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Front. Plant Sci. | doi: 10.3389/fpls.2018.01813

Pathway Editing Targets for Thiamine Biofortification in Rice Grains

  • 1University Institute of Engineering and Technology, Chandigarh, India

Over 2 billion people suffer from different types of malnutrition worldwide (WHO report, 2016). The role of vitamins in stress tolerance, growth and development has been reported in human and plants (Hellmann and Mooney, 2010; Galluzzi et al., 2013; Colinas and Fitzpatrick, 2015). Except vitamins B3 (niacin) and D, human body is incapable of synthesizing other vitamins. Because of high water solubility and heat sensitivity, majority of B-type vitamins and vitamin C are lost during cooking, resulting into their deficiency in diets. The average storage span of vitamin B1 in human body is only about 18 days and therefore, it needs to be replenished from diet regularly (Wooley et al., 2008). This review focuses on the enrichment of food grains with vitamin B1 (also called thiamine or aneurin), taking rice as the model crop and lays emphasis on pathway engineering through genome editing.

Keywords: biofortification, CRISPR, gene editing, Pathway, rice

Received: 15 Nov 2018; Accepted: 21 Nov 2018.

Edited by:

Frontiers I. Plant Science, Frontiers Media SA, Switzerland

Copyright: © 2018 MINHAS, TULI and Puri. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. ANU P. MINHAS, University Institute of Engineering and Technology, Chandigarh, Chandigarh, India,