Frontiers in Cellular Neuroscience | Cellular Neuropathology

Review

Published on 10 Nov 2025

Microglia-orchestrated neuroinflammation and synaptic remodeling: roles of pro-inflammatory cytokines and receptors in neurodegeneration

in Cellular Neuropathology

Guang Yang
Xiao Xu
Waimao Gao
Xingyu Wang
Yan Zhao
Ying Xu

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1700692

3,379 views
9 citations

Review

Published on 07 Nov 2025

Microglial TREM2 and cognitive impairment: insights from Alzheimer’s disease with implications for spinal cord injury and AI-assisted therapeutics

in Cellular Neuropathology

Zhonghan Wu
Shuisheng Yu
Dasheng Tian
Li Cheng
Juehua Jing

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1705069

2,228 views

Original Research

Published on 03 Nov 2025

Neuroprotection of IGF-1 in neonatal hypoxic-ischemic brain injury through downregulation of FoXO3a-PUMA pathway

in Cellular Neuropathology

Yanli Tang
Rui Zhong
Jiayi Liang
Shuang Liu
Wanxia Liu
Tao Liu
Baohong Yuan
Mengya Jiao
Hui Yin

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1685800

1,774 views

Review

Published on 03 Nov 2025

Traditional Chinese medicine’s holistic approach: regulating microglia-driven neuroinflammation for the resolution of Alzheimer’s disease

in Cellular Neuropathology

Jialing Yu
Xinya Bao
Chuchu Shan
Zebin Yu
Yajie Yu
Hongying Wang
Yuyan Zhang

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1691253

2,097 views

Review

Published on 31 Oct 2025

Direct and indirect role of non-coding RNAs in company with amyloid and tau protein in promoting neuroinflammation in post-ischemic brain neurodegeneration

in Cellular Neuropathology

Ryszard Pluta

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1670462

1,569 views
2 citations

Editorial

Published on 28 Oct 2025

Editorial: Methods in cellular neurobiology research

in Cellular Neuropathology

Sue Han
Adalberto Merighi
Cheng Wang
Shrijeet Chakraborti

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1713920

1,610 views

Review

Published on 28 Oct 2025

TDP-43-proteinopathy at the crossroads of tauopathy: on copathology and current and prospective biomarkers

in Cellular Neuropathology

Abdul R. Nasir
Claire Delpirou Nouh

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1671419

3,053 views

Original Research

Published on 28 Oct 2025

Ceftriaxone attenuates Poly I:C–induced neuroinflammation in vitro by modulating glutamate transport, synaptic integrity, and immunometabolic reprogramming

in Cellular Neuropathology

Xizi Shi
Yesheng Sun
Shirin Hosseini
Fangfang Chen
Thekla Cordes
Kristin Michaelsen-Preusse
Martin Korte

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1684398

1,685 views

Original Research

Published on 27 Oct 2025

Analysis of microRNA-transcript regulatory networks in the hippocampus of the BTBR mouse model of autism

in Cellular Neuropathology

Silvia Gasparini
Valerio Licursi
Arianna Rinaldi
Laura Ricceri
Maria Luisa Scattoni
Carlo Presutti
Cecilia Mannironi

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1676316

1,404 views

Brief Research Report

Published on 17 Oct 2025

Psychological trauma increases blood pressure sensitivity to angiotensin II via T-lymphocytes independent of psychopathology

in Cellular Neuropathology

Adam J. Case
Tamara Natour
Lauren J. Pitts
Tatlock H. Lauten
Emily C. Reed
Cassandra M. Moshfegh
Safwan K. Elkhatib

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1691047

1,493 views

Review

Published on 16 Oct 2025

CRISPR-Cas9: bridging the gap between aging mechanisms and therapeutic advances in neurodegenerative disorders

in Cellular Neuropathology

Anas Shamsi
Mohammed Alrouji
Othman AlOmeir
Syed Tasqeruddin
Khuzin Dinislam
Azna Zuberi

