Frontiers in Oncology | Cancer Cell Signaling

Systematic Review

Published on 16 Jul 2026

The dual role of parasites and parasite-derived products in cancer biology: a systematic review of in vitro and in vivo evidence

in Cancer Cell Signaling

Faisal Minshawi
Maimonah Alghanmi
Hassan Alwafi
Amal Mohammad Dustakir
Bayan Al Zoabi
Saleha Khan
Hattan S. Gattan
Isra M. Alsaady
Sarah A. Altwaim
Tope Oyelade

Frontiers in Oncology

doi 10.3389/fonc.2026.1894132

403 views

Review

Published on 03 Jul 2026

Aurora kinase B as a therapeutic target in HPV-induced cervical cancer: mechanisms and future perspectives

in Cancer Cell Signaling

Medha Karnik
Preethi G. Anantharaju
Arati Sharma
Olga Sukocheva
Edmund Tse
SubbaRao V. Madhunapantula

Frontiers in Oncology

doi 10.3389/fonc.2026.1857128

490 views

Original Research

Accepted on 29 Jun 2026

Sweet Apple E-Cigarette Vapor Differentially Activates the mTOR Pathway in Oral Squamous Cell Carcinoma Cell Lines

in Cancer Cell Signaling

Kristina VU
Logan Ponder
Ryan Kinney
Ankita Chatterje
Harishma Sidhu
Neha Patel
Benjamin T Bikman
Paul R Reynolds
Juan A Arroyo

Frontiers in Oncology

147 views

Original Research

Published on 23 Jun 2026

Evaluation of the CIB1R peptide derived from the cytoplasmic domain of neprilysin on cell migration in an in vitro model of lung cancer

in Cancer Cell Signaling

Carlos Alejandro Martínez-Armenta
Horacio Almanza-Reyes
Leslie Patrón-Romero
Adriana Sampayo-Reyes
Juan M. Alcocer-González
Reyes Tamez-Guerra
Cristina Rodríguez-Padilla
Humberto Antonio Salazar-Sesatty
Omar Zardain-Medlich-Ducoulombier
Francisco González-Salazar

Frontiers in Oncology

doi 10.3389/fonc.2026.1825515

1,576 views

Original Research

Published on 22 Jun 2026

Quantitative phosphoproteomic profiling of CCL5/CCR5 signaling cascade in melanoma cells

in Cancer Cell Signaling

Lifen Xie
Tianhui Zhu
An He
Qin Wu
Jinfeng Zeng
Liqin Huang
Ling Zhang
Jie Liu

Frontiers in Oncology

doi 10.3389/fonc.2026.1852022

1,017 views

Review

Accepted on 15 Jun 2026

Disrupting the CCND1–CDK4 Protein-Protein Interaction: Emerging Strategies to Target Cyclin D–Dependent Kinase Assembly in Cancer

in Cancer Cell Signaling

Emadeldin Kamel
Sally Mostafa Khadrawy
Mohamed A. M. Ali
Noha A. Ahmed
Mostafa R. Abukhadra
Saleh Alkhedhairi
Faris F. Aba Alkhayl
Al Mokhtar Lamsabhi

Frontiers in Oncology

362 views

Case Report

Published on 29 May 2026

Ovarian endometrioid carcinoma with sex cord-like features: a case report with genomic and transcriptomic analyses and literature review

in Cancer Cell Signaling

Shanshan Guo
Qianjue Tang
Jie Zhang
Wei Zhao
Siru Chen
Hong Xia
Chunyan Zhang
Xiaoyun Zhang

Frontiers in Oncology

doi 10.3389/fonc.2026.1826424

1,100 views

Original Research

Published on 29 May 2026

Study of ß-catenin signaling pathway modulated by PTHrP in cell and animal colorectal cancer models

in Cancer Cell Signaling

Cintia Birkenstok
Pedro Carriere
María Belén Novoa Díaz
María Julia Martín
Claudia Gentili

