Frontiers in Toxicology

Review

Published on 19 Sep 2025

Environmental exposure pathways of microplastics and their toxic effects on ecosystems and the nervous system

in Neurotoxicology

Kuo Lu
Yixiang Que
Longfei Wang
Yanfan Wang
Jinyan Qiu
Yangyang Jia
Cong Ding
Dazhong Wang
Weyland Cheng
Yaodong Zhang

Frontiers in Toxicology

doi 10.3389/ftox.2025.1649282

3,940 views
1 citation

Original Research

Published on 15 Sep 2025

Daflon and Centrum mitigate vancomycin-induced nephrotoxicity in rats by ameliorating oxidative stress, DNA damage, apoptosis, and inflammation

in Clinical Toxicology

Hanem F. El-Gendy
Soaad Salamah
Eman Elhusseiny
Hazim O. Khalifa
Hossny A. El-Banna
Taha A. Attia
Shaimaa Selim
Saber El Hanbally

Frontiers in Toxicology

doi 10.3389/ftox.2025.1673083

1,669 views

Original Research

Published on 15 Sep 2025

Error-corrected next-generation sequencing mutagenicity assays in human HepaRG cells as human-relevant genetic toxicology new approach methodology

in Regulatory Toxicology

A. Rasim Barutcu
Nimisha Bhattarai
Raymond Samuel
Jamie Scaglione
Leslie Recio

Frontiers in Toxicology

doi 10.3389/ftox.2025.1657189

2,548 views
1 citation

Review

Published on 09 Sep 2025

Antibody-based alternatives to animal testing for toxin detection and antitoxin evaluation

in In Vitro Toxicology

Seo-Hyuk Chang
Jieun Jang
Wonjun Yang
Nam-Kyung Lee
Seoyeon Choi
Hyo-Il Jung
Wantae Kim
Boksik Cha
Sung-Jin Yoon
Ji-Yoon Noh

Frontiers in Toxicology

doi 10.3389/ftox.2025.1636246

3,309 views

Case Report

Published on 09 Sep 2025

Mercury exposure leading to functional vitamin B12 deficiency and subacute combined degeneration: a case report and literature review

in Occupational Toxicology

Isidora Semnic
Valentino Rački
Olivia Perković
Vladimira Vuletić

Frontiers in Toxicology

doi 10.3389/ftox.2025.1580275

3,274 views

Original Research

Published on 08 Sep 2025

Occupational exposure and its mechanistic link to allergic asthma and lung function decline; a data-driven approach coupled to mining of adverse outcome pathway signatures

in Occupational Toxicology

Rob Stierum
Manosij Ghosh
Marjolein Meijerink
Xavier Pinho
Joost Westerhout
Vivi Schlünssen
Anjoeka Pronk
Jolanda van Bilsen

Frontiers in Toxicology

doi 10.3389/ftox.2025.1589380

1,948 views

Original Research

Published on 03 Sep 2025

Exploring plasticisers-osteoporosis links and mechanisms: a cohort and network toxicology study

in Environmental Toxicology

Xingyao Yang
Xin Wang
Shifu Bao
Zhengjiang Li
Shuxing Xing
Zhangzhen Du

Frontiers in Toxicology

doi 10.3389/ftox.2025.1617663

3,375 views

Review

Published on 29 Aug 2025

The impact of perfumes and cosmetic products on human health: a narrative review

in Environmental Toxicology

Sharifa Alblooshi

Frontiers in Toxicology

doi 10.3389/ftox.2025.1646075

15,604 views
2 citations

Systematic Review

Published on 25 Aug 2025

Stroke risk following bee and wasp stings: a systematic review of ischemic and hemorrhagic events

in Clinical Toxicology

Jorge Vasconez-Gonzalez
Juan S. Izquierdo-Condoy
Karen Delgado-Moreira
María de Lourdes Noboa-Lasso
Esteban Gamez-Rivera
Camila Salazar-Santoliva
María Belén Lopez-Molina
Esteban Ortiz-Prado

Frontiers in Toxicology

doi 10.3389/ftox.2025.1632308

3,776 views

Original Research

Published on 21 Aug 2025

Integral approach to organelle profiling in human iPSC-derived cardiomyocytes enhances in vitro cardiac safety classification of known cardiotoxic compounds

in In Vitro Toxicology

Brigitta R. Szabo
Jeroen Stein
Anna Savchenko
Thomas Hutschalik
Filip Van Nieuwerburgh
Tim Meese
Georgios Kosmidis
Paul G. A. Volders
Elena Matsa

