Frontiers in Pharmacology | Drug Metabolism and Transport

Clinical Trial

Published on 02 Jun 2025

Safety, tolerability, pharmacokinetics, and pharmacodynamics of etrasimod in healthy Chinese adults: a randomized, double-blind, placebo-controlled dose-escalation phase 1 study

in Drug Metabolism and Transport

Fangfang Wang
Xiaoye Niu
Na Liu
Zhengying Zhu
Yun Lin
Lisa Ying
Haiyan Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1523339

122 views

Review

Accepted on 30 May 2025

A comprehensive overview of Triptolide utilizing nanotechnology and its potential applications in prostate diseases

in Drug Metabolism and Transport

Yiao Wang
Zhiyan Hou
Pan Song
Puze Wang
Jinze Li
Jing Zheng
Dong Lv

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1592066

Original Research

Published on 30 May 2025

Integrated UPLC–MS/MS and UPLC–Q–TOF–MS/MS analysis to reveal pharmacokinetics, tissue distribution, metabolism, and excretion of sipeimine in rats

in Drug Metabolism and Transport

Hui Zong
Chongyang Wang
Dongdong He
Liting Liu
Juanjuan Wan
Guodong Wang
Dingtao Li
Jun Ran
Meiling Zhang
Hui Tang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1595731

227 views

Original Research

Published on 30 May 2025

Chinese population may require further venetoclax dose reduction beyond guidelines when combined with voriconazole: real-world evidence from China

in Drug Metabolism and Transport

Rongrong Wang
Yanfen Li
Ran Zhang
Yuan Ren
Yifan Liu
Tianlin Wang
Jin Wu
Xiangjin Zheng
Shu Li
Yu Jing

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1539233

163 views

Clinical Trial

Published on 30 May 2025

The food effect on the pharmacokinetics of TQB3616 capsule in Chinse healthy subjects: a randomized, open-label, single-center, two-period, two-sequence crossover phase I clinical trial

in Drug Metabolism and Transport

Jun Dai
Yanan Zhou
Lei Zhang
Qing Ren
Zhengzhi Liu
Yanli Wang
Yang Cheng
Qiaohuan Deng
Haimiao Yang
Hong Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1586368

116 views

Review

Accepted on 27 May 2025

Ferroptosis as a potential therapeutic target for obesity-related metabolic diseases

in Drug Metabolism and Transport

Chaodong Huang
Tao Luo
HUA ZHANG
Linhui Cheng
Shuhong Peng
Xiaowei Zhou
Lan Cao
Fangyou Chen
Junwei He
Chen Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1581632

192 views

Original Research

Accepted on 27 May 2025

Impact of administration route and gene polymorphisms on the serum concentration of voriconazole among Chinese patients with hematologic malignancies

in Drug Metabolism and Transport

Zhiyao Chen
Menghua Zhang
Lin Wang
Yuzhu Cheng
Liyan Miao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1445583

191 views

Original Research

Accepted on 26 May 2025

Mechanistic Insights into the PAI-1 Inhibitor PAItrap3: Enhancing Lipid Metabolism in Adipose Tissue of Diabetic db/db Mice

in Drug Metabolism and Transport

Wang Lijing
Wang Linxi
Zhang zhouyangyang
Lin Menhua
Qi Liqin
Liu Libin
Zhuo Chen
Tang Shuzhi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1596655

123 views

Original Research

Published on 26 May 2025

Bioanalytical assay for the quantification of rucaparib in rat plasma using UPLC-MS/MS: development, and validation for interaction with myricetin

in Drug Metabolism and Transport

Jingjing Nie
Hailun Xia
Jie Chen
Jun Wu
Jinming Yang
Xuegu Xu
Congrong Tang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1576131

255 views

Original Research

Published on 23 May 2025

Pharmacokinetic and pharmacodynamic analyses of nafamostat in ECMO patients: comparing central vein and ECMO machine samples

in Drug Metabolism and Transport

Dong Hwan Lee
Jae Ha Lee
Ji Hoon Jang
Yong Kyun Kim
Gaeun Kang
So Young Jung
Minyoung Her
Hang Jea Jang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1541131

379 views

Original Research

Published on 21 May 2025

Serum retinol binding protein as a novel marker for clearance and dosage optimization: pharmacokinetics study of voriconazole in a cirrhosis population

in Drug Metabolism and Transport

Juping Yun
Haihong Bai
Zihe Wang
Yingmin Ma
Wei Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1543323

283 views

Review

Accepted on 19 May 2025

Cannabinoids and the endocannabinoid system in the regulation of cytochrome P450 metabolic activity-a review

in Drug Metabolism and Transport

Carlos Daniel Ferreira Fonseca
Ondřej Zendulka
Jan Juřica

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1599012

149 views

Original Research

Accepted on 19 May 2025

Pulmonary delivery of excipient-free tobramycin DPIs for the treatment of Pseudomonas aeruginosa lung infection with CF

in Drug Metabolism and Transport

Song Cheng
Haozhou Huang
Zhihao Zhang
Yulong Zhang
Mengxing Lin
Gang Yang
Lynda Thubelihle Kanye
Qingzhen Zhang
Ning Xue
Kaiqi Shi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1528905

135 views

Original Research

Published on 19 May 2025

Population pharmacokinetics of high-dose methotrexate in patients with primary central nervous system lymphoma

in Drug Metabolism and Transport

Shifeng Wei
Sitian Zhang
Dan Wang
Dongjie Zhang
Qian Lu
Jiayi Mo
Zhilin Yang
Leyi Guan
Yingjun He
Zhigang Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1578033

391 views

Original Research

Published on 19 May 2025

Liquid chromatography–tandem mass spectrometry assay for the simultaneous determination of apalutamide and its active metabolite N-desmethyl apalutamide, and its application in real-world patients with castration-resistant prostate cancer

in Drug Metabolism and Transport

Yuxuan Zhu
Lu Chen
Wenqiang Cheng
Dingyuan Yang
Lijuan Zhang
Jun Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1510583

486 views

Brief Research Report

Published on 19 May 2025

Study of genetic polymorphisms and steady-state trough concentrations of imatinib and its active metabolite in predicting efficacy in gastrointestinal stromal tumors

in Drug Metabolism and Transport

Menghua Zhang
Zhiyao Chen
Xiaoxue Liu
Xiaojun Zhou
Liyan Miao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1604619

399 views