Frontiers in Chemistry | Medicinal and Pharmaceutical Chemistry

Original Research

Published on 13 Sep 2024

Phytochemical analysis, identification of bioactive compounds using GC-MS, in vitro and in silico hypoglycemic potential, in vitro antioxidant potential, and in silico ADME analysis of Chlorophytum comosum root and leaf

in Medicinal and Pharmaceutical Chemistry

P. Kavya
R. C. Theijeswini
M. Gayathri

Frontiers in Chemistry

doi 10.3389/fchem.2024.1458505

3,484 views
4 citations

Original Research

Published on 13 Sep 2024

Phytochemical profile, physicochemical, antioxidant and antimicrobial properties of Juniperus phoenicea and Tetraclinis articulate: in vitro and in silico approaches

in Medicinal and Pharmaceutical Chemistry

Ayoub Asbabou
Touijer Hanane
Aman Allah Gourich
Farhan Siddique
Aziz Drioiche
Firdaous Remok
Soukaina Saidi
Imad Adadi
Hamid Khamar
Khalid S. Almaary

Frontiers in Chemistry

doi 10.3389/fchem.2024.1397961

3,212 views
2 citations

Original Research

Published on 10 Sep 2024

Salsoline derivatives, genistein, semisynthetic derivative of kojic acid, and naringenin as inhibitors of A42R profilin-like protein of monkeypox virus: in silico studies

in Medicinal and Pharmaceutical Chemistry

Mohamed Chebaibi
Mohammed Bourhia
Fatima ez-zahra Amrati
Meryem Slighoua
Ibrahim Mssillou
Mourad A. M. Aboul-Soud
Asaad Khalid
Rym Hassani
Dalila Bousta
Sanae Achour

Frontiers in Chemistry

doi 10.3389/fchem.2024.1445606

2,758 views
5 citations

Original Research

Published on 06 Sep 2024

Design and synthesis new indole-based aromatase/iNOS inhibitors with apoptotic antiproliferative activity

in Medicinal and Pharmaceutical Chemistry

Lamya H. Al-Wahaibi
Hesham A. Abou-Zied
Mostafa H. Abdelrahman
Martha M. Morcoss
Laurent Trembleau
Bahaa G. M. Youssif
Stefan Bräse

Frontiers in Chemistry

doi 10.3389/fchem.2024.1432920

2,796 views
4 citations

Original Research

Published on 30 Aug 2024

Design and synthesis of new 1,2,4-oxadiazole/quinazoline-4-one hybrids with antiproliferative activity as multitargeted inhibitors

in Medicinal and Pharmaceutical Chemistry

Amira M. Mohamed
Ola M. F. Abou-Ghadir
Yaser A. Mostafa
Kholood A. Dahlous
Stefan Bräse
Bahaa G. M. Youssif

Frontiers in Chemistry

doi 10.3389/fchem.2024.1447618

21,182 views
7 citations

Original Research

Published on 21 Aug 2024

Molecular insights into kaempferol derivatives as potential inhibitors for CDK2 in colon cancer: pharmacophore modeling, docking, and dynamic analysis

in Medicinal and Pharmaceutical Chemistry

Fei Xing
Zhicheng Wang
Noor Bahadar
Can Wang
Xu-Dong Wang

Frontiers in Chemistry

doi 10.3389/fchem.2024.1440196

2,505 views
3 citations

Original Research

Published on 16 Aug 2024

Bactericidal, anti-hemolytic, and anticancerous activities of phytofabricated silver nanoparticles of glycine max seeds

in Medicinal and Pharmaceutical Chemistry

K. B. Vijendra Kumar
Kavitha Raj Varadaraju
Prasanna D. Shivaramu
C. M. Hemanth Kumar
H. R. Prakruthi
B. M. Chandra Shekara
Bhargav Shreevatsa
Tanveer A. Wani
K. C. Prakasha
Shiva Prasad Kollur

Frontiers in Chemistry

doi 10.3389/fchem.2024.1427797

2,837 views
3 citations

Original Research

Published on 13 Aug 2024

Structural analogs of 2-(4-fluorophenyl)-6-methyl-3-(pyridin-4-yl)pyrazolo[1,5-a]pyridine for targeting Candida albicans non-essential stress kinase Yck2 through protein-ligand binding and dynamics analysis

in Medicinal and Pharmaceutical Chemistry

Ahmed M. Hassan
Aiah M. Khateb
Safaa A. Turkistani
Meshari M. Alhamdan
Raed M. Garout
Vivek Dhar Dwivedi
Esam I. Azhar

