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Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Plant Sci. | doi: 10.3389/fpls.2019.00693

Cytokinin transporters: Multisite players in cytokinin homeostasis and signal distribution

  • 1Biology Department, Brookhaven National Laboratory (DOE), United States

Cytokinins are a group of mobile adenine derivatives that act as chemical signals regulating a variety of biological processes implicated in plant development and stress responses. Their synthesis, homeostasis, and signaling perception evoke complicated intracellular traffic, intercellular movement, and in short- and long-distance translocation. Over nearly two decades, subsets of membrane transporters have been recognized and implicated in the transport of cytokinins as well as the related adenylates. In this review, we aim to recapitulate the key progresses in the exploration of the transporter proteins involved in cytokinin traffic and translocation, discuss their functional implications in the cytokinin-mediated paracrine and long-distance communication, and highlight some knowledge gaps and open issues toward comprehensively understanding the molecular mechanism of membrane transporters in controlling spatiotemporal distribution of cytokinin species.

Keywords: Cytokinin, ATP-binding cassette transporter, Purine permease, Equilibrative nucleoside transporter, isopentenyl adenine, Trans-zeatin

Received: 22 Jan 2019; Accepted: 08 May 2019.

Edited by:

Markus Geisler, Université de Fribourg, Switzerland

Reviewed by:

Thomas Schmülling, Freie Universität Berlin, Germany
Jan Hejatko, Central European Institute of Technology (CEITEC), Czechia  

Copyright: © 2019 Liu and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Chang-Jun Liu, Brookhaven National Laboratory (DOE), Biology Department, Ridge, 11973, NY, United States, cliu@bnl.gov