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1681891

4,093 views

Original Research

Published on 15 Oct 2025

Galactin-3 regulation of CDC42 promotes neuronal autophagy following spinal cord injury

in Cellular Neuropathology

Lei Yan
Xun Zhou
Qianqiu Li
Hongxiang Hong
Chunshuai Wu
Yong-Jing Gao
Zhiming Cui
Guanhua Xu

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1622825

2,658 views

Original Research

Published on 15 Oct 2025

SOD mediates mitochondrial epigenetic regulation in NIHL

in Cellular Neuropathology

Liuwei Shi
Caiping Li
Dianpeng Wang
Dafeng Lin
Xiangli Yang
Peimao Li
Wen Zhang
Yan Guo
Liting Zhou
Naixing Zhang

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1673070

2,247 views

Review

Published on 08 Oct 2025

Wrap it up: myelination of transplanted neurons for repair

in Cellular Neuropathology

María Fernanda Martínez-Reza
Magdalena Götz

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1635551

2,760 views

Original Research

Published on 07 Oct 2025

Dual role of Lyz2-positive myeloid cells in traumatic brain injury: acute anti-inflammatory effects vs. chronic neurological deterioration

in Cellular Neuropathology

Hua-Zheng Yan
Yi-Wan Fang
Shi-Yu Zhou
Jian-Xiong Gao
Ming-Ming Bian
Yao-Mei Xu
Lin Zhang
Nan Zhang
He-Zuo Lü

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1642410

2,852 views

Original Research

Published on 30 Sep 2025

THC reverses SIV-induced senescence in astrocytes: possible compensatory mechanism against HIV associated brain injury?

in Cellular Neuropathology

Alison R. Van Zandt
Miranda D. Horn
Tiffany A. Peterson
Sarah Y. Dickinson
Elise M. Frost
Andrew G. MacLean

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1642917

2,818 views
2 citations

Original Research

Published on 25 Sep 2025

A mutational hotspot in TUBB2A associated with impaired heterodimer formation and severe brain developmental disorders

in Cellular Neuropathology

Gabriele Di Pasquale
Jacopo Colella
Carola P. Di Cataldo
Miguel A. Soler
Sara Fortuna
Emma Mizrahi-Powell
Mathilde Nizon
Benjamin Cognè
Valentina Turchetti
Giuseppe D. Mangano

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1664953

3,469 views

Brief Research Report

Published on 25 Sep 2025

Brain-derived neurotrophic factor prevents LPS-induced dysregulation of GABAergic interneuron markers in mouse hippocampus

in Cellular Neuropathology

Sara Rezaei
Mounira Banasr
Thomas D. Prevot
Yashika Bansal
Erica Vieira
Etienne Sibille

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1675003

2,848 views

Review

Published on 25 Sep 2025

The role of small GTPases in Alzheimer’s disease tau pathologies

in Cellular Neuropathology

Peter Hoegy
Yan-Hua Chen
Qun Lu

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1650400

2,662 views

Original Research

Published on 24 Sep 2025

Sex-specific interneuron vulnerability after traumatic brain injury correlates with neurotrophic signaling and chloride homeostasis, independent of behavioral and network outcomes

in Cellular Neuropathology

Amandine Consumi
Cécile Marcourt
Tayam Tnaimou
Jérôme Laurin
Michael K. E. Schäfer
Christophe Pellegrino
Claudio Rivera

