Frontiers in Immunology | Cytokines and Soluble Mediators in Immunity

Review

Published on 07 Oct 2025

The innate immune response in SARS-CoV2 infection: focus on toll-like receptor 4 in severe disease outcomes

in Cytokines and Soluble Mediators in Immunity

Enrico Maggi
Nadine Landolina
Francesca Romana Mariotti
Enrico Munari
Nicola Tumino
Paola Vacca
Bruno Azzarone
Lorenzo Moretta

Frontiers in Immunology

doi 10.3389/fimmu.2025.1658396

2,089 views

Original Research

Published on 06 Oct 2025

IL-7 promotes the formation of DNA double strand breaks and DNA repair in murine pro-B cells

in Cytokines and Soluble Mediators in Immunity

Alessia Lamolinara
Chiara Di Lisio
Julie A. Hixon
Pasquale Simeone
Antonella De Cola
Maria D. Falco
Thomas J. Meyer
Alessio Ferrone
Domenico Genovesi
Paola Lanuti

Frontiers in Immunology

doi 10.3389/fimmu.2025.1633892

2,554 views

Original Research

Published on 02 Oct 2025

Integrative genetic and multi-omics analysis reveals the interleukin-6 receptor’s role in recurrent spontaneous abortion

in Cytokines and Soluble Mediators in Immunity

Weixu Ma
Zhongjia Gu
Qiwang Lin
Mingzhu Cao
Junmin Zhong
Xin Li
Hongyan Li
Yue Lin
Han Lin
Mengchang Xu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1659251

2,122 views

Review

Published on 02 Oct 2025

Chemokines as key mediators in RIPI: pathophysiology and translational potential

in Cytokines and Soluble Mediators in Immunity

Ling Zhao
Lihua Dong
Xue Hou
Weijia Fu
Jiaying Wei
Wentong Liu
Wei Hou

Frontiers in Immunology

doi 10.3389/fimmu.2025.1607447

2,624 views

Original Research

Published on 01 Oct 2025

IL-19 suppresses Hippo signaling via modulating YAP1 phosphorylation in osteoarthritis

in Cytokines and Soluble Mediators in Immunity

Jiezhong Deng
Jun Gu
Xiaoshan Gong
Hao Tang
Yuyi Cai
Yusheng Yang
Shiwu Dong
Chunrong Zhao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1630253

2,373 views

Case Report

Published on 01 Oct 2025

Case Report: Longitudinal mass cytometry profiling of a patient with disseminated histoplasmosis and secondary hemophagocytic lymphohistiocytosis

in Cytokines and Soluble Mediators in Immunity

Jiaying Zhang
Longyu Zhang
Zixin Kang
Danlei Mou
Lianchun Liang
Yu Chen
Yingmei Feng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1660382

1,800 views

Review

Published on 23 Sep 2025

Chemokines as potential biomarkers for predicting the course of COVID-19 – a review of the literature

in Cytokines and Soluble Mediators in Immunity

Blanka Wolszczak-Biedrzycka
Beata Cieślikiewicz
Filip Studniarz
Łukasz Dąbrowski
Mateusz Fąs
Krystyna Matyszkiewicz–Suchodolska
Monika Harasimowicz
Justyna Dorf

Frontiers in Immunology

doi 10.3389/fimmu.2025.1662643

3,005 views

Original Research

Published on 22 Sep 2025

Extracellular vesicles of patients with acute-on-chronic liver failure induce mitochondrial dysfunction in T cells

in Cytokines and Soluble Mediators in Immunity

Mona-May Langer
Sabrina Guckenbiehl
Alina Bauschen
Helena Stadler
Farnusch Kaschani
Markus Kaiser
Bernd Walkenfort
Heiner Wedemeyer
Christian M. Lange

Frontiers in Immunology

doi 10.3389/fimmu.2025.1656692

2,629 views

Review

Published on 19 Sep 2025

CCR10: a comprehensive review of its function, phylogeny, role in immune cell trafficking and disease pathogenesis

in Cytokines and Soluble Mediators in Immunity

Amanda Lopes Willuveit
Ana Carolina Buzzo Stefanini
Taís Matozo
Luciana Cavalheiro Marti

