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24 news posts in Immunology

Featured news

12 Sep 2019

Researchers identify cancer killing capability of lesser-known immune cells

Linked with obesity, esophageal cancer is one of the fastest growing cancers in the Western world. Image: Shutterstock. Finding new ways to reverse the inhibition of ‘MAIT’ immune cells could transform the prognosis of esophageal cancer — by Trinity College Dublin Researchers at Trinity College Dublin have identified, for the first time in esophageal cancer, the cancer killing capability of a lesser-known type of immune cell, presenting a new potential therapeutic target. Their research is published in Frontiers in Immunology. Esophageal cancer is a very aggressive type of cancer with poor prognosis, and the 5-year survival rate is typically less than 15%. Linked with obesity, esophageal cancer is one of the fastest growing cancers in the Western world and incidence is due to double in Ireland within the next few decades. Current treatment strategies work well but only for a minority (approx. 25%) of patients so new treatment options are urgently needed. New treatment strategies targeting the immune system have had revolutionary effects in other cancer types, but the latest clinical trials show that, disappointingly, immunotherapy offers no real benefit for the majority of patients with oesophageal cancer. Mucosal-Associated Invariant T Cells Display Diminished Effector Capacity in Oesophageal Adenocarcinoma► Read original […]

Luigi Daniele Notarangelo

Frontiers news

05 Jul 2016

Frontiers in Immunology: New Field Chief Editor takes the Helm

Frontiers announces the appointment of Professor Luigi Notarangelo, Boston Children’s Hospital, Harvard Medical School, as the new Field Chief Editor for Frontiers in Immunology, effective on July 13, 2016. Professor Luigi Notarangelo, a world renowned expert in primary immunodeficiencies, has agreed to expand his role in the Journal from his current function as Specialty Chief Editor of the Primary Immunodeficiency section of Frontiers in Immunology.  His numerous scientific achievements include the identification of gene defects that contribute to severe combined immune deficiencies (SCID) and the development of novel treatment for children severely affected by congenital immunodeficiencies. In addition to his scientific research, Professor Notarangelo plays an active role in many professional societies, including being the President of the European Society for Immune Deficiencies from 2002-2006 and of the Clinical Immunology Society in 2015-2016, and co-chairing the Committee on Primary Immunodeficiencies of the International Union of Immunological Societies (IUIS). We also thank our outgoing and founding Field Chief Editor for the Journal, Professor Kendall Smith from Weill Medical College of Cornell University for his years of service to the community. Publishing across 18 specialty sections, including such multidisciplinary subject areas as Cancer Immunity and Immunotherapy, Frontiers in Immunology now has over 2500 editors from top institutions all over […]

Impact analysis

03 Jul 2016

Quality and Impact Analysis: Frontiers in Immunology

Coming soon: 2017 analysis based on the most recent Journal Citation Reports by Clarivate Analytics (formerly published by Thomson Reuters). Frontiers in Immunology, launched in 2010, received its first official Impact Factor of 5.695 in 2016. In just 5 years, it became the largest and the most cited open-access journal in Immunology, and the 7th most cited among all journals in Immunology. Impact Factor (IF), defined as the total number of citations in a given year divided by the number of citable articles over the previous two-year period, is the most commonly accepted metric of journal quality (but not of an individual paper or researcher). It was formally established by the Institute for Scientific Information (ISI) in 1975. As the IF can be heavily skewed by a few highly-cited papers, total citations generated over the same two-year period provide a more accurate indication of the overall  influence or impact of the articles published by a journal in a field. Frontiers is a pioneer in the use of article-level and author-level metrics and encourages every author to use these to track the development of his or her readership on a more granular level. Analysis within the category of Immunology There are 150 journals listed in the category of Immunology in […]