Frontiers in Oncology

doi 10.3389/fonc.2026.1773635

984 views

Original Research

Published on 15 Apr 2026

POLR2J knockdown promotes ROS-induced DDR and ferroptosis by inhibiting the STAT3-GPX4 signaling axis in LUAD

in Cancer Cell Signaling

Jiehong Wang
Jiaojiao Chen
Xue Zhu
Yue Hao
Jing Fang
Naiyan Lu
Ke Wang
Xun Wang

Frontiers in Oncology

doi 10.3389/fonc.2026.1787943

1,200 views

Review

Published on 19 Mar 2026

Regulation of glycosylation in radiotherapy: exploring the multiple effects of DNA damage, immune response, stromal microenvironment and metabolism

in Cancer Cell Signaling

Wenqing Cui
Mengqian Jiang
Ran Zhang
Jinming Yu
Dawei Chen

Frontiers in Oncology

doi 10.3389/fonc.2026.1758628

2,164 views

Original Research

Published on 18 Mar 2026

DEPDC7 as a potential tumor suppressor in hepatocellular carcinoma: preliminary evidence for targeting the JAK1/STAT3 axis

in Cancer Cell Signaling

Zhijun Liao
Changhao Bao
Jiaqi Wang
Genwang Chen
Sisi Gong
Jiewei Huang
Jie Liu
Ruiyang Huang
Qilong Pan
Chunmei Fan

Frontiers in Oncology

doi 10.3389/fonc.2026.1719731

1,056 views

Review

Published on 13 Mar 2026

Aptamers targeting immune checkpoints for tumor immunotherapy: a comprehensive review

in Cancer Cell Signaling

Manas Kumar Gedla
Renuka Sai Priya Kotla
Revathy Kumar
Venkatesh Kamesh
Joshua S
Dhanabalan Kamalakannan
Jubilee Ramasamy

Frontiers in Oncology

doi 10.3389/fonc.2026.1762902

2,194 views

Mini Review

Published on 11 Feb 2026

Lung adenocarcinoma with KRAS-Q61H: clinicopathologic features, diagnostics, and the evolving treatment landscape

in Cancer Cell Signaling

Ioannis Serafimidis

Frontiers in Oncology

doi 10.3389/fonc.2026.1771549

2,521 views

Mini Review

Published on 02 Feb 2026

Targeting β-catenin: PROTACs and precision degraders for Wnt-driven cancers

in Cancer Cell Signaling

Jonathan Trapani
Kailey P. Caroland
Yashi Ahmed
David J. Robbins
Vivian L. Weiss
Ethan Lee

Frontiers in Oncology

doi 10.3389/fonc.2026.1777843

5,013 views
4 citations

Review

Published on 13 Jan 2026

Mechanotransduction of Piezo1 in the cancer microenvironment: implications for NK cell-based immunotherapy

in Cancer Cell Signaling

Xinmu Cui
Binbin Zhang
Jianan Zhao
Huajie Tian

Frontiers in Oncology

doi 10.3389/fonc.2025.1729588

3,436 views
6 citations

Review

Published on 09 Jan 2026

Ferroptosis: a new dawn in the treatment of acute lymphoblastic leukemia

in Cancer Cell Signaling

Jiongping Han
Yifan Yang
Yuxin Wei
Jing Jin
Weiying Feng

Frontiers in Oncology

doi 10.3389/fonc.2025.1669432

2,284 views
2 citations

Systematic Review

Published on 17 Dec 2025

Global research trends in signaling pathways of spasmolytic polypeptide-expressing metaplasia pathogenesis: a bibliometric analysis

in Cancer Cell Signaling

Qiumiao Xu
Zhijiang Dai
Chengjin Peng
Qinghong Yan
Xiaoting Chen
Tongwei Liu
Ran Zhang
Guoxin Huang
Xinyao Liu
Jingbin Wang

Frontiers in Oncology

doi 10.3389/fonc.2025.1597221

2,712 views

Review

Published on 10 Dec 2025

HMGCR: a malignancy hub - frontiers in cancer diagnosis and therapy

in Cancer Cell Signaling

Yisong Yang
Yiting Liu
Teng Zou
Jiazhuo Liu
Xingzhi Zhou
Ran Tao
Shuangping Liu

Frontiers in Oncology

doi 10.3389/fonc.2025.1698320

3,283 views
3 citations

Review

Published on 01 Dec 2025

The S100 protein family in bladder cancer: mechanisms, clinical value, and targeted therapeutic prospects

in Cancer Cell Signaling

Lihao Zhang
Gang Yang
Lige Huang
Aijia Deng
Mengxin Ao
Jiabing Li

Frontiers in Oncology

doi 10.3389/fonc.2025.1683039

2,612 views

Review

Published on 21 Nov 2025

Norrin in cancer: from a promising prognostic biomarker to a novel therapeutic target

