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This article is part of the Research Topic

NAD Metabolism and Signaling in Plants

Hypothesis and Theory ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Plant Sci. | doi: 10.3389/fpls.2019.00681

Calmodulin is the fundamental regulator of NADK-mediated NAD signaling in plants

  • 1State Key Laboratory of Crop Stress Biology for Arid Areas, Northwest A&F University, China
  • 2Northwest A&F University, China

Calcium (Ca2+) signaling and nicotinamide adenine dinucleotide (NAD) signaling are two basic signal regulation pathways in organisms, playing crucial roles in signal transduction, energy metabolism, stress tolerance and various developmental processes. Notably, calmodulins (CaMs) and NAD kinases (NADKs) are important hubs for connecting these two types of signaling networks, where CaMs are the unique activators of NADKs. NADK is a key enzyme for NADP (including NADP+ and NADPH) biosynthesis by phosphorylating NAD (including NAD+ and NADH) and therefore, maintains the balance between NAD pool and NADP pool through an allosteric regulation mode. In addition, the two respective derivatives from NAD+ (substrate of NADK) and NADP+ (product of NADK), cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP), have been considered to be the important messengers for intracellular Ca2+ homeostasis which could finally influence the combination between CaM and NADK, forming a feedback regulation mechanism. In this review, we briefly summarized the major research advances related to the feedback regulation pathway, and provided new insights on the regulatory mechanism for CaM and NADK interactions during plant development and signaling. Furthermore, we genome-widely identified the members of wheat (Triticum aestivum L.) CaM family and initially proved the interactions between TaCaMs and TaNADKs at the molecular level, laying a foundation for further study in the regulation mechanism between CaMs and NADKs. All these results indicate that CaM is the fundamental regulator of NADK-mediated NAD signaling in plant development and stress response.

Keywords: Calmodulin (CAM), NAD kinase, NAD signaling, Regulation mechanism, Plants

Received: 27 Feb 2019; Accepted: 06 May 2019.

Edited by:

Alisdair Fernie, Max Planck Institute for Molecular Plant Physiology, Germany

Reviewed by:

Antony Galione, University of Oxford, United Kingdom
Eduardo A. Ceccarelli, CONICET Instituto de Biología Molecular y Celular de Rosario (IBR), Argentina  

Copyright: © 2019 Tai, Li, Nie, Zhang, Hu, Zhang, Liu, Li and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Kun-Ming Chen, Northwest A&F University, Yangling, China, kunmingchen@nwsuaf.edu.cn