Frontiers in Molecular Biosciences | Molecular Diagnostics and Therapeutics

Original Research

Published on 03 Sep 2025

Establishment and application of a preset dilution factor strategy for human chorionic gonadotropin testing in clinical laboratory

in Molecular Diagnostics and Therapeutics

Shu Chen
Qin Li
Huaqiang Liao
Mingcai Zhao
Jie Chen
Hongyu Chen
Guangjun Xiao

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1648421

2,087 views
1 citation

Original Research

Published on 02 Sep 2025

The association between composite inflammatory indicators and the clinicopathological characteristics of differentiated thyroid carcinoma

in Molecular Diagnostics and Therapeutics

Li-Yuan Yang
Li-Peng Yang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1660379

1,984 views

Correction

Published on 01 Sep 2025

Correction: Promotion of neuroinflammation in select hippocampal regions in a mouse model of perimenopausal Alzheimer’s disease

in Molecular Diagnostics and Therapeutics

Roberta Marongiu
Jimcy Platholi
Laibaik Park
Fangmin Yu
Garrett Sommer
Clara Woods
Teresa A. Milner
Michael J. Glass

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1684511

1,495 views

Original Research

Published on 01 Sep 2025

Gut microbiota-metabolome remodeling associated with low bone mass: an integrated multi-omics study in fracture patients

in Molecular Diagnostics and Therapeutics

Xian Zhao
Bin Wu
Pengli Han
Zhongyu Wang
Renwei Cao
Shuo Chen
Cheng Cheng
Hongkai Lian
Yejun Zha
Minjuan Li

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1646361

2,726 views
1 citation

Review

Published on 29 Aug 2025

The emerging role of exosomal LncRNAs in chronic fatigue syndrome: from intercellular communication to disease biomarkers

in Molecular Diagnostics and Therapeutics

Lei Wang
Yujia Xu
Xiang Zhong
Guiping Wang
Zijun Shi
Can Mei
Linwanyue Chen
Jianbo Zhan
Jing Cheng

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1653627

3,802 views
2 citations

Original Research

Published on 22 Aug 2025

The protection of sulforaphane on subarachnoid hemorrhage-induced intestinal mucosa injury in rats

in Molecular Diagnostics and Therapeutics

Zixiang Liu
Pengpeng Li
Yuanhai Zhang
Shidi Zhao
Wei Gao

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1635795

2,245 views

Review

Published on 21 Aug 2025

Artificial intelligence in primary aldosteronism: current achievements and future challenges

in Molecular Diagnostics and Therapeutics

Yisi Xu
Benjin Liu
Xuqi Huang
Xudong Guo
Ning Suo
Shaobo Jiang
Hanbo Wang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1660588

6,960 views

Review

Published on 20 Aug 2025

Molecular mechanisms and therapeutic advances of peritubular capillary neogenesis in acute kidney injury

in Molecular Diagnostics and Therapeutics

Yuming Ding
Linmei Gao
Yi Chen
Yanheng Qiao
Bo Yang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1643838

3,339 views
1 citation

Original Research

Published on 20 Aug 2025

Performance and clinical implications of non-invasive prenatal testing for rare chromosomal abnormalities: a retrospective study of 94,125 cases

in Molecular Diagnostics and Therapeutics

Haimei Qi
Haijun Chen
Zhuling Zhang
Jinhui Gan
Huifeng Liu
Xianping Yuan
Fuyu Luo
Junkun Chen
Shichun Shen

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1645223

3,337 views
1 citation

Original Research

Published on 20 Aug 2025

Shared transcriptional regulators and network rewiring identify therapeutic targets linking type 2 diabetes mellitus and hypertension

in Molecular Diagnostics and Therapeutics

Claudia Desireé Norzagaray-Valenzuela
Marco Antonio Valdez-Flores
Josue Camberos-Barraza
Alberto Kousuke De la Herrán-Arita
Juan Fidel Osuna-Ramos
Javier Magaña-Gómez
Carla Angulo-Rojo
Alma Marlene Guadrón-Llanos
Katia Aviña-Padilla
Loranda Calderón-Zamora