in Cancer Cell Signaling

Jiaqing Zhang
Zhengyi Zhang
Huabao Xiong
Guanjun Dong
Lu Yu

Frontiers in Oncology

doi 10.3389/fonc.2025.1692715

2,268 views

Original Research

Published on 13 Nov 2025

Circ_0060927 regulates miR-331-3p/ERK/MAPK pathway reaction in non-small cell lung cancer through METTL14-driven methylation

in Cancer Cell Signaling

Yang Liao
Ji Song
Chun Luo
Jin Xiang
Sheng Cheng

Frontiers in Oncology

doi 10.3389/fonc.2025.1609215

1,748 views

Original Research

Published on 06 Nov 2025

Correlation between different levels of Her-2 protein expression and the efficacy of neoadjuvant therapy in Her-2 positive breast cancer

in Cancer Cell Signaling

Wen-hui Wang
Hong-bo Li
Zhong-yuan Cui
Yan-dong Li
Zhi-yong Wang

Frontiers in Oncology

doi 10.3389/fonc.2025.1673234

1,792 views

Review

Published on 08 Oct 2025

From miRNA sponges to mTOR blockades: mapping the multidimensional landscape of ameloblastoma pathogenesis and precision targeting

in Cancer Cell Signaling

Jingsong Mao
Qingxuan Gai
Xinling Bao
Ming Zhong

Frontiers in Oncology

doi 10.3389/fonc.2025.1651236

3,804 views
1 citation

Original Research

Published on 22 Sep 2025

A systematic review and meta-analysis of the effects of green tea extracts and polyphenols in female hormone-dependent cancers for benefit-risk evaluation

in Cancer Cell Signaling

Jin-jing He
Yan-fang Zhang
Ze-huang He
Lei Zheng

Frontiers in Oncology

doi 10.3389/fonc.2025.1579470

9,202 views
1 citation

54 articles

articles

The dual role of parasites and parasite-derived products in cancer biology: a systematic review of in vitro and in vivo evidence

Aurora kinase B as a therapeutic target in HPV-induced cervical cancer: mechanisms and future perspectives

Sweet Apple E-Cigarette Vapor Differentially Activates the mTOR Pathway in Oral Squamous Cell Carcinoma Cell Lines

Evaluation of the CIB1R peptide derived from the cytoplasmic domain of neprilysin on cell migration in an in vitro model of lung cancer

Quantitative phosphoproteomic profiling of CCL5/CCR5 signaling cascade in melanoma cells

Disrupting the CCND1–CDK4 Protein-Protein Interaction: Emerging Strategies to Target Cyclin D–Dependent Kinase Assembly in Cancer

Ovarian endometrioid carcinoma with sex cord-like features: a case report with genomic and transcriptomic analyses and literature review

Study of ß-catenin signaling pathway modulated by PTHrP in cell and animal colorectal cancer models

POLR2J knockdown promotes ROS-induced DDR and ferroptosis by inhibiting the STAT3-GPX4 signaling axis in LUAD

Regulation of glycosylation in radiotherapy: exploring the multiple effects of DNA damage, immune response, stromal microenvironment and metabolism

DEPDC7 as a potential tumor suppressor in hepatocellular carcinoma: preliminary evidence for targeting the JAK1/STAT3 axis

Aptamers targeting immune checkpoints for tumor immunotherapy: a comprehensive review

Lung adenocarcinoma with KRAS-Q61H: clinicopathologic features, diagnostics, and the evolving treatment landscape

Targeting β-catenin: PROTACs and precision degraders for Wnt-driven cancers

Mechanotransduction of Piezo1 in the cancer microenvironment: implications for NK cell-based immunotherapy

Ferroptosis: a new dawn in the treatment of acute lymphoblastic leukemia

Global research trends in signaling pathways of spasmolytic polypeptide-expressing metaplasia pathogenesis: a bibliometric analysis

HMGCR: a malignancy hub - frontiers in cancer diagnosis and therapy

The S100 protein family in bladder cancer: mechanisms, clinical value, and targeted therapeutic prospects

Norrin in cancer: from a promising prognostic biomarker to a novel therapeutic target

Circ_0060927 regulates miR-331-3p/ERK/MAPK pathway reaction in non-small cell lung cancer through METTL14-driven methylation

Correlation between different levels of Her-2 protein expression and the efficacy of neoadjuvant therapy in Her-2 positive breast cancer

From miRNA sponges to mTOR blockades: mapping the multidimensional landscape of ameloblastoma pathogenesis and precision targeting

A systematic review and meta-analysis of the effects of green tea extracts and polyphenols in female hormone-dependent cancers for benefit-risk evaluation