Frontiers news

05 Jun 2016

Most viewed Immunology articles in May 2016

Toll-Like Receptor 2 Mediates In Vivo Pro- and Anti-inflammatory Effects of Mycobacterium Tuberculosis and Modulates Autoimmune Encephalomyelitis Alessia Piermattei, Giuseppe Migliara, Gabriele Di Sante, Maria Foti, Soren Bohos Hayrabedyan, Angela Papagna, Maria Concetta Geloso, Maddalena Corbi, Mariagrazia Valentini, Alessandro Sgambato, Giovanni Delogu, Gabriela Constantin and Francesco Ria* A Subset of Patients with Acute Myeloid Leukemia Has Leukemia Cells Characterized by Chemokine Responsiveness and Altered Expression of Transcriptional as well as Angiogenic Regulators Annette K. Brenner*, Håkon Reikvam and Øystein Bruserud CD4+ T-Cell-Independent Secondary Immune Responses to Pneumocystis Pneumonia Nicholas M. de la Rua, Derrick R. Samuelson, Tysheena P. Charles, David A. Welsh and Judd E. Shellito* Coupling of HIV-1 Antigen to the Selective Autophagy Receptor SQSTM1/p62 Promotes T-Cell-Mediated Immunity Aram Nikolai Andersen*, Ole Jørgen Landsverk, Anne Simonsen, Bjarne Bogen, Alexandre Corthay and Inger Øynebråten* Mathematical Model Reveals the Role of Memory CD8 T Cell Populations in Recall Responses to Influenza Veronika I. Zarnitsyna*, Andreas Handel, Sean R. McMaster, Sarah L. Hayward, Jacob E. Kohlmeier, and Rustom Antia* CD1c-Related DCs that Express CD207/Langerin, but Are Distinguishable from Langerhans Cells, Are Consistently Present in Human Tonsils Anne De Monte, Charles-Vivien Olivieri, Sébastien Vitale, Sonanda Bailleux, Laurent Castillo, Valérie Giordanengo, Janet L. Maryanski, Elodie Segura and Alain Doglio* Relevance […]

Frontiers news

07 May 2016

Most viewed Immunology articles in April 2016

Suppression of HIV Replication by CD8+ Regulatory T-Cells in Elite Controllers Wei Lu*, Song Chen, Chunhui Lai, Mingyue Lai, Hua Fang, Hong Dao, Jun Kang, Jianhua Fan, Weizhong Guo, Linchun Fu and Jean-Marie Andrieu* Microchip Screening Platform for Single Cell Assessment of NK Cell Cytotoxicity Karolin Guldevall, Ludwig Brandt, Elin Forslund, Karl Olofsson, Thomas W. Frisk, Per E. Olofsson, Karin Gustafsson, Otto Manneberg, Bruno Vanherberghen, Hjalmar Brismar, Klas Kärre, Michael Uhlin and Björn Önfelt* Intrinsic Contribution of Perforin to NK-Cell Homeostasis during Mouse Cytomegalovirus Infection Maja Arapović, Ilija Brizić, Branka Popović, Slaven Jurković, Stefan Jordan, Astrid Krmpotić, Jurica Arapović and Stipan Jonjić* A Multi-Component Prime-Boost Vaccination Regimen with a Consensus MOMP Antigen Enhances Chlamydia trachomatis Clearance Alexander Badamchi-Zadeh, Paul F. McKay, Bette T. Korber, Guillermo Barinaga, Adam A. Walters, Alexandra Nunes, João Paulo Gomes, Frank Follmann, John S. Tregoning and Robin J. Shattock* Tracking TCRβ Sequence Clonotype Expansions during Antiviral Therapy Using High-Throughput Sequencing of the Hypervariable Region Mark W. Robinson, Joseph Hughes, Gavin S. Wilkie, Rachael Swann, Stephen T. Barclay, Peter R. Mills, Arvind H. Patel, Emma C. Thomson* and John McLauchlan* PD1-Expressing T Cell Subsets Modify the Rejection Risk in Renal Transplant Patients Rebecca Pike, Niclas Thomas, Sarita Workman, Lyn Ambrose, David Guzman, Shivajanani […]

Life sciences

29 Apr 2016

Advancing immunology and primary immunodeficiencies in the genomic era: The importance of being collaborative

We celebrate the day of Immunology with an interview with Sergio Rosenzweig, Deputy Chief of the Immunology Service at the Clinical Center, NIH and the Co-Director of the Primary Immunodeficiency Clinic, NIAID, NIH and Associate Editor for Frontiers in Immunology and for Frontiers in Pediatrics. After more than 20 years of experience as pediatrician and researcher in the field of primary immunodeficiencies, Dr Rosenzweig has no doubt: the best is yet to come.  “It is a fascinating time to be practicing medicine: if you take into consideration that the first genome was sequenced in 2003 and just six years later, in 2009, the first patient that diagnosed using next-generation sequencing, with a test cost reduction of 1 million times (from approximately 1billion dollars to 1 thousand dollars, that is just amazing” he said. Through omics technologies, the field of primary immunodeficiencies field is evolving at an exponential rate “We discover, on average, more than one new gene associated with primary immunodeficiencies per month”, he explained, “and this is teaching us so much: we thought we knew about those diseases, but now we are completely rethinking the way we study them.”   Can you tell us a bit more about primary […]

