Frontiers in Immunology

Original Research

Published on 30 Jun 2025

Bone marrow mesenchymal stem cell-derived exosomes alleviate DSS-induced inflammatory bowel disease in mice through inhibiting intestinal epithelial cell pyroptosis via delivery of TSG-6

in Inflammation

Bihua Wu
Shuangyan Su
Xianyu Wang
Yuwei Li
Zhenghao Mei
Fenglin Lou
Le Guo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1601591

4,867 views
2 citations

Original Research

Published on 30 Jun 2025

LncRNA NEAT1 promotes epithelial–mesenchymal transition in nasal polyp cells via the miR-199-3p/PAK4 axis

in Inflammation

Shuman Li
Yu Jiang
Yalan Zhang
Bowen Zheng
Chao Yuan
Yang Shen
Yi Zhao
Tao Lu
Yucheng Yang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1613179

4,373 views

Review

Published on 30 Jun 2025

Mitochondrial unfolded protein response in regulatory T cell function: a protective mechanism in immune aging

in Inflammation

Lillie Lewis
Deepa Valvi
Roberto Gedaly
Francesc Marti

Frontiers in Immunology

doi 10.3389/fimmu.2025.1621759

4,914 views
2 citations

Review

Published on 27 Jun 2025

Intestinal injury signaling pathway in sepsis

in Inflammation

Lin Liu
Qin Yue
Jinhao Chen
Hui Liu
Xinyi Zeng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1620965

5,099 views
4 citations

Original Research

Published on 27 Jun 2025

The role of ATF3 in precision medicine of brain arteriovenous malformation: based on endothelial cell proliferation

in Inflammation

Jiwei Ma
Lei Meng
Jiyu Ji
Xiangyang Wang
Nan Wu
Lei Sun
Shupeng Zhao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1567970

2,993 views

Mini Review

Published on 27 Jun 2025

Histone variants: key regulators of inflammation in cell dedifferentiation and transdifferentiation

in Inflammation

Manlio Vinciguerra
Desislava K. Tsoneva

Frontiers in Immunology

doi 10.3389/fimmu.2025.1619100

2,906 views
3 citations

Review

Published on 27 Jun 2025

A new insight: crosstalk between neutrophil extracellular traps and the gut-liver axis for nonalcoholic fatty liver disease

in Inflammation

Jinping Yin
Yanli Zhu
Rongrong Liu
Weixin Wang
Zhicheng Wang
Jianfeng Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1599956

5,461 views
1 citation

Editorial

Published on 27 Jun 2025

Editorial: Exploring cardiovascular and cerebrovascular diseases interaction with inflammation: biomarkers, drug targets, and personalized treatments through multi-omics data integration

in Inflammation

Qikai Tang
Chenfeng Ma
Yacheng Shi
Jian Song
Yong Cao
Wei Wu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1619519

1,625 views

Editorial

Published on 27 Jun 2025

Editorial: Community series in targeting signalling pathways in inflammatory diseases, volume II

in Inflammation

Mirza S. Baig
Faaiza Siddiqi
Rajat Atre
Suraj P. Parihar
Syed Faisal
Uzma Saqib

Frontiers in Immunology

doi 10.3389/fimmu.2025.1639004

1,469 views

Review

Published on 27 Jun 2025

TGF-β inhibitors: the future for prevention and treatment of liver fibrosis?

in Inflammation

Weili Wang
Yilin Gao
Yizhen Chen
Meng Cheng
Yonghao Sang
Liuting Wei
Rong Dai
Yiping Wang
Lei Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1583616

8,271 views
8 citations

Original Research

Published on 27 Jun 2025

Exercise improves pulmonary fibrosis and neurological symptoms via S100A12 inhibition

in Inflammation

Yan Sun
Meng Li
Jingmin Yuan
Wenrui Li
Hongli Quan
Yan Li
Zhenjing Kang
Hao Cheng
Hui Ren
Mingwei Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1583827

