Frontiers in Oncology | Molecular and Cellular Oncology

Original Research

Published on 27 Oct 2025

An early-stage 3D fibroblast-featured tumor model mimics the gene expression of the naïve tumor microenvironment, including genes involved in cancer progression and drug resistance

in Molecular and Cellular Oncology

Francesca Costabile
Subin George
Andrea Facciabene
Gilberto Filaci
Maddalena Mastrogiacomo

Frontiers in Oncology

doi 10.3389/fonc.2025.1572315

1,206 views

Review

Accepted on 21 Oct 2025

Improving Radiation Therapy Efficacy Considering DNA Repair, TP53 Mutations, Microscopic Heterogeneity and Low & High Dose Apoptosis

in Molecular and Cellular Oncology

Anders Brahme

Frontiers in Oncology

158 views

Review

Published on 21 Oct 2025

Long noncoding RNAs involved in therapeutic response: implications for cervical cancer drug resistance

in Molecular and Cellular Oncology

Samuel Trujano-Camacho
Carlos Contreras-Romero
Verónica García-Castillo
David Sánchez-Marín
Mercedes Olvera-Valencia
Mauricio Rodríguez-Dorantes
Oscar Peralta-Zaragoza
David Cantú de León
Eduardo López-Urrutia
Carlos Pérez-Plasencia

Frontiers in Oncology

doi 10.3389/fonc.2025.1644104

1,165 views

Editorial

Published on 09 Oct 2025

Editorial: Interplay of immunity and ECM in cancer

in Molecular and Cellular Oncology

Albina Fejza
Federica Benvenuti
Eva Andreuzzi

Frontiers in Oncology

doi 10.3389/fonc.2025.1704061

1,299 views
1 citation

Review

Published on 07 Oct 2025

MicroRNAs and lung cancer: overview of essential pathways and somatic mutations in cancer progression

in Molecular and Cellular Oncology

Andrei-Alexandru Tirpe
Andreea Nutu
Constantin Busuioc
Ovidiu-Laurean Pop
Ioana Berindan-Neagoe

Frontiers in Oncology

doi 10.3389/fonc.2025.1677471

2,151 views
1 citation

Mini Review

Published on 07 Oct 2025

Context-dependent rewiring of dual-function proteins in cancer: a sequential strategy to restore apoptosis

in Molecular and Cellular Oncology

Leon Strzadala

Frontiers in Oncology

doi 10.3389/fonc.2025.1675537

1,803 views

Original Research

Published on 03 Oct 2025

Next-generation sequencing-based genomic profiling of advanced soft tissue and bone sarcomas

in Molecular and Cellular Oncology

Yasemin Gündoğdu
Elif Şenocak Taşçı
Leyla Özer
Can Boynukara
Recep Çeçen
Arda Ulaş Mutlu
İbrahim Yıldız

Frontiers in Oncology

doi 10.3389/fonc.2025.1627452

2,658 views
1 citation

Correction

Published on 03 Oct 2025

Correction: MiR-29b-3p inhibits migration and invasion of papillary thyroid carcinoma by down-regulating COL1A1 and COL5A1

in Molecular and Cellular Oncology

Congjun Wang
Ye Wang
Zhao Fu
Weijia Huang
Zhu Yu
Jiancheng Wang
Kaitian Zheng
Siwen Zhang
Shen Li
Junqiang Chen

Frontiers in Oncology

doi 10.3389/fonc.2025.1657780

1,355 views

Original Research

Published on 03 Oct 2025

The mutational landscape and actionable targets of gallbladder cancer: an ancestry-informed and comparative analysis of a Chilean population

in Molecular and Cellular Oncology

José Ignacio Erices
Evelin González
Marcela Salgado
Carol Barahona-Ponce
Matías Freire
Gonzalo Sepúlveda-Hermosilla
Diego Ampuero
Alejandro Blanco
Valentina Gárate-Calderón
Pablo Báez-Benavides