Frontiers news

09 Apr 2016

Most viewed Immunology articles in March 2016

Hand to Mouth: A Systematic Review and Meta-Analysis of the Association between Rheumatoid Arthritis and Periodontitis Nicholas R. Fuggle, Toby O. Smith, Arvind Kaul, and Nidhi Sofat* Distinct Mechanisms Regulate Lck Spatial Organization in Activated T cells Natasha Kapoor-Kaushik, Elizabeth Hinde, Ewoud B. Compeer, Yui Yamamoto, Felix Kraus, Zhengmin Yang, Jieqiong Lou, Sophie V. Pageon, Thibault Tabarin, Katharina Gaus* and Jeremie Rossy* An Oral Salmonella-Based Vaccine Inhibits Liver Metastases by Promoting Tumor-Specific T-Cell-Mediated Immunity in Celiac and Portal Lymph Nodes: A Preclinical Study Alejandrina Vendrell*, Claudia Mongini, María José Gravisaco, Andrea Canellada, Agustina Inés Tesone, Juan Carlos Goin and Claudia Inés Waldner* Efficient mRNA-Based Genetic Engineering of Human NK Cells with High-Affinity CD16 and CCR7 Augments Rituximab-Induced ADCC against Lymphoma and Targets NK Cell Migration toward the Lymph Node-Associated Chemokine CCL19 Mattias Carlsten*, Emily Levy, Amrita Karambelkar, Linhong Li, Robert Reger, Maria Berg, Madhusudan V. Peshwa and Richard Childs Thioreductase-Containing Epitopes Inhibit the Development of Type 1 Diabetes in the NOD Mouse Model Elin Malek Abrahimians, Luc Vander Elst, Vincent A. Carlier and Jean-Marie Saint-Remy* miR-146a and miR-155 Expression Levels in Acute Graft-Versus-Host Disease Incidence Sadaf Atarod, Mohammed Mahid Ahmed, Clare Lendrem, Kim Frances Pearce, Wei Cope, Jean Norden, Xiao-Nong Wang, Matthew Collin and Anne Mary Dickinson* Potential […]

Frontiers news

06 Mar 2016

Most viewed Immunology articles in February 2016

Peracetic Acid Treatment Generates Potent Inactivated Oral Vaccines from a Broad Range of Culturable Bacterial Species Kathrin Moor, Sandra Y.  Wotzka, Albulena Toska, Médéric Diard, Siegfried Hapfelmeier and Emma Slack* Cytokines Induce Faster Membrane Diffusion of MHC Class I and the Ly49A Receptor in a Subpopulation of Natural Killer Cells Sunitha Bagawath-Singh, Elina Staaf, Arie Jan Stoppelenburg, Thiemo Spielmann, Taku Kambayashi, Jerker Widengren and Sofia Johansson* Evidence for Resident Memory T Cells in Rasmussen Encephalitis Geoffrey C. Owens*, Julia W. Chang, My N. Huynh, Thabiso Chirwa, Harry V. Vinters and Gary W. Mathern B Cells Negatively Regulate the Establishment of CD49b+T-bet+ Resting Memory T Helper Cells in the Bone Marrow Shintaro Hojyo, Jana Sarkander, Christian Maenne, Mathias Mursell, Asami Hanazawa, David Zimmel, Jinfang Zhu, William E. Paul, Simon Fillatreau, Max Löhning, Andreas Radbruch and Koji Tokoyoda* Expression of TLR-7, MyD88, NF-kB, and INF-α in B Lymphocytes of Mayan Women with Systemic Lupus Erythematosus in Mexico Guillermo Valencia Pacheco*, Irene B. Novelo Noh, Rubi M.-H.Velasco Cardenas, Angelica V. Angulo Ramirez, Ricardo F. Lopez Viallanueva, Irma G. Quintal Ortiz, Ligia G. Alonso Salomon, Norma Pavia Ruz and Nubia A. Rivero Cardenas The Non-structural Protein 5 and Matrix Protein Are Antigenic Targets of T Cell Immunity to Genotype 1 Porcine Reproductive […]