4,099 views

Original Research

Published on 26 Jun 2025

FTO O-GlcNAcylation promotes TRIM21-mediated FTO ubiquitination degradation to sustain the negative feedback control of macrophage inflammation

in Inflammation

Lu Zhang
Min Liu
Yan Xie
Bi-Feng Yuan
Zhiyong Peng
Jun Xiong
Xiao-Lian Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1593243

5,035 views
3 citations

Brief Research Report

Published on 26 Jun 2025

Efficacy and safety of ruxolitinib in adult patients with refractory rheumatic disease-associated macrophage activation syndrome

in Inflammation

Jingjing Li
Ran Wang
Jie Chen
Antao Xu
Yakai Fu
Yanwei Lin
Xiaodong Wang
Shuang Ye
Ye Yuan
Fang Du

Frontiers in Immunology

doi 10.3389/fimmu.2025.1604648

3,071 views
2 citations

Original Research

Published on 25 Jun 2025

Single-cell transcriptome and multi-omics integration reveal ferroptosis-driven immune microenvironment remodeling in knee osteoarthritis

in Inflammation

Yushun Wu
Jing Liu
Wenying Yu
Xiaoding Wang
Jian Li
Weiquan Zeng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1608378

8,501 views
6 citations

Original Research

Published on 25 Jun 2025

Organ of Corti macrophages: a distinct group of cochlear macrophages with potential roles in supporting cell degeneration and survival

in Inflammation

Mengxiao Ye
Celia Zhang
Dalian Ding
Guang-Di Chen
Henry J. Adler
Rania Sharaf
Bo Hua Hu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1617146

3,172 views
1 citation

Review

Published on 25 Jun 2025

TREM2 in MASH: integrating lipid metabolism and immune response

in Inflammation

Shuyi Shi
Yangyang Zhou
Haiming Zhang
Junli Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1604837

6,516 views
6 citations

Original Research

Published on 23 Jun 2025

Altered co-expression patterns of synovial fluid proteins related to the immune system and extracellular matrix organization in late stage OA, compared to non-OA controls

in Inflammation

Jenny Lönsjö
Martin Rydén
Aleksandra Turkiewicz
Velocity Hughes
Jon Tjörnstand
Patrik Önnerfjord
Martin Englund
Neserin Ali

Frontiers in Immunology

doi 10.3389/fimmu.2025.1523103

2,551 views

Original Research

Published on 23 Jun 2025

Short-term heavy drinking in a non-human primate model skews monocytes toward a hypo-inflammatory phenotype

in Inflammation

Madison B. Blanton
Hami Hemati
Qi Qiao
Rupak Khadka
Gregory Hawk
Kathleen A. Grant
Ilhem Messaoudi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1606092

3,532 views
1 citation

Correction

Published on 23 Jun 2025

Correction: Protein carbamylation in atherosclerotic plaques correlates with uremia and disease progression, localizing predominantly to foam cells

in Inflammation

Valeria Saar-Kovrov
Aleksandra Pawlowska
Adrien Guillot
Marion J. J. Gijbels
Judith C. Sluimer
Lieve Temmerman
Pieter Goossens
Barend M. E. Mees
Frank Tacke
Vera Jankowski

Frontiers in Immunology

doi 10.3389/fimmu.2025.1637511

1,505 views

Original Research

Published on 23 Jun 2025

Serum exosomal microRNA profiling reveals a down-regulation of hsa-miR-124-3p in patients with severe acne

in Inflammation

Shujuan Zhang
Yimin Liang
Manqi Xia
Xin Tian
Ziyan Chen
Ling Lin
Jingyao Liang
Yumei Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1554811

2,838 views
1 citation

Original Research

Published on 19 Jun 2025

Predicting biomarkers of progressive pulmonary fibrosis: morphological, cytokine profile, and clinical portrait

in Inflammation

Nicol Bernardinello
Federica Pezzuto
Lauren D’Sa
Luca Vedovelli
Chiara Giraudo
Anamaria Chelu
Cecilia de Chellis
Francesca Lunardi
Francesco Fortarezza
Francesca Boscaro