Frontiers in Immunology

doi 10.3389/fimmu.2025.1599277

2,690 views

Original Research

Published on 18 Sep 2025

Therapy of 4T1 breast cancer in mice with Vaccinia virus encoding tumor-associated antigen epitopes and mouse IL2 cytokine

in Cytokines and Soluble Mediators in Immunity

Mingyu Ye
Ivan Petrov
Ivaylo Gentschev
Eman M. Othman
Aladar A. Szalay

Frontiers in Immunology

doi 10.3389/fimmu.2025.1636256

2,857 views

Original Research

Published on 12 Sep 2025

Longitudinal evaluation of T-cell responses to Pfizer-BioNTech and Janssen SARS-CoV-2 vaccines as boosters in Ghanaian adults

in Cytokines and Soluble Mediators in Immunity

Frank Osei
Kekeli Korshi Tudzi
Isaac Otieno Othol
Selorm Philip Segbefia
Diana Ahu Prah
Evans Nii Armah-Vedjesu
Abigail Naa Adjorkor Pobee
Oscar Nii Otto Darko
Theophilus Brenko
Doreen Teye-Adjei

Frontiers in Immunology

doi 10.3389/fimmu.2025.1643083

2,910 views

Original Research

Published on 12 Sep 2025

Low rather than high interleukin-6 levels are associated with immune-related adverse events in cancer patients treated with immune checkpoint inhibitors

in Cytokines and Soluble Mediators in Immunity

Iñigo Les
David de Haedo
Mireia Martínez
Berta Ibáñez-Beroiz
Amaia Moreno
Ibone de Elejoste
Ana Campillo-Calatayud
Inés Pérez-Francisco
María Cabero
Iñaki Elejalde

Frontiers in Immunology

doi 10.3389/fimmu.2025.1677778

1,875 views

Review

Published on 12 Sep 2025

Research progress on the mechanisms of interleukin and chemokine families in driving calcium oxalate nephrolithiasis formation

in Cytokines and Soluble Mediators in Immunity

Fujie Liang
Fuyou Guo
Runjun Liu
Xiang Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1651003

2,926 views

Review

Published on 10 Sep 2025

Role of depression-mediated alterations in pro-inflammatory cytokines in carcinogenesis

in Cytokines and Soluble Mediators in Immunity

Rui Cao
Heguo Jiang
Ping Chen
Chunhua Dai

Frontiers in Immunology

doi 10.3389/fimmu.2025.1659153

3,447 views

Original Research

Published on 05 Sep 2025

Inhibition of IL-27 signaling regulates chemokine levels and sustains CXCR2 receptor expression on mononuclear cells to improve disease outcomes during gram-negative neonatal sepsis

in Cytokines and Soluble Mediators in Immunity

Madhavi Annamanedi
Jordan K. Vance
Cory M. Robinson

Frontiers in Immunology

doi 10.3389/fimmu.2025.1653355

2,360 views
1 citation

Review

Published on 05 Sep 2025

The interplay between mesenchymal stem cells and the immune microenvironment in rotator cuff tendon-to-bone healing: current progress and future directions

in Cytokines and Soluble Mediators in Immunity

Dong Li
Yujia Zou
Yuanting Zhao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1661340

3,122 views
1 citation

Mini Review

Published on 04 Sep 2025

Mini review: Interleukin-32 as a key mediator of type 1 diabetes pathogenesis

in Cytokines and Soluble Mediators in Immunity

James A. Pearson
Stephanie J. Hanna

Frontiers in Immunology

doi 10.3389/fimmu.2025.1641698

1,852 views
1 citation

Review

Published on 03 Sep 2025

Decoding STAT3: a new frontier in understanding and treating hyperoxic lung injury

in Cytokines and Soluble Mediators in Immunity

Wulan Li
Qian Liu
Wenyan Xiong
Xu Zhong
Lei Tian

Frontiers in Immunology

doi 10.3389/fimmu.2025.1657823

2,263 views

Original Research

Published on 03 Sep 2025

Mechanism of IFITM1 regulating epidural scar hyperplasia after laminectomy through SMAD3/CBR4 pathway

in Cytokines and Soluble Mediators in Immunity

Haoran Wang
Zekai Zhu
Jun Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1628970

