Frontiers in Immunology | Multiple Sclerosis and Neuroimmunology

Original Research

Published on 02 Jan 2026

Disproportionality analysis of drug-associated progressive multifocal leukoencephalopathy: roles of underlying diseases and immunomodulatory therapies in FAERS

in Multiple Sclerosis and Neuroimmunology

Xiaozhen Lin
Naishen Qin
Baoxia He
Jinhua Chen
Yajuan Zhang
Hui Wang
Weiling Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1707211

1,448 views

Review

Published on 16 Dec 2025

Macrophages as central mediators of sympathetic neuro-immune interplay in autoimmunity

in Multiple Sclerosis and Neuroimmunology

Elke M. Muntjewerff
Vijay S. Josyula
Franziska Lehmair
Gustaf Christoffersson

Frontiers in Immunology

doi 10.3389/fimmu.2025.1654382

2,399 views

Brief Research Report

Published on 12 Dec 2025

Case report of intracranial tumor with serum MOG-IgG positivity

in Multiple Sclerosis and Neuroimmunology

Zhuo Min
Lingru Wang
Yulai Kang
Lili Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1673927

1,002 views

Review

Published on 11 Dec 2025

Brain TRPV1 channel-mediated calcium influx: the immunomodulatory pathway of acupuncture in neuroinflammation

in Multiple Sclerosis and Neuroimmunology

Qingqing Tang
Min He
Peng Zheng
Mengmeng Sun
Jiazhen Cao
Qi Zhang
Jing He
Run Sun
Bing Zhu
Tie Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1700282

1,808 views

Original Research

Published on 11 Dec 2025

Glymphatic dysfunction in neuromyelitis optica spectrum disorder

in Multiple Sclerosis and Neuroimmunology

Ying Zhang
Hongxi Chen
Ziyan Shi
Rui Wang
Xiaofei Wang
Qin Du
Yuntao Mo
Shixiang Chen
Hongyu Zhou

Frontiers in Immunology

doi 10.3389/fimmu.2025.1698986

2,035 views

Original Research

Accepted on 09 Dec 2025

Neuronal autoantibodies associated with poorer neuropsychological and motor outcomes 6 months after stroke: Results from the PHYS-STROKE trial

in Multiple Sclerosis and Neuroimmunology

Charlotte Pietrock
Konrad Neumann
Kristin Rentzsch
Harald Prüss
Andreas Meisel
Matthias Endres
Alexander Heinrich Nave

Frontiers in Immunology

365 views

Original Research

Published on 09 Dec 2025

Brain-infiltrated monocyte macrophages in a rat model of temporal lobe epilepsy: revisiting the pro-inflammatory paradigm

in Multiple Sclerosis and Neuroimmunology

Wanda Grabon
Nadia Gasmi
Anatole Lang
Anne Ruiz
Béatrice Georges
Victor Blot
Michaël Ogier
Sylvain Rheims
Fabrice P Navarro
Laurent Bezin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1695856

1,369 views

Original Research

Published on 08 Dec 2025

Autoimmune cerebellopyramidal syndrome as a complex form of autoimmune cerebellar ataxia: a cohort study

in Multiple Sclerosis and Neuroimmunology

Mange Liu
Haitao Ren
Siyuan Fan
Le Zhang
Hongzhi Guan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1724439

861 views

Systematic Review

Published on 05 Dec 2025

Visualized knowledge mapping on the current research trends and emerging areas of neuroimmune modulation in the past two decades

in Multiple Sclerosis and Neuroimmunology

Xu Han
Yan Zhou
Xiyao Gu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1671578

1,618 views

Opinion

Published on 03 Dec 2025

Beyond the cut-off: harmonizing kappa free light chain index using likelihood ratios improves the clinical interpretation in the diagnosis of multiple sclerosis

in Multiple Sclerosis and Neuroimmunology

Matthijs Oyaert
Louis Nevejan
Cathérine Dekeyser
Pieter De Kesel
Melissa Cambron
Ludo Vanopdenbosch
Liesbeth Van Hijfte
Guy Laureys
Martine Vercammen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1672662

