Frontiers in Oncology | Molecular and Cellular Oncology

Original Research

Published on 05 Jan 2026

Integrative bulk and single-cell transcriptomic analysis reveals COL1A2-driven ECM remodeling and focal adhesion signaling associated with the transition from non-muscle-invasive to muscle-invasive bladder cancer

in Molecular and Cellular Oncology

Menglu Li
Xinwei Liu
Yuhui Xue
Yichen Lu
Zhiqiang Chen
Yuwei Zhang
Weiguo Chen
Shan-Chao Zhao
Ke Wang
Ninghan Feng

Frontiers in Oncology

doi 10.3389/fonc.2025.1716324

1,335 views
1 citation

Original Research

Published on 19 Dec 2025

Quantifying TERT promoter mutations in tumor-derived DNA shed into the oral cavity as a potential biomarker for oral squamous cell carcinoma

in Molecular and Cellular Oncology

Noemy Starita
Marta Tagliabue
Tarik Gheit
Andrea Cerasuolo
Sara Amiranda
Tiziana Pecchillo Cimmino
Luisa Dassi
Anna Lucia Tornesello
Rita De Berardinis
Fausto Maffini

Frontiers in Oncology

doi 10.3389/fonc.2025.1720783

1,390 views

Editorial

Published on 12 Dec 2025

Editorial: Role of nanocarriers and non-coding RNAs in solid malignancies

in Molecular and Cellular Oncology

Rana A. Youness
Sherif Ashraf Fahmy
Eleni K. Efthimiadou
Maria Braoudaki
Gowhar Rashid

Frontiers in Oncology

doi 10.3389/fonc.2025.1737094

530 views

Original Research

Published on 12 Dec 2025

Cetrorelix promotes cell apoptosis via the PI3K–AKT–FOXO1 pathway in epithelial ovarian cancer

in Molecular and Cellular Oncology

Ning Zhang
Yu Liu
Xiaodan Zhang
Meng Xie
Ying Zhang
Keqin Hua

Frontiers in Oncology

doi 10.3389/fonc.2025.1631576

1,065 views

Original Research

Accepted on 11 Dec 2025

Identification of ZFP161 as a regulator of the c-Myc oncogene in human colon tissue

in Molecular and Cellular Oncology

Grania Christyani
Fei Zhao
Yening Feng
Hyorin Lee
XINYI TU
Chao Zhang
Zhenkun Lou
Wootae Kim

Frontiers in Oncology

301 views

Original Research

Published on 04 Dec 2025

FGF21 inhibits invasion and metastasis via IL-17A-Notch in pancreatic ductal adenocarcinoma

in Molecular and Cellular Oncology

Fangdan Li
Panchun Zheng
Xiongwu Li
Yaying Yang
Hangyu Zhou
Linjun Li

Frontiers in Oncology

doi 10.3389/fonc.2025.1680888

1,122 views

Mini Review

Published on 04 Dec 2025

Rewiring immune evasion in liver metastases: WNT11 as a central node — a mini review

in Molecular and Cellular Oncology

Xiaoling Wang
Youcai Huang
Tingting Luo
Qinxian Liu
Yu Tian
Xiaoyu Hu
Yi Zheng
Shumin Fang
Yanyang Tu
Haining Zhen

Frontiers in Oncology

doi 10.3389/fonc.2025.1666889

1,290 views

Review

Published on 03 Dec 2025

Recent progress in serine metabolism reprogramming in tumors and strategies for serine deprivation

in Molecular and Cellular Oncology

Huimei Liu
Yanping Liu

Frontiers in Oncology

doi 10.3389/fonc.2025.1669565

1,105 views
1 citation

Review

Published on 02 Dec 2025

Deciphering molecular pathways driving cancer invasion and metastasis: advances and therapeutic prospects

in Molecular and Cellular Oncology

Aziza Alshahrani
Arwa Alsubait
Zahrah Asiri
Sahar Alghamdi
Sarah Bin Saqyah
Tariq Alqahtani
Rawan Fitaihi
Njoud Altuwaijri
Yahya F. Jamous

