Frontiers in Endocrinology | Systems Endocrinology

Review

Published on 10 Sep 2025

Metabolic and genetic mechanisms of metabolic dysfunction-associated steatotic liver disease: an integrative perspective from molecular pathways to clinical challenges

in Systems Endocrinology

Jingyuan Ma
Yanna Ma
Xing Wan
Junchen Li
Yunshu Zhang
Jifeng Liu
Yunhai Gao

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1639064

5,006 views
1 citation

Correction

Published on 05 Sep 2025

Correction: Triglyceride-glucose index and periodontitis: evidence from two population-based surveys

in Systems Endocrinology

Jing Huang
Dan Zhang
Hua Li
Yiyun Zhang
Tianxue Long
Xiaojing Guo
Hangyu Cui
Zixuan Wei
Jun Zhao
Mingzi Li

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1686929

1,851 views

Original Research

Published on 02 Sep 2025

The biological and immunological significance of the estrogen-related gene IER3 in diabetes

in Systems Endocrinology

Da Ke
Xian He
Wenzhe Li
Hongyan Wu
Yaling Sun
Jie Tan
Ya Wang

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1570332

2,603 views

Original Research

Published on 28 Aug 2025

Elevated total cholesterol in healthy adults mediates the association between impaired thyroid hormone sensitivity and hyperuricemia

in Systems Endocrinology

Xiying Huang
Daojun Yu

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1625843

2,025 views

Review

Published on 27 Aug 2025

Metabolic disturbances in acute pancreatitis: mechanisms and therapeutic implications

in Systems Endocrinology

Chao Fang
Yingwei Ding
Xiaojun Wang
Xusheng Teng

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1579457

4,394 views
1 citation

Original Research

Published on 04 Aug 2025

Mathematical modeling of the interaction between endocrine systems and EEG signals

in Systems Endocrinology

Wei Liu

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1543185

1,993 views

Original Research

Published on 01 Aug 2025

Association between serum anion gap trajectory and mortality in hospitalized patients with sepsis: an analysis of the MIMIC-IV database

in Systems Endocrinology

Lijuan Jing
Xiaopeng Shi
Lijun Xu
Xiangmei Zhao
Faliang Li
Lijie Qin

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1578078

3,665 views
1 citation

Original Research

Published on 30 Jul 2025

Network analysis of cognitive function, glycemic–lipid profiles, and hepatic–renal function in individuals with diverse drinking patterns

in Systems Endocrinology

Shuqi Xu
Ranran Zhao
Jincheng Wang
Xue Yang
Lan Wang
Cuixia An
Xueyi Wang
Ran Wang

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1553691

1,494 views

Original Research

Published on 30 Jul 2025

Association between serum glucose potassium ratio and short- and long-term all-cause mortality in patients with sepsis admitted to the intensive care unit: a retrospective analysis based on the MIMIC-IV database

in Systems Endocrinology

Jiaqi Lou
Ziyi Xiang
Xiaoyu Zhu
Jingyao Song
Shengyong Cui
Jiliang Li
Guoying Jin
Neng Huang
Youfen Fan
Sida Xu

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1555082

3,568 views
5 citations

Original Research

Published on 29 Jul 2025

Independent and combined associations of high-density lipoprotein cholesterol-modified triglyceride-glucose index with all-cause and cardiovascular mortality in patients with acute decompensated heart failure

in Systems Endocrinology

Shiming He
Lin Xie
Guobo Xie
Guoan Jian
Kun Jiang
Zihao Lu
Shuhua Zhang
Qun Wang
Hengcheng Lu
Zhiyu Xiong

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1629066

2,512 views
1 citation

Original Research

Published on 24 Jun 2025

Association between metabolic score for insulin resistance and lower limb pain among the elderly: a cross-sectional study

in Systems Endocrinology

Yanfen Hu
Junxia Yu
Zhenjie Xu
Yan Gao
Yang Li
Lingxia Li

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1530067

2,982 views

Original Research

Published on 04 Jun 2025

Association between triglyceride-glucose related indices and at-risk NASH in U.S. adults with NAFLD: results from NHANES 2017-2020

in Systems Endocrinology

Hanchen Ma
Wenjie Zhang
Zheng Zhao
Shuaichen Jin
Linchuan Li
Ruizhao Zong
Wuyang Li
Ziwei Zhang
Shichang Cui
Yunmiao Pan

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1604991

6,438 views
2 citations

Original Research

Published on 04 Jun 2025

The serum uric acid to apolipoprotein A1 ratio is independently correlated with metabolic dysfunction-associated steatotic liver disease in type 2 diabetes mellitus: findings from a single national metabolic management center cohort

in Systems Endocrinology

Xiu Li Guo
Mei Tu
Xiu Ping Qiu
Wei Wang

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1619003

2,667 views

Original Research

Published on 02 Jun 2025

Nonlinear relationship between lumbar bone mineral density and high-density lipoprotein cholesterol in patients with type 2 diabetes

in Systems Endocrinology

Yu-Hua He
Shi-Li Gu
Yang-Yang Chen
Ming-Mei Xue
Su-Juan Liu
Fang-Fang Guo
Chang-Hua Liang