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1621413

3,013 views

Original Research

Published on 20 Aug 2025

Identification of kidney renal clear cell carcinoma prognosis based on gene expression and clinical information

in Molecular Diagnostics and Therapeutics

Xiong Zou
Xi Chen
Jianjun Yang
Yanfeng Li

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1630250

1,944 views

Original Research

Published on 15 Aug 2025

Preoperative serum inflammatory markers in the prognostic assessment of hepatocellular carcinoma resection in stages I/II

in Molecular Diagnostics and Therapeutics

Fan Liu
Yuan Xiang
Hao Xu
Xiaoxue Xu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1640390

1,741 views
1 citation

Original Research

Published on 15 Aug 2025

Identification of anoikis-related genes classification patterns and immune infiltration characterization in chronic rhinosinusitis with nasal polyps based on machine learning

in Molecular Diagnostics and Therapeutics

Ziqi Chen
Lingmei Qu
Qing Hao
Shuang Teng
Shuo Liu
Qin Wu
Hongtian Yi
Xianji Shen
Liang Li
Zhaonan Xu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1624300

2,046 views

Original Research

Published on 14 Aug 2025

RetinalVasNet: a deep learning approach for robust retinal microvasculature detection

in Molecular Diagnostics and Therapeutics

Zhaomin Yao
Cengcong Xing
Gancheng Zhu
Weiming Xie
Zhiguo Wang
Guoxu Zhang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1562608

2,184 views
1 citation

Original Research

Published on 14 Aug 2025

Comprehensive proteomic characterization of pulmonary arterial hypertension in Chinese people

in Molecular Diagnostics and Therapeutics

Tianya Liu
Siqi Zhou
Rui Wang
Xiaomei Xu
Fang Gao
Jie Zu
Zhiping Wang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1652083

2,544 views

Original Research

Published on 08 Aug 2025

Identification and verification of biomarkers associated with neutrophils in acute myocardial infarction: integrated analysis of bulk RNA-seq, expression quantitative trait loci, and mendelian randomization

in Molecular Diagnostics and Therapeutics

Guoqing Liu
Xiangwen Lv
Jiahui Qin
Xingqing Long
Miaomiao Zhu
Chuwen Fu
Jian Xie
Peichun He

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1614350

2,585 views

Original Research

Published on 08 Aug 2025

CCDC138 overexpression predicts poor prognosis and highlights ciliopathy-linked mechanisms in uterine corpus endometrial carcinoma

in Molecular Diagnostics and Therapeutics

Aiping Wang
Fang Yang
Chunhua Zhang
Shi Li
Han Fu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1622496

2,172 views

Review

Published on 07 Aug 2025

The potential role of non-coding RNAs in acute kidney injury: a focus on natural medicine treatment

in Molecular Diagnostics and Therapeutics

Yuxin Guo
Yanru Zhao
Hanqing Zhang
Yunze Xing
Yaxuan Fang
Dingyuan Zheng
Hanqi Yang
Yanheng Qiao
Bo Yang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1648526

2,325 views
1 citation

Original Research

Published on 06 Aug 2025

Shared molecular profiles of post-laser vision correction ectasia and keratoconus with key differences in CADPS, CPT1B, CIITA, and TBC1D4

in Molecular Diagnostics and Therapeutics

Katarzyna Jaskiewicz-Rajewicz
Alicja Wysocka
Magdalena Maleszka-Kurpiel
Eliza Matuszewska-Mach
Jakub Wozniak
Rafal Ploski
Jan Matysiak
Malgorzata Rydzanicz
Marzena Gajecka

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1616675

2,463 views

Original Research

Published on 06 Aug 2025

Using machine learning methods to investigate the role of volatile organic compounds in non-alcoholic fatty liver disease

in Molecular Diagnostics and Therapeutics

Chih-Hao Shen
Ruei-Hao Huang
Yaw-Kuen Li
Ta-Wei Chu
Dee Pei

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1631265

2,542 views
1 citation

Original Research

Published on 04 Aug 2025

Inflammation-nutrition biomarker model for survival prediction in lung cancer patients with concurrent tuberculosis

in Molecular Diagnostics and Therapeutics

Hongqi Zhou
Zihao Zhao
Jinhai Wang
Weiyun Jin
Bensong Xian
Lindi Li
XiangWen Nie
WeiWei Wu
Ran Chen
QiZhen Xie

