells in a three-dimensional decellularized liver matrix model

Challenges and limitations in developing of a new maxillary standardized rat alveolar bone defect model to study bone regenerative approaches in oral and maxillofacial surgery

From bench to bedside: translating mesenchymal stem cell therapies through preclinical and clinical evidence

Bioadhesive chitosan hydrogel with dynamic covalent bonds and sustained kartogenin release for endogenous cartilage regeneration

Restoration of tendon repair microenvironment by grapefruit exosome-loaded microneedle system for tendinopathy therapy

3D-printed polycaprolactone combined with cartilage acellular matrix tissue engineered cartilage scaffold manufactured by low-temperature deposition manufacturing

Physical cues in biomaterials modulate macrophage polarization for bone regeneration: a review

Modern experimental methods for assessing the effectiveness of tissue-engineered products for hyaline cartilage regeneration

In vitro and in vivo evaluation of immortalized hepatocyte encapsulated click-microbeads with RGD peptide for treatment of liver failure in male rats

Integration of co-culture conditions and 3D gelatin methacryloyl hydrogels to improve human-induced pluripotent stem cells-derived cardiomyocytes maturation

Tissue engineering strategies for treating intervertebral disc degeneration

Biological effects of exosomes derived from 2D and 3D culture adipose stem cells on JEC Cell proliferation and migration

Olfactory mucosal mesenchymal stem cells delivered by gelatin sponge scaffolds promote functional recovery of spinal cord injury