1,897 views

Original Research

Published on 01 Sep 2025

NUPA10hd-immortalized and genetically engineered progenitors allow studying dendritic cell immune functions

in Cytokines and Soluble Mediators in Immunity

Guerric P. B. Samson
Nadine Anslinger
Daniel F. Legler
Daniela Finke

Frontiers in Immunology

doi 10.3389/fimmu.2025.1658429

2,857 views

Review

Published on 26 Aug 2025

Inflammation-associated drug resistance and tumor growth in TNBC

in Cytokines and Soluble Mediators in Immunity

Arij Fouzat Hassan
Hadeel Kheraldine
Lama Abujamous
Hamda Al-Thawadi
Abdelbary Elhissi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1623137

3,371 views

Original Research

Published on 22 Aug 2025

Combination of αCD4 antibody and retinal antigen injection induces long-term disease control in autoimmune uveitis

in Cytokines and Soluble Mediators in Immunity

Dijie Qiao
Lu Zhang
Yajie Zhong
Dongmei Liu
Zilin Chen
Wai Po Chong
Jun Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1636901

2,260 views

Review

Published on 22 Aug 2025

Leukocyte recruitment in flavivirus-induced encephalitis

in Cytokines and Soluble Mediators in Immunity

Emily Slowikowski
Céleste Willems
Pedro Elias Marques

Frontiers in Immunology

doi 10.3389/fimmu.2025.1650903

1,725 views

Editorial

Published on 21 Aug 2025

Editorial: Interactions between autophagy and immune response: cell communication and disease implications

in Cytokines and Soluble Mediators in Immunity

Gustavo J. S. Pereira
Veronica Bordoni
Manuela Antonioli

Frontiers in Immunology

doi 10.3389/fimmu.2025.1676537

1,390 views

1,282 articles

articles

The innate immune response in SARS-CoV2 infection: focus on toll-like receptor 4 in severe disease outcomes

IL-7 promotes the formation of DNA double strand breaks and DNA repair in murine pro-B cells

Integrative genetic and multi-omics analysis reveals the interleukin-6 receptor’s role in recurrent spontaneous abortion

Chemokines as key mediators in RIPI: pathophysiology and translational potential

IL-19 suppresses Hippo signaling via modulating YAP1 phosphorylation in osteoarthritis

Case Report: Longitudinal mass cytometry profiling of a patient with disseminated histoplasmosis and secondary hemophagocytic lymphohistiocytosis

Chemokines as potential biomarkers for predicting the course of COVID-19 – a review of the literature

Extracellular vesicles of patients with acute-on-chronic liver failure induce mitochondrial dysfunction in T cells

CCR10: a comprehensive review of its function, phylogeny, role in immune cell trafficking and disease pathogenesis

Therapy of 4T1 breast cancer in mice with Vaccinia virus encoding tumor-associated antigen epitopes and mouse IL2 cytokine

Longitudinal evaluation of T-cell responses to Pfizer-BioNTech and Janssen SARS-CoV-2 vaccines as boosters in Ghanaian adults

Low rather than high interleukin-6 levels are associated with immune-related adverse events in cancer patients treated with immune checkpoint inhibitors

Research progress on the mechanisms of interleukin and chemokine families in driving calcium oxalate nephrolithiasis formation

Role of depression-mediated alterations in pro-inflammatory cytokines in carcinogenesis

Inhibition of IL-27 signaling regulates chemokine levels and sustains CXCR2 receptor expression on mononuclear cells to improve disease outcomes during gram-negative neonatal sepsis

The interplay between mesenchymal stem cells and the immune microenvironment in rotator cuff tendon-to-bone healing: current progress and future directions

Mini review: Interleukin-32 as a key mediator of type 1 diabetes pathogenesis

Decoding STAT3: a new frontier in understanding and treating hyperoxic lung injury

Mechanism of IFITM1 regulating epidural scar hyperplasia after laminectomy through SMAD3/CBR4 pathway

NUPA10hd-immortalized and genetically engineered progenitors allow studying dendritic cell immune functions

Inflammation-associated drug resistance and tumor growth in TNBC

Combination of αCD4 antibody and retinal antigen injection induces long-term disease control in autoimmune uveitis

Leukocyte recruitment in flavivirus-induced encephalitis

Editorial: Interactions between autophagy and immune response: cell communication and disease implications