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1624131

2,369 views

Technology and Code

Published on 01 Aug 2025

Enhancing head and neck cancer detection accuracy in digitized whole-slide histology with the HNSC-classifier: a deep learning approach

in Molecular Diagnostics and Therapeutics

Haiyang Yu
Wang Yu
Yuan Enwu
Jun Ma
Xin Zhao
Linlin Zhang
Fang Yang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1652144

2,337 views

Original Research

Published on 01 Aug 2025

A comprehensive analysis of the tryptophan metabolism-related gene signature to predict the prognosis of esophageal squamous cell carcinoma based on multi-omics

in Molecular Diagnostics and Therapeutics

Zhengjie Wu
Zhiping Liu
Yukun Wang
Geling Teng
Xiaodong Li
Tong Lu
Fangning Hu
Shuo Wu
Guanqiang Ma
Hua Zhang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1613539

2,796 views
1 citation

Original Research

Published on 01 Aug 2025

Prognostic value of positive lymph node ratio, tumor deposit, and perineural invasion in advanced colorectal signet-ring cell carcinoma

in Molecular Diagnostics and Therapeutics

Liang Chu
Han Wang
Tao Ling
Shuhan Feng
Yucheng Ding
Yan Zhang
Ying Pan
Cenzhu Wang
Xiaohong Wang
Lei Liu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1617787

1,819 views

2,139 articles

articles

Establishment and application of a preset dilution factor strategy for human chorionic gonadotropin testing in clinical laboratory

The association between composite inflammatory indicators and the clinicopathological characteristics of differentiated thyroid carcinoma

Correction: Promotion of neuroinflammation in select hippocampal regions in a mouse model of perimenopausal Alzheimer’s disease

Gut microbiota-metabolome remodeling associated with low bone mass: an integrated multi-omics study in fracture patients

The emerging role of exosomal LncRNAs in chronic fatigue syndrome: from intercellular communication to disease biomarkers

The protection of sulforaphane on subarachnoid hemorrhage-induced intestinal mucosa injury in rats

Artificial intelligence in primary aldosteronism: current achievements and future challenges

Molecular mechanisms and therapeutic advances of peritubular capillary neogenesis in acute kidney injury

Performance and clinical implications of non-invasive prenatal testing for rare chromosomal abnormalities: a retrospective study of 94,125 cases

Shared transcriptional regulators and network rewiring identify therapeutic targets linking type 2 diabetes mellitus and hypertension

Identification of kidney renal clear cell carcinoma prognosis based on gene expression and clinical information

Preoperative serum inflammatory markers in the prognostic assessment of hepatocellular carcinoma resection in stages I/II

Identification of anoikis-related genes classification patterns and immune infiltration characterization in chronic rhinosinusitis with nasal polyps based on machine learning

RetinalVasNet: a deep learning approach for robust retinal microvasculature detection

Comprehensive proteomic characterization of pulmonary arterial hypertension in Chinese people

Identification and verification of biomarkers associated with neutrophils in acute myocardial infarction: integrated analysis of bulk RNA-seq, expression quantitative trait loci, and mendelian randomization

CCDC138 overexpression predicts poor prognosis and highlights ciliopathy-linked mechanisms in uterine corpus endometrial carcinoma

The potential role of non-coding RNAs in acute kidney injury: a focus on natural medicine treatment

Shared molecular profiles of post-laser vision correction ectasia and keratoconus with key differences in CADPS, CPT1B, CIITA, and TBC1D4

Using machine learning methods to investigate the role of volatile organic compounds in non-alcoholic fatty liver disease

Inflammation-nutrition biomarker model for survival prediction in lung cancer patients with concurrent tuberculosis

Enhancing head and neck cancer detection accuracy in digitized whole-slide histology with the HNSC-classifier: a deep learning approach

A comprehensive analysis of the tryptophan metabolism-related gene signature to predict the prognosis of esophageal squamous cell carcinoma based on multi-omics

Prognostic value of positive lymph node ratio, tumor deposit, and perineural invasion in advanced colorectal signet-ring cell carcinoma