Frontiers in Chemistry

doi 10.3389/fchem.2024.1430157

3,631 views
4 citations

Original Research

Published on 12 Aug 2024

Computational insights into rational design and virtual screening of pyrazolopyrimidine derivatives targeting Janus kinase 3 (JAK3)

in Medicinal and Pharmaceutical Chemistry

Abdelmoujoud Faris
Ivana Cacciatore
Radwan Alnajjar
Adnane Aouidate
Mohammed H. AL Mughram
Menana Elhallaoui

Frontiers in Chemistry

doi 10.3389/fchem.2024.1425220

5,649 views
2 citations

Original Research

Published on 08 Aug 2024

Mechanism investigation of highly selective inhibitors toward phosphodiesterase 5 and 6 via the in vitro calculation and simulation

in Medicinal and Pharmaceutical Chemistry

Lihang Qu
Kaijian Sun
Zhouyu Jiang
Ting Wang
Linlin Chen
Chunjian Shen
Ruidong Gu

Frontiers in Chemistry

doi 10.3389/fchem.2024.1400886

1,899 views
1 citation

Original Research

Published on 07 Aug 2024

Identification of 2-(N-aryl-1,2,3-triazol-4-yl) quinoline derivatives as antitubercular agents endowed with InhA inhibitory activity

in Medicinal and Pharmaceutical Chemistry

Ahmed Sabt
Maha-Hamadien Abdulla
Manal S. Ebaid
Jakub Pawełczyk
Hayam A. Abd El Salam
Ninh The Son
Nguyen Xuan Ha
Mansoor-Ali Vaali Mohammed
Thamer Traiki
Ahmed E. Elsawi

Frontiers in Chemistry

doi 10.3389/fchem.2024.1424017

3,896 views
9 citations

Original Research

Published on 06 Aug 2024

Pyridylpiperazine-based carbodithioates as urease inhibitors: synthesis and biological evaluation

in Medicinal and Pharmaceutical Chemistry

Muhammad Akash
Nehal Rana
Sana Aslam
Matloob Ahmad
Muhammad Jawwad Saif
Aneeza Asghar
Sadia Sultan
Sami A. Al-Hussain
Afifa Liaqat
Sumera Zaib

Frontiers in Chemistry

doi 10.3389/fchem.2024.1423385

2,495 views

Original Research

Published on 06 Aug 2024

Exploring novel Apalutamide analogues as potential therapeutics for prostate cancer: design, molecular docking investigations and molecular dynamics simulation

in Medicinal and Pharmaceutical Chemistry

Ajay Kumar Gupta
Yogesh Vaishnav
Sanmati Kumar Jain
Sivakumar Annadurai
Neeraj Kumar

Frontiers in Chemistry

doi 10.3389/fchem.2024.1418975

2,530 views
2 citations

Original Research

Published on 29 Jul 2024

ROS1 kinase inhibition reimagined: identifying repurposed drug via virtual screening and molecular dynamics simulations for cancer therapeutics

in Medicinal and Pharmaceutical Chemistry

Mohammed Alrouji
Sabina Yasmin
Fahad A Alhumaydhi
Sharaf E. Sharaf
Moyad Shahwan
Anas Shamsi

Frontiers in Chemistry

doi 10.3389/fchem.2024.1392650

1,749 views

Original Research

Published on 25 Jul 2024

Design, synthesis, and bioevaluation of diarylpyrimidine derivatives as novel microtubule destabilizers

in Medicinal and Pharmaceutical Chemistry

Yutao Xiu
Yujing Zhang
Shanbo Yang
Lingyu Shi
Dongming Xing
Chao Wang

Frontiers in Chemistry

doi 10.3389/fchem.2024.1447831

1,747 views

Original Research

Published on 22 Jul 2024

Synthesis and In vitro evaluation of bichalcones as novel anti-toxoplasma agents

in Medicinal and Pharmaceutical Chemistry

Flaminia Mazzone
Moritz K. T. Klischan
Julian Greb
Sander H. J. Smits
Jörg Pietruszka
Klaus Pfeffer

Frontiers in Chemistry

doi 10.3389/fchem.2024.1406307

1,983 views
2 citations