Frontiers in Oncology

doi 10.3389/fonc.2025.1658528

1,939 views
1 citation

Retraction

Published on 02 Oct 2025

Retraction: The biological functions and related signaling pathways of SPON2

in Molecular and Cellular Oncology

Frontiers in Oncology

doi 10.3389/fonc.2025.1712876

1,165 views

Review

Published on 25 Sep 2025

The potential role of PIWI-interacting RNAs in non-small cell lung cancer

in Molecular and Cellular Oncology

Linqian Song
Jian-Guo Zhou
Hu Ma

Frontiers in Oncology

doi 10.3389/fonc.2025.1660236

1,680 views

Review

Published on 24 Sep 2025

Merkel cell polyomavirus in lung carcinogenesis: evidence and controversy

in Molecular and Cellular Oncology

Changlong Zhou
Liang Lu
Maohong Hu
Tetsuro Suzuki
Xianfeng Zhou

Frontiers in Oncology

doi 10.3389/fonc.2025.1612605

1,823 views

Original Research

Published on 22 Sep 2025

Gallic acid potentiates the anticancer efficacy of cisplatin in ovarian cancer cells through modulation of the PI3K/AKT/mTOR and CXCL12/CXCR4 signaling pathways

in Molecular and Cellular Oncology

Jinlan Liang
Tingting Lu
Tiyan Shan
HuiTing Liang
Wenjie Wang
Zhijun Song
Yong Tang
Qi Wang

Frontiers in Oncology

doi 10.3389/fonc.2025.1653538

1,812 views
1 citation

Systematic Review

Published on 18 Sep 2025

Cell-free HPV-DNA as a high-accuracy biomarker for treatment de-escalation in HPV-positive head and neck squamous cell carcinoma

in Molecular and Cellular Oncology

Alex Hollander
Taichiro Nonaka

Frontiers in Oncology

doi 10.3389/fonc.2025.1569877

1,972 views

Review

Published on 16 Sep 2025

The paradoxical role of stem cells in osteosarcoma: from pathogenesis to therapeutic breakthroughs

in Molecular and Cellular Oncology

Zhengbing Su
Xiang Fang
Hong Duan

Frontiers in Oncology

doi 10.3389/fonc.2025.1643491

4,143 views
1 citation

Review

Published on 16 Sep 2025

Bibliometrics and scientometrics analysis of exosomes relevance in hepatocellular carcinoma (2014-2024)

in Molecular and Cellular Oncology

Kaikui Wu
Guiya Lu
Ruijun Guo
Chunxia Li
Minglin Ou

Frontiers in Oncology

doi 10.3389/fonc.2025.1614484

1,791 views

Review

Published on 16 Sep 2025

IQGAP1: cross-disease target via receptor-pathway networks

in Molecular and Cellular Oncology

Shaopeng Zhu
Yunpeng Zou
Jie Guo
Wenqi Ma
Laitong Lu
Ronghan Liu
Jianning Kang
Kai Zhao
Jiangbo Zhong

Frontiers in Oncology

doi 10.3389/fonc.2025.1632060

1,483 views

Original Research

Published on 15 Sep 2025

Histologic grade and STAS as key predictors of distant recurrence in resected early-stage lung adenocarcinoma: a single-center study

in Molecular and Cellular Oncology

Alessandro Bonis
Giulia Pagliarini
Giovanni Maria Comacchio
Marco Mammana
Federica Pezzuto
Vincenzo Verzeletti
Enrica Pellizzer
Alessandro Berni
Stefano Silvestrin
Giorgio Cannone

Frontiers in Oncology

doi 10.3389/fonc.2025.1626863

1,364 views

Original Research

Published on 11 Sep 2025

Circulating tumor DNA to anticipate loco-regional recurrence in early-stage breast cancer: a proof-of-concept study

in Molecular and Cellular Oncology

Valentina Appierto
Elena Tamborini
Paola Tiberio
Adele Busico
Loris De Cecco
Marco Silvestri
Cinzia De Marco
Elena Cavadini
Maria Carmen De Santis
Secondo Folli

Frontiers in Oncology

doi 10.3389/fonc.2025.1621322

2,850 views

Review

Published on 10 Sep 2025

The progress of miR-205 regulating apoptosis in cancer

in Molecular and Cellular Oncology

Dandan Chai
Hua Du
Yingxu Shi

Frontiers in Oncology

doi 10.3389/fonc.2025.1532659

1,723 views
1 citation

Original Research

Published on 10 Sep 2025

NEK4 suppresses cell proliferation in BT20 triple-negative breast cancer cells by diminishing expression of cell cycle genes, while its depletion mitigates proliferation in other cell lines

in Molecular and Cellular Oncology

Rashmi R. Joshi
E. Gloria Sepulveda
F. Ester Lujan
Jacob M. DeVargas
Amanda K. Ashley

