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Front. Plant Sci. | doi: 10.3389/fpls.2018.01697

Central roles and regulatory mechanisms of dual-specificity MAPK phosphatases in developmental and stress signaling

  • 1Institute of Tropical Agriculture and Forestry, Hainan University, China
  • 2Department of Biochemistry, University of Missouri, United States

Mitogen-Activated Protein Kinase (MAPK) cascades are conserved signaling modules that integrate multiple signaling pathways. One level of control on the activity of MAPKs is through their negative regulators, MAPK phosphatases (MKPs). Therefore, MKPs also play an integrative role for plants responding to diverse environmental stimulus; but the mechanism(s) by which these phosphatases contribute to specific signals remains largely unknown. In this review, we summarize recent advances in characterizing the biological functions of a sub-class of MKPs, dual-specificity phosphatases (DSPs), ranging from controlling plant growth and development to modulating stress adaptation. We also discuss putative regulatory mechanisms of DSP-type MKPs, which plants may use to control the correct level of responses at the right place and time. We highlight insights into potential regulation of cross-talk between different signaling pathways, facilitating the development of strategies for targeting such cross-talk and to help improve plant resistance against adverse environmental conditions without affecting the growth and development.

Keywords: mitogen-activated protein kinase, phosphatase, Regulatory mechanism, development, stress signaling

Received: 27 Aug 2018; Accepted: 31 Oct 2018.

Edited by:

Simone Ferrari, La Sapienza University of Rome, Italy

Reviewed by:

Saijaliisa Kangasjärvi, University of Turku, Finland
Alois Schweighofer, Universität Wien, Austria  

Copyright: © 2018 Jiang, Chen, Luo and Peck. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Dr. Lingyan Jiang, Institute of Tropical Agriculture and Forestry, Hainan University, Haikou, China, jly15873169162@163.com
Prof. Scott C. Peck, Department of Biochemistry, University of Missouri, Columbia, 65211, Missouri, United States, pecks@missouri.edu