Frontiers in Immunology

doi 10.3389/fimmu.2025.1514439

4,400 views
1 citation

Original Research

Published on 19 Jun 2025

Hs-CRP/HDL-C ratio as a predictive inflammatory-lipid marker for sarcopenia: evidence from NHANES 2015–2018

in Inflammation

Xin-Yan Guo
Liang-Wen Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1600421

5,883 views
6 citations

Original Research

Published on 19 Jun 2025

The fibrin-derived peptide FX06 protects human pulmonary endothelial cells against the COVID-19-triggered cytokine storm

in Inflammation

Zhiran Wang
Dmitrii Lebedev
Simeng Li
Sudharshan Rao
Kevin Wu
Lorcan Doyle
Kieran Wynne
Alfonso Blanco
Margaritha M. Mysior
Jeremy C. Simpson

Frontiers in Immunology

doi 10.3389/fimmu.2025.1591860

3,619 views

Mini Review

Published on 19 Jun 2025

A systems immunology perspective on gout pathogenesis and its precision-targeted treatment strategies

in Inflammation

Zilong Chen
Qian Guo
Yanzhao Zhang
Lulu Chen
Puyu Li
Wenfei Cheng
Chuanxin Liu
Hongwei Jiang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1615914

7,360 views
3 citations

5,790 articles

articles

Bone marrow mesenchymal stem cell-derived exosomes alleviate DSS-induced inflammatory bowel disease in mice through inhibiting intestinal epithelial cell pyroptosis via delivery of TSG-6

LncRNA NEAT1 promotes epithelial–mesenchymal transition in nasal polyp cells via the miR-199-3p/PAK4 axis

Mitochondrial unfolded protein response in regulatory T cell function: a protective mechanism in immune aging

Intestinal injury signaling pathway in sepsis

The role of ATF3 in precision medicine of brain arteriovenous malformation: based on endothelial cell proliferation

Histone variants: key regulators of inflammation in cell dedifferentiation and transdifferentiation

A new insight: crosstalk between neutrophil extracellular traps and the gut-liver axis for nonalcoholic fatty liver disease

Editorial: Exploring cardiovascular and cerebrovascular diseases interaction with inflammation: biomarkers, drug targets, and personalized treatments through multi-omics data integration

Editorial: Community series in targeting signalling pathways in inflammatory diseases, volume II

TGF-β inhibitors: the future for prevention and treatment of liver fibrosis?

Exercise improves pulmonary fibrosis and neurological symptoms via S100A12 inhibition

FTO O-GlcNAcylation promotes TRIM21-mediated FTO ubiquitination degradation to sustain the negative feedback control of macrophage inflammation

Efficacy and safety of ruxolitinib in adult patients with refractory rheumatic disease-associated macrophage activation syndrome

Single-cell transcriptome and multi-omics integration reveal ferroptosis-driven immune microenvironment remodeling in knee osteoarthritis

Organ of Corti macrophages: a distinct group of cochlear macrophages with potential roles in supporting cell degeneration and survival

TREM2 in MASH: integrating lipid metabolism and immune response

Altered co-expression patterns of synovial fluid proteins related to the immune system and extracellular matrix organization in late stage OA, compared to non-OA controls

Short-term heavy drinking in a non-human primate model skews monocytes toward a hypo-inflammatory phenotype

Correction: Protein carbamylation in atherosclerotic plaques correlates with uremia and disease progression, localizing predominantly to foam cells

Serum exosomal microRNA profiling reveals a down-regulation of hsa-miR-124-3p in patients with severe acne

Predicting biomarkers of progressive pulmonary fibrosis: morphological, cytokine profile, and clinical portrait

Hs-CRP/HDL-C ratio as a predictive inflammatory-lipid marker for sarcopenia: evidence from NHANES 2015–2018

The fibrin-derived peptide FX06 protects human pulmonary endothelial cells against the COVID-19-triggered cytokine storm

A systems immunology perspective on gout pathogenesis and its precision-targeted treatment strategies