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1572213

2,346 views

Original Research

Published on 23 Sep 2025

Lactate infusion increases circulating pro-brain-derived neurotrophic factor levels in humans

in Cellular Neuropathology

Julia Röja
Nicolas Fiori Ameller
Jonathan Grip
William Apró
Marcus Moberg

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1644843

5,270 views

Review

Published on 18 Sep 2025

Spatiotemporal crosstalk among mitochondrial dynamics, NLRP3 inflammasome activation, and histone lactylation drives α-synuclein pathology in prodromal Parkinson’s disease

in Cellular Neuropathology

Peizhu Lv
Xia Chen
Shiping Liu
Yu Zhang
Yan Bai
Shun Wang
Yulin Wang

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1636185

6,181 views

Original Research

Published on 16 Sep 2025

Boldine as a neuroprotective agent against motor neuron degeneration in models of amyotrophic lateral sclerosis

in Cellular Neuropathology

Carlos A. Toro
Wei Zhao
Patricio Garcia Silva
Daniela Retamal-Santibáñez
Fabiola Rojas
Jiangping Pan
Nicholas Johnson
Yorley Duarte
Christopher P. Cardozo
Juan C. Sáez

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1640590

3,271 views
1 citation

Original Research

Published on 12 Sep 2025

Establishment of human Leber’s hereditary optic neuropathy model using iPSC-derived retinal organoids

in Cellular Neuropathology

Kota Aoshima
Yuya Takagi
Michinori Funato
Yoshiki Kuse
Shinsuke Nakamura
Masamitsu Shimazawa

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1635775

3,616 views

2,080 articles

articles

Microglia-orchestrated neuroinflammation and synaptic remodeling: roles of pro-inflammatory cytokines and receptors in neurodegeneration

Microglial TREM2 and cognitive impairment: insights from Alzheimer’s disease with implications for spinal cord injury and AI-assisted therapeutics

Neuroprotection of IGF-1 in neonatal hypoxic-ischemic brain injury through downregulation of FoXO3a-PUMA pathway

Traditional Chinese medicine’s holistic approach: regulating microglia-driven neuroinflammation for the resolution of Alzheimer’s disease

Direct and indirect role of non-coding RNAs in company with amyloid and tau protein in promoting neuroinflammation in post-ischemic brain neurodegeneration

Editorial: Methods in cellular neurobiology research

TDP-43-proteinopathy at the crossroads of tauopathy: on copathology and current and prospective biomarkers

Ceftriaxone attenuates Poly I:C–induced neuroinflammation in vitro by modulating glutamate transport, synaptic integrity, and immunometabolic reprogramming

Analysis of microRNA-transcript regulatory networks in the hippocampus of the BTBR mouse model of autism

Psychological trauma increases blood pressure sensitivity to angiotensin II via T-lymphocytes independent of psychopathology

CRISPR-Cas9: bridging the gap between aging mechanisms and therapeutic advances in neurodegenerative disorders

Galactin-3 regulation of CDC42 promotes neuronal autophagy following spinal cord injury

SOD mediates mitochondrial epigenetic regulation in NIHL

Wrap it up: myelination of transplanted neurons for repair

Dual role of Lyz2-positive myeloid cells in traumatic brain injury: acute anti-inflammatory effects vs. chronic neurological deterioration

THC reverses SIV-induced senescence in astrocytes: possible compensatory mechanism against HIV associated brain injury?

A mutational hotspot in TUBB2A associated with impaired heterodimer formation and severe brain developmental disorders

Brain-derived neurotrophic factor prevents LPS-induced dysregulation of GABAergic interneuron markers in mouse hippocampus

The role of small GTPases in Alzheimer’s disease tau pathologies

Sex-specific interneuron vulnerability after traumatic brain injury correlates with neurotrophic signaling and chloride homeostasis, independent of behavioral and network outcomes

Lactate infusion increases circulating pro-brain-derived neurotrophic factor levels in humans

Spatiotemporal crosstalk among mitochondrial dynamics, NLRP3 inflammasome activation, and histone lactylation drives α-synuclein pathology in prodromal Parkinson’s disease

Boldine as a neuroprotective agent against motor neuron degeneration in models of amyotrophic lateral sclerosis

Establishment of human Leber’s hereditary optic neuropathy model using iPSC-derived retinal organoids