1,028 views

Review

Published on 03 Dec 2025

Dual role of complement in neuronal repair

in Multiple Sclerosis and Neuroimmunology

Agnieszka Lukomska
Peter Ciesielski
Mariusz Z. Ratajczak
Magdalena Kucia

Frontiers in Immunology

doi 10.3389/fimmu.2025.1712452

1,771 views

Original Research

Published on 01 Dec 2025

Reduced CD40 expression in B cell subsets of individuals with radiologically isolated syndrome

in Multiple Sclerosis and Neuroimmunology

Christian W. Keller
Kerstin Stein
Andreu Vilaseca
Luisa M. Villar
Gary Álvarez-Bravo
Maria Protopapa
Josef Shin
Nicolás Fissolo
José Enrique Martínez-Rodríguez
Ana Quiroga-Varela

Frontiers in Immunology

doi 10.3389/fimmu.2025.1680233

1,277 views

Original Research

Published on 21 Nov 2025

Modeling lymphocyte subset dynamics after ublituximab therapy in patients with multiple sclerosis: an Italian prospective study

in Multiple Sclerosis and Neuroimmunology

Aurora Zanghì
Paola Sofia Di Filippo
Massimo Papale
Claudia Rutigliano
Maria Claudia Moretti
Carlo Avolio
Gaetano Corso
Emanuele D’Amico

Frontiers in Immunology

doi 10.3389/fimmu.2025.1688090

1,971 views

Review

Published on 20 Nov 2025

The critical role of Th17 cells and IL-17A in autoimmune and inflammation-associated neurological diseases: mechanisms and therapeutic perspectives

in Multiple Sclerosis and Neuroimmunology

Inmaculada Xu Lou
Huifen Zhou
Haitong Wan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1656422

4,123 views
1 citation

Mini Review

Published on 20 Nov 2025

Neuroimmune modulatory effects of the NLRP3 inflammasome: the role of sex and living environment in brain affecting conditions

in Multiple Sclerosis and Neuroimmunology

Miriam Ciani
Giovanna Rigillo
Beatrice Bertarini
Cristina Benatti
Silvia Alboni
Fabio Tascedda

Frontiers in Immunology

doi 10.3389/fimmu.2025.1711656

2,079 views

Correction

Published on 20 Nov 2025

Correction: Polysialic acid restrains inflammatory monocyte maturation

in Multiple Sclerosis and Neuroimmunology

Ingredy Passos
Benjamin Peschke
Shrey Gandhi
Judith Derdelinckx
Louisa Müller-Miny
Harald Neumann
Jan D. Lünemann
Christian W. Keller

Frontiers in Immunology

doi 10.3389/fimmu.2025.1731973

818 views

Review

Published on 20 Nov 2025

Decoding tRNA dynamics in neuroimmune disorders: mechanistic insights, diagnostic innovations, and therapeutic opportunities

in Multiple Sclerosis and Neuroimmunology

Enlin Liang
Wenya Wang
Li Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1642370

2,043 views

Review

Published on 19 Nov 2025

Vaccination and COVID-19: impact on long-COVID

in Multiple Sclerosis and Neuroimmunology

Gustavo N. Guimarães
Natália S. Brunetti
Dieila G. De Lima
José Luiz Proenca-Modena
Alessandro S. Farias

Frontiers in Immunology

doi 10.3389/fimmu.2025.1686572

3,129 views

Original Research

Published on 19 Nov 2025

Natalizumab and fumarate treatment differentially modulate CD4+ T cell and B cell subtypes in multiple sclerosis patients without impacting durable COVID-19 vaccine responses

in Multiple Sclerosis and Neuroimmunology

Ryan Curtin
Yogambigai Velmurugu
Fatoumatta Dibba
Yuan Hao
Samantha Nyovanie
Andrea Lopez
David Mieles
Courtney Ng
Katherine Perdomo
Nicole Scott

Frontiers in Immunology

doi 10.3389/fimmu.2025.1568157

1,974 views

Original Research

Published on 11 Nov 2025

Genetic knockdown of DYRK1A attenuates cognitive impairment, Aβ pathology, tauopathy and neuroinflammatory responses in mouse models of AD

in Multiple Sclerosis and Neuroimmunology

Hyun-ju Lee
Sora Kang
Yoo Jin Lee
Seokjun Oh
Bitna Joo
Jeong-Woo Hwang
Jeongseop Kim
Tae-Eun Kim
Tae-Mi Jung
Yu-Jin Kim

