Frontiers in Pharmacology | Drug Metabolism and Transport

Editorial

Published on 12 Nov 2025

Editorial: Non-invasive methods in drug metabolism and transport: insights from biological samples to oral administration

in Drug Metabolism and Transport

Karol Wróblewski
Yi Zheng
Xuyi Yue

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1735743

Mini Review

Published on 12 Nov 2025

Concerns from bench and insights from bedside: the puzzle of Roxadustat in cancer patients with chemotherapy-induced anemia

in Drug Metabolism and Transport

Lin Chen
Shigen Liao
Dan Jing
Linxiu Mao
Jing Tan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1703424

143 views

Mini Review

Accepted on 11 Nov 2025

Overcoming the Blood-Brain Barrier: Targeted Delivery Strategies for Gliomas

in Drug Metabolism and Transport

Xue Du
Chunbao Chen
Yijun Zeng
Zhimei Lin

Frontiers in Pharmacology

Original Research

Accepted on 10 Nov 2025

Biotransformation and kinetics of selected benzimidazole synthetic opioids in human hepatocytes

in Drug Metabolism and Transport

Pius S Fasinu
Gajanan Jadhav

Frontiers in Pharmacology

Clinical Trial

Published on 10 Nov 2025

Pharmacokinetics, mass balance, and metabolism of the novel potassium-competitive acid blocker JP-1366 in healthy Chinese adults following a single oral dose of [14C]JP-1366

in Drug Metabolism and Transport

Xuemei Liu
Decheng Deng
Jian Meng
Haitang Hu
Quankun Zhuang
Xue Zhou
Long Fu
Binke Fan
Xueting Xu
Qin Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1701581

276 views

Original Research

Accepted on 07 Nov 2025

Nonclinical evaluation of HS630, a proposed biosimilar of Trastuzumab Emtansine: Affinity, pharmacokinetics, and immunogenicity

in Drug Metabolism and Transport

Hui Jiang
Jinjing Che

Frontiers in Pharmacology

Clinical Trial

Published on 07 Nov 2025

Evaluation of the pharmacokinetics, pharmacodynamics, and liver ultrasound imaging characteristics of a novel perfluoropropane microbubble in Chinese volunteers

in Drug Metabolism and Transport

Pengfei Li
Ping Du
Zhixia Zhao
Fei Jia
Weiyue Yu
Peng Qu
Jiangfan Li
Xuhong Wang
Lihong Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1704972

307 views

Mini Review

Accepted on 06 Nov 2025

Small RNA or oligonucleotide drugs and challenges in evaluating drug-drug interactions

in Drug Metabolism and Transport

Joseph M. Cronin
Aiming Yu

Frontiers in Pharmacology

126 views

Original Research

Accepted on 06 Nov 2025

Endogenous Tetrahydrobiopterin in Humans: Circadian Rhythm, Sex, Race, Age, and Disease Status

in Drug Metabolism and Transport

Lan Gao
Neil Smith
Ronald Kong

Frontiers in Pharmacology

Original Research

Published on 06 Nov 2025

Low-dose methotrexate adverse reaction risk in renal impairment: pharmacovigilance and physiological pharmacokinetic model assessment

in Drug Metabolism and Transport

Lichang Zhang
Jianling Li
Xin Wang
Yaolei Zhang
Sen Gao
Deshi Dong
Yanna Zhu
Shilei Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1703557

595 views

Original Research

Accepted on 03 Nov 2025

Development of an In Vitro Metabolic Dysfunction-Associated Steatohepatitis Model to Investigate Altered Drug Metabolizing Enzymes, Transport Proteins, and Hepatobiliary Disposition

in Drug Metabolism and Transport

William Alan Murphy
Sarina Kyburz
Henry Ho
Matthew Shane Loop
John K Fallon
Jacqueline B Tiley
Thomas Kralj
Kim L.R. Brouwer

Frontiers in Pharmacology

179 views

Original Research

Accepted on 31 Oct 2025

Preclinical pharmacokinetic characterization of (R)-ketamine injection,a novel antidepressant glutamatergic agent

in Drug Metabolism and Transport

Rui Wang
Yongchao Jin
Bingjie Zou
Li Ding

Frontiers in Pharmacology

236 views

Clinical Trial

Accepted on 31 Oct 2025

Bioequivalence of a Single Dose of Two Palbociclib Formulations in Healthy Chinese Subjects Under Fasting Conditions: A Two-Period Crossover Study with Rabeprazole Pre-treatment

in Drug Metabolism and Transport

Wanjun Bai
Shuo Shi
Deliang Yin
Caihui Guo
Haojing Song
Yiting Hu
Jin Gao
Bo Qiu
Xueyuan Zhang
Lusha Bi

Frontiers in Pharmacology

221 views

Original Research

Accepted on 27 Oct 2025

Pharmacokinetics of mycophenolic acid in plasma and peripheral blood mononuclear cells and its relationship with activity of inosine-5′-monophosphate dehydrogenase in Chinese adult kidney allograft recipients

in Drug Metabolism and Transport

Yun-Zhu Lu
Lu Xiaoling
Jiaqian LU
Kun Shao
Hui-Min An
Pei-Jun Zhou
Hao-Qiang Shi
Bing Chen

Frontiers in Pharmacology

138 views

Original Research

Accepted on 27 Oct 2025

Changed expression of placental transporters and disrupted epigenetic patterns in a rat model of schizophrenia

in Drug Metabolism and Transport

Péter Szatmári
Adrienn Seres-Bokor
Anita Sztojkov-Ivanov
Gabriella Kekesi
Gyöngyi Horvath
Eszter Ducza

Frontiers in Pharmacology

182 views

Review

Published on 27 Oct 2025

Strategy advancements in placental pharmacokinetics: from in vitro experiments to in silico prediction

in Drug Metabolism and Transport

Zhimin Li
Yue Wu
Siyu Zeng
Fei Wang
Jiao Zhang
Shiran Li
Yong Yang
Yujie Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1694886

481 views