Frontiers in Toxicology

doi 10.3389/ftox.2025.1644119

2,502 views

Hypothesis and Theory

Published on 21 Aug 2025

Determining a NOAEL for the consortium linking academic and regulatory insights on BPA toxicity (CLARITY-BPA) core study

in Developmental and Reproductive Toxicology

Melissa Badding
Noor Aly
Kevin Sondenheimer

Frontiers in Toxicology

doi 10.3389/ftox.2025.1639737

1,964 views

Original Research

Published on 18 Aug 2025

Validation of a novel questionnaire for assessing occupational exposure to organophosphate pesticides in Chilean agricultural workers

in Occupational Toxicology

Liliana Zúñiga-Venegas
Natalia Landeros
Floria Pancetti
Sandra Cortés
Boris Lucero
Ana M. Brito
Ian S. Acuña-Rodríguez
María Teresa Muñoz-Quezada

Frontiers in Toxicology

doi 10.3389/ftox.2025.1588408

2,115 views
1 citation

Perspective

Published on 11 Aug 2025

Uncovering exposome-related diseases through the pathologic metallome: a novel approach for clinical populations

in Occupational Toxicology

Riccardo Leinardi
François Huaux

Frontiers in Toxicology

doi 10.3389/ftox.2025.1625874

1,763 views

Original Research

Published on 11 Aug 2025

Assessment of heated herbal products’ tobacco harm reduction potential: pre‐clinical and clinical studies

in Regulatory Toxicology

Alvaro-Flavio Marinas-Lacasta
Ian M. Fearon
Matthew Stevenson
Tasnim Abusalem
Fiona Chapman
Edgar Trelles Sticken
Roman Wieczorek
Sarah Jean Pour
Ole Dethloff
Ourania Komini

Frontiers in Toxicology

doi 10.3389/ftox.2025.1589480

4,563 views

Review

Published on 08 Aug 2025

Fetal bovine serum: how to leave it behind in the pursuit of more reliable science

in In Vitro Toxicology

Tilo Weber
Atena Malakpour-Permlid
Aline Chary
Vito D’Alessandro
Leah Haut
Sebastian Seufert
Esther Veronika Wenzel
James Hickman
Karen Bieback
Joachim Wiest

Frontiers in Toxicology

doi 10.3389/ftox.2025.1612903

11,308 views
11 citations

Original Research

Published on 06 Aug 2025

Epidemiological investigation of venomous snakebites in Yunnan Province

in Clinical Toxicology

Qinfen Gao
Yajun Teng
Chao Xiao
Rui Zeng
Bin Han
Hong Gao
Jianhai Wang
Xiaoyan Li
Canju Yang
Jianneng Dai

Frontiers in Toxicology

doi 10.3389/ftox.2025.1609487

3,139 views
3 citations

Original Research

Published on 04 Aug 2025

Refinement of a workflow for human relevance assessment of adverse outcome pathways and associated new approach methodologies

in Regulatory Toxicology

Annick D. van den Brand
Julia J. Meerman
Christina H. J. Veltman
Mirjam Luijten

Frontiers in Toxicology

doi 10.3389/ftox.2025.1616817

2,025 views

Case Report

Published on 31 Jul 2025

Case Report: Successful management of severe suicidal lamotrigine overdose-induced status epilepticus with sustained low-efficiency dialysis

in Clinical Toxicology

Naoki Kawahara
Hiroki Matsui
Koji Morishita

Frontiers in Toxicology

doi 10.3389/ftox.2025.1622752

7,307 views
1 citation

Original Research

Published on 30 Jul 2025

Research on the impact of graphene oxide in feed on growth and health parameters in calves

in Food and Nutritional Toxicology

Tereza Aulichova
Sylvie Skalickova
Kopec Tomas
Pompido Chilala
Pavel Horky

Frontiers in Toxicology

doi 10.3389/ftox.2025.1560078

2,189 views
1 citation

Original Research

Published on 23 Jul 2025

Cadmium decreases human gingival fibroblast viability and induces pro-inflammatory response associated with Akt and MAPK pathway activation

in In Vitro Toxicology

Tipparat Parakaw
Sirada Srihirun
Nathawut Sibmooh
Nisarat Ruangsawasdi
Phisit Khemawoot
Pornpun Vivithanaporn

