Frontiers in Endocrinology | Systems Endocrinology

Original Research

Published on 01 Aug 2025

Association between serum anion gap trajectory and mortality in hospitalized patients with sepsis: an analysis of the MIMIC-IV database

in Systems Endocrinology

Lijuan Jing
Xiaopeng Shi
Lijun Xu
Xiangmei Zhao
Faliang Li
Lijie Qin

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1578078

331 views

Original Research

Published on 30 Jul 2025

Network analysis of cognitive function, glycemic–lipid profiles, and hepatic–renal function in individuals with diverse drinking patterns

in Systems Endocrinology

Shuqi Xu
Ranran Zhao
Jincheng Wang
Xue Yang
Lan Wang
Cuixia An
Xueyi Wang
Ran Wang

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1553691

326 views

Original Research

Published on 30 Jul 2025

Association between serum glucose potassium ratio and short- and long-term all-cause mortality in patients with sepsis admitted to the intensive care unit: a retrospective analysis based on the MIMIC-IV database

in Systems Endocrinology

Jiaqi Lou
Ziyi Xiang
Xiaoyu Zhu
Jingyao Song
Shengyong Cui
Jiliang Li
Guoying Jin
Neng Huang
Youfen Fan
Sida Xu

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1555082

297 views

Original Research

Published on 29 Jul 2025

Independent and combined associations of high-density lipoprotein cholesterol-modified triglyceride-glucose index with all-cause and cardiovascular mortality in patients with acute decompensated heart failure

in Systems Endocrinology

Shiming He
Lin Xie
Guobo Xie
Guoan Jian
Kun Jiang
Zihao Lu
Shuhua Zhang
Qun Wang
Hengcheng Lu
Zhiyu Xiong

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1629066

438 views

Review

Accepted on 24 Jul 2025

Metabolic Disturbances in Acute Pancreatitis: Mechanisms and Therapeutic Implications

in Systems Endocrinology

Fang Chao
Yingwei Ding
Xiaojun Wang
Xusheng Teng

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1579457

232 views

Original Research

Published on 24 Jun 2025

Association between metabolic score for insulin resistance and lower limb pain among the elderly: a cross-sectional study

in Systems Endocrinology

Yanfen Hu
Junxia Yu
Zhenjie Xu
Yan Gao
Yang Li
Lingxia Li

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1530067

1,131 views

Original Research

Published on 04 Jun 2025

Association between triglyceride-glucose related indices and at-risk NASH in U.S. adults with NAFLD: results from NHANES 2017-2020

in Systems Endocrinology

Hanchen Ma
Wenjie Zhang
Zheng Zhao
Shuaichen Jin
Linchuan Li
Ruizhao Zong
Wuyang Li
Ziwei Zhang
Shichang Cui
Yunmiao Pan

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1604991

2,849 views

Original Research

Published on 04 Jun 2025

The serum uric acid to apolipoprotein A1 ratio is independently correlated with metabolic dysfunction-associated steatotic liver disease in type 2 diabetes mellitus: findings from a single national metabolic management center cohort

in Systems Endocrinology

Xiu Li Guo
Mei Tu
Xiu Ping Qiu
Wei Wang

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1619003

1,276 views

Original Research

Published on 02 Jun 2025

Nonlinear relationship between lumbar bone mineral density and high-density lipoprotein cholesterol in patients with type 2 diabetes

in Systems Endocrinology

Yu-Hua He
Shi-Li Gu
Yang-Yang Chen
Ming-Mei Xue
Su-Juan Liu
Fang-Fang Guo
Chang-Hua Liang

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1570841

1,145 views

Original Research

Published on 30 May 2025

Association between systemic inflammatory indicators on admission and mortality in critically ill patients with diabetic kidney disease based on the MIMIC-IV database: a cohort study

in Systems Endocrinology

Guo-Yin Shen
Qian-Qian Wang
Si-Ang Lv
Zhuo-Deng Huang
Ru-Lin Zhang
Jun Wu

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1503667

1,668 views

Original Research

Published on 29 May 2025

Systems metabolic insights into kaempferol-mediated alleviation of alcoholic fatty liver disease

in Systems Endocrinology

Chenmeng Song
Lijia Li
Jia Li
Jengyuan Yao

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1610613

1,300 views

Editorial

Published on 27 May 2025

Editorial: Genetics and multi-omics approach in metabolic liver disorders

in Systems Endocrinology

Omar Ramos-Lopez
Prabu Paramasivam
Gautam K. Pandey
Sathishkumar Chandrakumar

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1620522

867 views

Original Research

Published on 27 May 2025

Muscle quality index and hyperuricemia: adipose tissue as a mediator

in Systems Endocrinology

Ya Shao
Yu Wang
Xuelian Jiang
Meiling Shao
Bin Liu
Longti Li
Huiqin Zhong

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1562837

1,506 views

Original Research

Published on 19 May 2025

Triglyceride-glucose index and periodontitis: evidence from two population-based surveys

in Systems Endocrinology

Jing Huang
Dan Zhang
Hua Li
Yiyun Zhang
Tianxue Long
Xiaojing Guo
Hangyu Cui
Zixuan Wei
Jun Zhao
Mingzi Li

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1558692

2,250 views

Original Research

Published on 13 May 2025

The association between the cardiometabolic index and hyperuricemia: 2011–2016 NHANES

in Systems Endocrinology

Yishan Zhou
Yihong Zou
Yuyu Cao
Yang Gao
Ying Pi
Xiaona Tang
Yang Liu
Yanghong Zhong

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1545968

1,694 views

Original Research

Published on 12 May 2025

Bioinformatics analysis combined with experimental validation reveals the novel mechanisms of multi-targets of dapagliflozin attenuating diabetic liver injury

in Systems Endocrinology

Pengyu Wang
Zhen Sun
Qing Lan
Shuo Zhang
Yan Song
Leiming Yang
Mi Chen
Jianfen Shen
Qi Huang
Youzhi Zhang

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1519153

1,925 views