Impact Factor 3.678

The world's most-cited Plant Sciences journal

This article is part of the Research Topic

Serine Metabolism and Function in Plants

Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Plant Sci. | doi: 10.3389/fpls.2018.00972

Arabidopsis serine decarboxylase 1 (SDC1) in phospholipid and amino acid metabolism

  • 1Institute of Plant and Microbial Biology, Academia Sinica, Taiwan

Arabidopsis thaliana serine decarboxylase 1 (SDC1) catalyzes conversion of serine to ethanolamine, the first reaction step of phosphatidylcholine and phosphatidylethanolamine biosynthesis. However, an involvement of SDC1 in amino acid metabolism remains elusive despite that serine is the substrate of SDC1. Here, we showed that SDC1 localizes in mitochondria although phosphatidylcholine and phosphatidylethanolamine are known to be produced in the ER. Moreover, we found that overexpression of SDC1 decreased levels of amino acid compounds derived from mitochondrial tricarboxylic acid cycle. These results suggest that mitochondria-localized SDC1 plays an important role in both phospholipid and amino acid metabolism in A. thaliana.

Keywords: phospholipid biosynthesis, phospholipid, serine decarboxylase, Glycerolipid metabolism, Arabidopsis thaliana

Received: 27 Feb 2018; Accepted: 15 Jun 2018.

Edited by:

Roc Ros, Universitat de València, Spain

Reviewed by:

Masami Y. Hirai, RIKEN Center for Sustainable Resource Science (CSRS), Japan
Pierre CAROL, Université Pierre et Marie Curie, France  

Copyright: © 2018 Liu, Gunawan, Yunus and Nakamura. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Yuki Nakamura, Institute of Plant and Microbial Biology, Academia Sinica, Taipei, Taiwan, nakamura@gate.sinica.edu.tw