Frontiers in Oncology

doi 10.3389/fonc.2025.1684896

2,118 views
1 citation

Correction

Published on 02 Dec 2025

Correction: ABLIM1: a novel oncogenic E3 ligase in colorectal cancer

in Molecular and Cellular Oncology

Frontiers Production Office

Frontiers in Oncology

doi 10.3389/fonc.2025.1753402

618 views

Original Research

Published on 25 Nov 2025

Integrative modeling of FOXO-mediated autophagy in NSCLC: linking cGAS–STING signaling to IL-6 dynamics

in Molecular and Cellular Oncology

Divya Rani
Shweta Khandibharad
Shailza Singh

Frontiers in Oncology

doi 10.3389/fonc.2025.1689137

1,662 views

Original Research

Published on 24 Nov 2025

BAG3 in human tumors

in Molecular and Cellular Oncology

Paola Manzo
Anna Lisa Cammarota
Jelena Dimitrov
Antonia Falco
Alessandra Rosati
Liberato Marzullo
Maria Caterina Turco
Vincenzo De Laurenzi
Gianluca Sala
Margot De Marco

Frontiers in Oncology

doi 10.3389/fonc.2025.1725674

1,000 views

Case Report

Published on 24 Nov 2025

Case Report: Blood single-cell analysis of a IVB high-grade serous ovarian cancer patient presenting a favorable prognosis

in Molecular and Cellular Oncology

Martyna Wolańska
Michał Sieczczyński
Krzysztof Pastuszak
Anna Samelak-Czajka
Paulina Jackowiak
Natalia Bednarz-Knoll
Sylwia Łapińska-Szumczyk
Dagmara Klasa-Mazurkiewicz
Anna J. Żaczek
Anna Supernat

Frontiers in Oncology

doi 10.3389/fonc.2025.1697863

1,479 views

Opinion

Published on 20 Nov 2025

ABLIM1: A novel oncogenic E3 ligase in colorectal cancer

in Molecular and Cellular Oncology

Ganesh Kumar Barik
Osheen Sahay
Sehbanul Islam

Frontiers in Oncology

doi 10.3389/fonc.2025.1718420

1,482 views

Review

Published on 11 Nov 2025

Post-translational modifications of protein and lung cancer

in Molecular and Cellular Oncology

Ying Zhao
Xiaoyu Song
WenFeng Luo
Fangmei Xie
Jian Shen
JinHua He
Zeping Han
Jinju Huang

Frontiers in Oncology

doi 10.3389/fonc.2025.1667200

1,975 views
1 citation

Original Research

Published on 06 Nov 2025

PPP2CA knockdown upregulates the expression levels of ferroptosis-related genes TFRC and ACSL4 in colorectal cancer cells by promoting mTOR phosphorylation

in Molecular and Cellular Oncology

Jing Cheng
Zhihan Liu
Haibo Liu
Chao Fang
Jun Li

Frontiers in Oncology

doi 10.3389/fonc.2025.1694932

1,181 views

Original Research

Published on 28 Oct 2025

Temporal dynamics of cisplatin-induced endothelial senescence and its association with cognitive impairment: insights into the medial prefrontal cortex

in Molecular and Cellular Oncology

Yue Hei
Sheng-nan Kong
Juan-hua Sun
Wei-ping Liu
Qian-fa Long
Hong-mei Zhang

Frontiers in Oncology

doi 10.3389/fonc.2025.1668372

1,421 views

Original Research

Published on 27 Oct 2025

An early-stage 3D fibroblast-featured tumor model mimics the gene expression of the naïve tumor microenvironment, including genes involved in cancer progression and drug resistance

in Molecular and Cellular Oncology

Francesca Costabile
Subin George
Andrea Facciabene
Gilberto Filaci
Maddalena Mastrogiacomo

Frontiers in Oncology

doi 10.3389/fonc.2025.1572315

1,581 views

Review

Accepted on 21 Oct 2025

Improving Radiation Therapy Efficacy Considering DNA Repair, TP53 Mutations, Microscopic Heterogeneity and Low & High Dose Apoptosis

in Molecular and Cellular Oncology

Anders Brahme

Frontiers in Oncology

258 views

Review

Published on 21 Oct 2025

Long noncoding RNAs involved in therapeutic response: implications for cervical cancer drug resistance

in Molecular and Cellular Oncology

Samuel Trujano-Camacho
Carlos Contreras-Romero
Verónica García-Castillo
David Sánchez-Marín
Mercedes Olvera-Valencia
Mauricio Rodríguez-Dorantes
Oscar Peralta-Zaragoza
David Cantú de León
Eduardo López-Urrutia
Carlos Pérez-Plasencia