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1570841

2,314 views
1 citation

Original Research

Published on 30 May 2025

Association between systemic inflammatory indicators on admission and mortality in critically ill patients with diabetic kidney disease based on the MIMIC-IV database: a cohort study

in Systems Endocrinology

Guo-Yin Shen
Qian-Qian Wang
Si-Ang Lv
Zhuo-Deng Huang
Ru-Lin Zhang
Jun Wu

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1503667

3,798 views
2 citations

Original Research

Published on 29 May 2025

Systems metabolic insights into kaempferol-mediated alleviation of alcoholic fatty liver disease

in Systems Endocrinology

Chenmeng Song
Lijia Li
Jia Li
Jengyuan Yao

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1610613

3,195 views
2 citations

Editorial

Published on 27 May 2025

Editorial: Genetics and multi-omics approach in metabolic liver disorders

in Systems Endocrinology

Omar Ramos-Lopez
Prabu Paramasivam
Gautam K. Pandey
Sathishkumar Chandrakumar

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1620522

1,764 views

Original Research

Published on 27 May 2025

Muscle quality index and hyperuricemia: adipose tissue as a mediator

in Systems Endocrinology

Ya Shao
Yu Wang
Xuelian Jiang
Meiling Shao
Bin Liu
Longti Li
Huiqin Zhong

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1562837

3,473 views
1 citation

Original Research

Published on 19 May 2025

Triglyceride-glucose index and periodontitis: evidence from two population-based surveys

in Systems Endocrinology

Jing Huang
Dan Zhang
Hua Li
Yiyun Zhang
Tianxue Long
Xiaojing Guo
Hangyu Cui
Zixuan Wei
Jun Zhao
Mingzi Li

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1558692

5,557 views

Original Research

Published on 13 May 2025

The association between the cardiometabolic index and hyperuricemia: 2011–2016 NHANES

in Systems Endocrinology

Yishan Zhou
Yihong Zou
Yuyu Cao
Yang Gao
Ying Pi
Xiaona Tang
Yang Liu
Yanghong Zhong

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1545968

3,410 views
6 citations

Original Research

Published on 12 May 2025

Bioinformatics analysis combined with experimental validation reveals the novel mechanisms of multi-targets of dapagliflozin attenuating diabetic liver injury

in Systems Endocrinology

Pengyu Wang
Zhen Sun
Qing Lan
Shuo Zhang
Yan Song
Leiming Yang
Mi Chen
Jianfen Shen
Qi Huang
Youzhi Zhang

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1519153

4,176 views
2 citations

Original Research

Published on 06 May 2025

Dissecting the bidirectional associations between the progression of gastrointestinal and endocrine diseases

in Systems Endocrinology

Hongyan Liu
Shucheng Si
Hua Zhang
Siyan Zhan

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1538603

2,798 views

Original Research

Published on 06 May 2025

Association between exposure to terpene compounds and risk of metabolic syndrome: exploring the potential mediating role of inflammatory response

in Systems Endocrinology

Jiyu Nie
Zhizhuo Huang
Lin Wen
Haiying Li
Qianqian Xie
Houchun Wang
Zhengtian Lai
Chuhang Lin
Chunxia Jing

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1551784

3,434 views

Original Research

Published on 30 Apr 2025

Association between dyslipidemia and vitamin D deficiency: a cross-sectional study in Chinese healthy population

in Systems Endocrinology

Bin Li
Jianhong Wang
Jialie Xu
Jianying Xie
Quanyong Liu
Chenxi Yang
Zhengmao Zhang

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1450924

3,149 views
1 citation

443 articles

articles

Metabolic and genetic mechanisms of metabolic dysfunction-associated steatotic liver disease: an integrative perspective from molecular pathways to clinical challenges

Correction: Triglyceride-glucose index and periodontitis: evidence from two population-based surveys

The biological and immunological significance of the estrogen-related gene IER3 in diabetes

Elevated total cholesterol in healthy adults mediates the association between impaired thyroid hormone sensitivity and hyperuricemia

Metabolic disturbances in acute pancreatitis: mechanisms and therapeutic implications

Mathematical modeling of the interaction between endocrine systems and EEG signals

Association between serum anion gap trajectory and mortality in hospitalized patients with sepsis: an analysis of the MIMIC-IV database

Network analysis of cognitive function, glycemic–lipid profiles, and hepatic–renal function in individuals with diverse drinking patterns

Association between serum glucose potassium ratio and short- and long-term all-cause mortality in patients with sepsis admitted to the intensive care unit: a retrospective analysis based on the MIMIC-IV database

Independent and combined associations of high-density lipoprotein cholesterol-modified triglyceride-glucose index with all-cause and cardiovascular mortality in patients with acute decompensated heart failure

Association between metabolic score for insulin resistance and lower limb pain among the elderly: a cross-sectional study

Association between triglyceride-glucose related indices and at-risk NASH in U.S. adults with NAFLD: results from NHANES 2017-2020

The serum uric acid to apolipoprotein A1 ratio is independently correlated with metabolic dysfunction-associated steatotic liver disease in type 2 diabetes mellitus: findings from a single national metabolic management center cohort

Nonlinear relationship between lumbar bone mineral density and high-density lipoprotein cholesterol in patients with type 2 diabetes

Association between systemic inflammatory indicators on admission and mortality in critically ill patients with diabetic kidney disease based on the MIMIC-IV database: a cohort study

Systems metabolic insights into kaempferol-mediated alleviation of alcoholic fatty liver disease

Editorial: Genetics and multi-omics approach in metabolic liver disorders

Muscle quality index and hyperuricemia: adipose tissue as a mediator

Triglyceride-glucose index and periodontitis: evidence from two population-based surveys

The association between the cardiometabolic index and hyperuricemia: 2011–2016 NHANES

Bioinformatics analysis combined with experimental validation reveals the novel mechanisms of multi-targets of dapagliflozin attenuating diabetic liver injury

Dissecting the bidirectional associations between the progression of gastrointestinal and endocrine diseases

Association between exposure to terpene compounds and risk of metabolic syndrome: exploring the potential mediating role of inflammatory response

Association between dyslipidemia and vitamin D deficiency: a cross-sectional study in Chinese healthy population