Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Accepted on 30 May 2025

Innovative pH-responsive alginate-coated rosuvastatin-loaded chitosan nanoparticles: A targeted approach to inhibiting HMGB1-activated RAGE/TLR4-NFκB signaling in colonic inflammation in rats

in Experimental Pharmacology and Drug Discovery

Elsayed A Elmorsy
Sameh Saber
Zubida M Al-Majdoub
Rabab S Hamad
Mustafa Ahmed Abdel-Reheim
Asmaa Ramadan
Norah Suliman Alsoqih
Mariam S Alharbi
Hamad Alsaykhan
Alshaimaa A Farrag

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1546010

Review

Accepted on 30 May 2025

Lactate-induced lactylation: from basic research to clinical perspectives Authors

in Experimental Pharmacology and Drug Discovery

henghe shi
Yifei Zou
Sijie Jin
Junduo Wu
Bin Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1586973

Original Research

Accepted on 30 May 2025

Modified Zexie Decoction Improves Phlegm-Dampness Type Stage I Hypertension by Regulating the Gut-Immune-Kidney Axis

in Experimental Pharmacology and Drug Discovery

Zeqi Hu
Jiujie Jia
Yiyan Su
Yihao Gu
Bingbing Cheng
Ninghua Jiang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1578815

Original Research

Accepted on 30 May 2025

KU124 (9,10,10-trioxo-N-(2-phenylphenyl)thioxanthene-3-carboxamide) as a novel inhibitor of TASK-1

in Experimental Pharmacology and Drug Discovery

Ana Dumani
Annette Jocob
Diego Chavez
Abena Amankwaa
Ramish Zahed
Martha Julemis
Hinaben Patel
Joana Lopez
Steven Almazan
Patrick Martins

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1577171

Original Research

Published on 30 May 2025

Protective effects of shikimic acid against thioacetamide-induced hepatic fibrosis: role of Nrf2/NF-κB signaling pathways

in Experimental Pharmacology and Drug Discovery

Ashraf Albrakati

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1609711

168 views

Original Research

Published on 30 May 2025

Enhanced resistance to Listeria infection in mice surviving sepsis: the role of lipid metabolism and myeloid cell reprogramming

in Experimental Pharmacology and Drug Discovery

Haruki Watanabe
Tengfei Song
Jaewoo Choi
Moses Lee
Kwangmin Choi
Junhwan Kim
Barbara Sherry
Betty Diamond
Yong-Rui Zou
Myoungsun Son

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1588987

169 views

Original Research

Published on 30 May 2025

Ursolic acid drug-drug nanocrystals ameliorate cholestatic liver injury via inhibiting oxidative stress and regulating bile acid metabolism

in Experimental Pharmacology and Drug Discovery

Manhang Hu
Xiaolu Hua
Wei Xiong
Enhui Zheng
Xingyue Yang
Yu Lu
Bing He
Xiaolin Zhong
Zongzhe Jiang
Qingbi Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1586141

149 views

Original Research

Published on 30 May 2025

Network-based analysis and experimental validation of identified natural compounds from Yinchen Wuling San for acute myeloid leukemia

in Experimental Pharmacology and Drug Discovery

Biyu Zhang
Denggang Fu
Xin Wang
Xuelei Hu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1591164

147 views

Original Research

Published on 30 May 2025

Perfusion pressure as a determinant of respiratory function outcomes in unilateral biportal lumbar endoscopic procedures

in Experimental Pharmacology and Drug Discovery

Liang Zhang
Han Zheng
Yan Fu
Wenbo Li
Jianlong Lang
Yi Wang
Weibin Ren

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1593118

216 views

Original Research

Published on 30 May 2025

7-α-O-Methylmorroniside ameliorated brain injury in 5×FAD mice by regulating the gut microbiome and NMDAR2B

in Experimental Pharmacology and Drug Discovery

Fengxiao Hao
Mengnan Zeng
Bing Cao
Xiwen Liang
Zhiyou Hao
Kaili Ye
Xinmian Jiao
Weisheng Feng
Xiaoke Zheng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1545566

143 views

Original Research

Published on 30 May 2025

Vitexicarpin suppresses colorectal and non-small cell lung cancer via selective inhibition of Anoctamin 1

in Experimental Pharmacology and Drug Discovery

Yohan Seo
Sion Lee
Raju Das
Sung Baek Jeong
Chul Soon Park
Minuk Kim
Deok Kyu Yoon
Armin Sultana
Kantu Das
Jae-Eon Lee

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1557193

Original Research

Published on 30 May 2025

Multimodal endovascular management of traumatic carotid-cavernous fistulas: case series and lessons learned

in Experimental Pharmacology and Drug Discovery

Shangdi Yang
Richao Chen
Mingjia Yi
Chuangnan Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1602971

Correction

Accepted on 29 May 2025

Corrigendum:A telomere-related signature for predicting prognosis and immune microenvironment of osteosarcoma

in Experimental Pharmacology and Drug Discovery

Shihao Li
Lina Zhang
Haiyang Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1600217

102 views

Review

Accepted on 29 May 2025

Potential of Functional Flavonoids in Targeting Vasospasm through Modulation of Oxidative Stress and SPC-induced Signaling Pathways

in Experimental Pharmacology and Drug Discovery

YING ZHANG
Sho Maejima
Kentaro Matsuzaki
Hiroko Kishi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1594060

Correction

Accepted on 29 May 2025

Neuroprotective effects of a novel peptide through the Rho-integrin-Tie2 and PI3K/Akt pathways in experimental autoimmune encephalomyelitis model

in Experimental Pharmacology and Drug Discovery

Wen Zhou
Han Qu
Xiao-Xiao Fu
Miao-Miao Xu
Qiang Li
Yuan Jiang
Shu Han

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1611105

101 views

Original Research

Published on 29 May 2025

Deep learning-based action recognition for analyzing drug-induced bone remodeling mechanisms

in Experimental Pharmacology and Drug Discovery

Li Qinsheng
Li Ming
Li Yuening
Zhao Xiufeng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1564157

207 views