Frontiers in Oncology

doi 10.3389/fonc.2025.1547899

1,798 views
1 citation

Editorial

Published on 09 Sep 2025

Editorial: Formation of immunological niches in tumor microenvironments: mechanisms and therapeutic potential

in Molecular and Cellular Oncology

Zilu Chen
Qingyu Luo
Weiling Li
Ying Luo
Xiaosheng Tan

Frontiers in Oncology

doi 10.3389/fonc.2025.1675697

1,146 views

Original Research

Published on 08 Sep 2025

Identification of MAEA protein as a potential target for chemoresistance in osteosarcoma using bioinformatics and proteomic analysis

in Molecular and Cellular Oncology

Chen Zhang
Ruizhen Wang
Xin Yi
Wannian Wang
Jing Yang
Lihua Zhang
Guibin Wang
Wei Wang

Frontiers in Oncology

doi 10.3389/fonc.2025.1597750

1,673 views

Editorial

Published on 05 Sep 2025

Editorial: Molecular mechanisms and treatment of MYCN-driven tumors, volume II

in Molecular and Cellular Oncology

Yuyan Zhu
Yusuke Suenaga

Frontiers in Oncology

doi 10.3389/fonc.2025.1690803

1,121 views

3,127 articles

articles

An early-stage 3D fibroblast-featured tumor model mimics the gene expression of the naïve tumor microenvironment, including genes involved in cancer progression and drug resistance

Improving Radiation Therapy Efficacy Considering DNA Repair, TP53 Mutations, Microscopic Heterogeneity and Low & High Dose Apoptosis

Long noncoding RNAs involved in therapeutic response: implications for cervical cancer drug resistance

Editorial: Interplay of immunity and ECM in cancer

MicroRNAs and lung cancer: overview of essential pathways and somatic mutations in cancer progression

Context-dependent rewiring of dual-function proteins in cancer: a sequential strategy to restore apoptosis

Next-generation sequencing-based genomic profiling of advanced soft tissue and bone sarcomas

Correction: MiR-29b-3p inhibits migration and invasion of papillary thyroid carcinoma by down-regulating COL1A1 and COL5A1

The mutational landscape and actionable targets of gallbladder cancer: an ancestry-informed and comparative analysis of a Chilean population

Retraction: The biological functions and related signaling pathways of SPON2

The potential role of PIWI-interacting RNAs in non-small cell lung cancer

Merkel cell polyomavirus in lung carcinogenesis: evidence and controversy

Gallic acid potentiates the anticancer efficacy of cisplatin in ovarian cancer cells through modulation of the PI3K/AKT/mTOR and CXCL12/CXCR4 signaling pathways

Cell-free HPV-DNA as a high-accuracy biomarker for treatment de-escalation in HPV-positive head and neck squamous cell carcinoma

The paradoxical role of stem cells in osteosarcoma: from pathogenesis to therapeutic breakthroughs

Bibliometrics and scientometrics analysis of exosomes relevance in hepatocellular carcinoma (2014-2024)

IQGAP1: cross-disease target via receptor-pathway networks

Histologic grade and STAS as key predictors of distant recurrence in resected early-stage lung adenocarcinoma: a single-center study

Circulating tumor DNA to anticipate loco-regional recurrence in early-stage breast cancer: a proof-of-concept study

The progress of miR-205 regulating apoptosis in cancer

NEK4 suppresses cell proliferation in BT20 triple-negative breast cancer cells by diminishing expression of cell cycle genes, while its depletion mitigates proliferation in other cell lines

Editorial: Formation of immunological niches in tumor microenvironments: mechanisms and therapeutic potential

Identification of MAEA protein as a potential target for chemoresistance in osteosarcoma using bioinformatics and proteomic analysis

Editorial: Molecular mechanisms and treatment of MYCN-driven tumors, volume II