Frontiers in Immunology

doi 10.3389/fimmu.2025.1661791

3,013 views
1 citation

Original Research

Published on 07 Nov 2025

Prognostic value of kappa free light chain index in patients with primary progressive multiple sclerosis

in Multiple Sclerosis and Neuroimmunology

Martin Schmidauer
Klaus Berek
Michael Auer
Gabriel Bsteh
Paola Cavalla
Franziska Di Pauli
Massimiliano Di Filippo
Florian Deisenhammer
Andreja Emeršič
Fabian Föttinger

Frontiers in Immunology

doi 10.3389/fimmu.2025.1658182

2,324 views

Original Research

Published on 04 Nov 2025

Sex differences in abnormal gluten response and predictors of gluten sensitivity in patients with schizophrenia

in Multiple Sclerosis and Neuroimmunology

Michał Dzikowski
Joanna Rog
Dariusz Juchnowicz
Anna Rymuszka
Hanna Karakula-Juchnowicz

Frontiers in Immunology

doi 10.3389/fimmu.2025.1696763

1,425 views

Review

Published on 30 Oct 2025

The mechanisms of specialized pro-resolving mediators in pain relief: neuro-immune and neuroglial regulations

in Multiple Sclerosis and Neuroimmunology

Yushan Chen
Xuewei Wu
Jiaqi Li
Yuxuan Ren
He Miao
Xiaojie Zhai
Changshun Huang
Xiaowei Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1634724

3,474 views
1 citation

Original Research

Published on 29 Oct 2025

Antibodies to myelin oligodendrocyte glycoprotein in optic perineuritis

in Multiple Sclerosis and Neuroimmunology

Shanshan Cao
Yuan Zhang
Xintong Xu
Mingming Sun
Chunyan Pan
Yuhang Wang
Shihui Wei
Quangang Xu
Huanfen Zhou

Frontiers in Immunology

doi 10.3389/fimmu.2025.1657600

1,349 views

1,513 articles

articles

Disproportionality analysis of drug-associated progressive multifocal leukoencephalopathy: roles of underlying diseases and immunomodulatory therapies in FAERS

Macrophages as central mediators of sympathetic neuro-immune interplay in autoimmunity

Case report of intracranial tumor with serum MOG-IgG positivity

Brain TRPV1 channel-mediated calcium influx: the immunomodulatory pathway of acupuncture in neuroinflammation

Glymphatic dysfunction in neuromyelitis optica spectrum disorder

Neuronal autoantibodies associated with poorer neuropsychological and motor outcomes 6 months after stroke: Results from the PHYS-STROKE trial

Brain-infiltrated monocyte macrophages in a rat model of temporal lobe epilepsy: revisiting the pro-inflammatory paradigm

Autoimmune cerebellopyramidal syndrome as a complex form of autoimmune cerebellar ataxia: a cohort study

Visualized knowledge mapping on the current research trends and emerging areas of neuroimmune modulation in the past two decades

Beyond the cut-off: harmonizing kappa free light chain index using likelihood ratios improves the clinical interpretation in the diagnosis of multiple sclerosis

Dual role of complement in neuronal repair

Reduced CD40 expression in B cell subsets of individuals with radiologically isolated syndrome

Modeling lymphocyte subset dynamics after ublituximab therapy in patients with multiple sclerosis: an Italian prospective study

The critical role of Th17 cells and IL-17A in autoimmune and inflammation-associated neurological diseases: mechanisms and therapeutic perspectives

Neuroimmune modulatory effects of the NLRP3 inflammasome: the role of sex and living environment in brain affecting conditions

Correction: Polysialic acid restrains inflammatory monocyte maturation

Decoding tRNA dynamics in neuroimmune disorders: mechanistic insights, diagnostic innovations, and therapeutic opportunities

Vaccination and COVID-19: impact on long-COVID

Natalizumab and fumarate treatment differentially modulate CD4+ T cell and B cell subtypes in multiple sclerosis patients without impacting durable COVID-19 vaccine responses

Genetic knockdown of DYRK1A attenuates cognitive impairment, Aβ pathology, tauopathy and neuroinflammatory responses in mouse models of AD

Prognostic value of kappa free light chain index in patients with primary progressive multiple sclerosis

Sex differences in abnormal gluten response and predictors of gluten sensitivity in patients with schizophrenia

The mechanisms of specialized pro-resolving mediators in pain relief: neuro-immune and neuroglial regulations

Antibodies to myelin oligodendrocyte glycoprotein in optic perineuritis