Frontiers in Toxicology

doi 10.3389/ftox.2025.1583865

2,512 views
1 citation

Original Research

Published on 22 Jul 2025

A deep-learning approach to predict reproductive toxicity of chemicals using communicative message passing neural network

in Computational Toxicology and Informatics

Owen He
Daoxing Chen
Yimei Li

Frontiers in Toxicology

doi 10.3389/ftox.2025.1640612

3,340 views
2 citations

Perspective

Published on 17 Jul 2025

Stress convulsions in rodents: within a weight-of-evidence framework for human seizure risk

in Regulatory Toxicology

Joseph J. DeGeorge
Monica R. Metea

Frontiers in Toxicology

doi 10.3389/ftox.2025.1600816

1,857 views

Original Research

Published on 15 Jul 2025

Chain length-dependent mitochondrial toxicity of perfluoroalkyl carboxylic acids: insights from Mito Tox Index evaluation

in Environmental Toxicology

Yoonseok Kam
Lisa Winer
Natalia Romero

Frontiers in Toxicology

doi 10.3389/ftox.2025.1582891

2,918 views
4 citations

Original Research

Published on 14 Jul 2025

Subchronic effects of HgCl2 on cognitive function and central inflammation in type 2 diabetic rats: involvement of BDNF and acetylcholinesterase

in Neurotoxicology

Douae Benloughmari
Samir Bikri
Meriam El Aboubi
Fatima-Zahra Yassif
Youssef Aboussaleh

Frontiers in Toxicology

doi 10.3389/ftox.2025.1610720

1,951 views

638 articles

articles

Environmental exposure pathways of microplastics and their toxic effects on ecosystems and the nervous system

Daflon and Centrum mitigate vancomycin-induced nephrotoxicity in rats by ameliorating oxidative stress, DNA damage, apoptosis, and inflammation

Error-corrected next-generation sequencing mutagenicity assays in human HepaRG cells as human-relevant genetic toxicology new approach methodology

Antibody-based alternatives to animal testing for toxin detection and antitoxin evaluation

Mercury exposure leading to functional vitamin B12 deficiency and subacute combined degeneration: a case report and literature review

Occupational exposure and its mechanistic link to allergic asthma and lung function decline; a data-driven approach coupled to mining of adverse outcome pathway signatures

Exploring plasticisers-osteoporosis links and mechanisms: a cohort and network toxicology study

The impact of perfumes and cosmetic products on human health: a narrative review

Stroke risk following bee and wasp stings: a systematic review of ischemic and hemorrhagic events

Integral approach to organelle profiling in human iPSC-derived cardiomyocytes enhances in vitro cardiac safety classification of known cardiotoxic compounds

Determining a NOAEL for the consortium linking academic and regulatory insights on BPA toxicity (CLARITY-BPA) core study

Validation of a novel questionnaire for assessing occupational exposure to organophosphate pesticides in Chilean agricultural workers

Uncovering exposome-related diseases through the pathologic metallome: a novel approach for clinical populations

Assessment of heated herbal products’ tobacco harm reduction potential: pre‐clinical and clinical studies

Fetal bovine serum: how to leave it behind in the pursuit of more reliable science

Epidemiological investigation of venomous snakebites in Yunnan Province

Refinement of a workflow for human relevance assessment of adverse outcome pathways and associated new approach methodologies

Case Report: Successful management of severe suicidal lamotrigine overdose-induced status epilepticus with sustained low-efficiency dialysis

Research on the impact of graphene oxide in feed on growth and health parameters in calves

Cadmium decreases human gingival fibroblast viability and induces pro-inflammatory response associated with Akt and MAPK pathway activation

A deep-learning approach to predict reproductive toxicity of chemicals using communicative message passing neural network

Stress convulsions in rodents: within a weight-of-evidence framework for human seizure risk

Chain length-dependent mitochondrial toxicity of perfluoroalkyl carboxylic acids: insights from Mito Tox Index evaluation

Subchronic effects of HgCl2 on cognitive function and central inflammation in type 2 diabetic rats: involvement of BDNF and acetylcholinesterase