Frontiers in Oncology

doi 10.3389/fonc.2025.1644104

1,541 views

Editorial

Published on 09 Oct 2025

Editorial: Interplay of immunity and ECM in cancer

in Molecular and Cellular Oncology

Albina Fejza
Federica Benvenuti
Eva Andreuzzi

Frontiers in Oncology

doi 10.3389/fonc.2025.1704061

1,594 views
1 citation

Mini Review

Published on 07 Oct 2025

Context-dependent rewiring of dual-function proteins in cancer: a sequential strategy to restore apoptosis

in Molecular and Cellular Oncology

Leon Strzadala

Frontiers in Oncology

doi 10.3389/fonc.2025.1675537

2,092 views

Review

Published on 07 Oct 2025

MicroRNAs and lung cancer: overview of essential pathways and somatic mutations in cancer progression

in Molecular and Cellular Oncology

Andrei-Alexandru Tirpe
Andreea Nutu
Constantin Busuioc
Ovidiu-Laurean Pop
Ioana Berindan-Neagoe

Frontiers in Oncology

doi 10.3389/fonc.2025.1677471

2,946 views
2 citations

Original Research

Published on 03 Oct 2025

Next-generation sequencing-based genomic profiling of advanced soft tissue and bone sarcomas

in Molecular and Cellular Oncology

Yasemin Gündoğdu
Elif Şenocak Taşçı
Leyla Özer
Can Boynukara
Recep Çeçen
Arda Ulaş Mutlu
İbrahim Yıldız

Frontiers in Oncology

doi 10.3389/fonc.2025.1627452

3,137 views
1 citation

3,144 articles

articles

Integrative bulk and single-cell transcriptomic analysis reveals COL1A2-driven ECM remodeling and focal adhesion signaling associated with the transition from non-muscle-invasive to muscle-invasive bladder cancer

Quantifying TERT promoter mutations in tumor-derived DNA shed into the oral cavity as a potential biomarker for oral squamous cell carcinoma

Editorial: Role of nanocarriers and non-coding RNAs in solid malignancies

Cetrorelix promotes cell apoptosis via the PI3K–AKT–FOXO1 pathway in epithelial ovarian cancer

Identification of ZFP161 as a regulator of the c-Myc oncogene in human colon tissue

FGF21 inhibits invasion and metastasis via IL-17A-Notch in pancreatic ductal adenocarcinoma

Rewiring immune evasion in liver metastases: WNT11 as a central node — a mini review

Recent progress in serine metabolism reprogramming in tumors and strategies for serine deprivation

Deciphering molecular pathways driving cancer invasion and metastasis: advances and therapeutic prospects

Correction: ABLIM1: a novel oncogenic E3 ligase in colorectal cancer

Integrative modeling of FOXO-mediated autophagy in NSCLC: linking cGAS–STING signaling to IL-6 dynamics

BAG3 in human tumors

Case Report: Blood single-cell analysis of a IVB high-grade serous ovarian cancer patient presenting a favorable prognosis

ABLIM1: A novel oncogenic E3 ligase in colorectal cancer

Post-translational modifications of protein and lung cancer

PPP2CA knockdown upregulates the expression levels of ferroptosis-related genes TFRC and ACSL4 in colorectal cancer cells by promoting mTOR phosphorylation

Temporal dynamics of cisplatin-induced endothelial senescence and its association with cognitive impairment: insights into the medial prefrontal cortex

An early-stage 3D fibroblast-featured tumor model mimics the gene expression of the naïve tumor microenvironment, including genes involved in cancer progression and drug resistance

Improving Radiation Therapy Efficacy Considering DNA Repair, TP53 Mutations, Microscopic Heterogeneity and Low & High Dose Apoptosis

Long noncoding RNAs involved in therapeutic response: implications for cervical cancer drug resistance

Editorial: Interplay of immunity and ECM in cancer

Context-dependent rewiring of dual-function proteins in cancer: a sequential strategy to restore apoptosis

MicroRNAs and lung cancer: overview of essential pathways and somatic mutations in cancer progression

Next-generation sequencing-based genomic profiling of advanced soft tissue and bone sarcomas