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Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Plant Sci. | doi: 10.3389/fpls.2019.00978

Ecological conditions and molecular determinants involved in Agrobacterium lifestyle in tumors

  • 1UMR5557 Ecologie Microbienne (LEM), France
  • 2Ecologie Microbienne, UMR CNRS 55557, UMR INRA 1418, VetAgro Sup, UCBL , Lyon , France, Université Claude Bernard Lyon 1, France
  • 3UMR Ecologie Microbienne, CNRS, INRA, VetAgro Sup, UCBL,, Université de Lyon, France
  • 4Laboratoire BAE-LBBM USR 3579 UPMC-CNRS, Université de Perpignan Via Domitia, France
  • 5Ecologie Microbienne, UMR CNRS 55557, UMR INRA 1418, VetAgro Sup, UCBL, Université Claude Bernard Lyon 1, France
  • 6UMR Ecologie Microbienne, CNRS, INRA, VetAgro Sup, UCBL, Université de Lyon, France

The study of pathogenic agents in their natural niches allows for a better understanding of disease persistence and dissemination. Bacteria belonging to the Agrobacterium genus are soil-borne and can colonize the rhizosphere. These bacteria are also well known as phytopathogens as they can cause tumors (crown-gall disease) by transferring a DNA region (T-DNA) into a wide range of plants. Most reviews on Agrobacterium are focused on virulence determinants, T-DNA integration, bacterial and plant factors influencing the efficiency of genetic transformation. Recent research papers have focused on the plant tumor environment on the one hand, and genetic traits potentially involved in bacterium-plant interactions on the other hand. The present review gathers current knowledge about the special conditions encountered in the tumor environment along with the Agrobacterium genetic determinants putatively involved in bacterial persistence inside a tumor. By integrating recent metabolomic and transcriptomic studies, we describe how tumors develop and how Agrobacterium can maintain itself in this nutrient-rich but stressful and competitive environment.

Keywords: Agrobacterium tumefaciens, Molecular traits, Crown-gall, Tumor lifestyle, competition, plant defense

Received: 21 Feb 2019; Accepted: 11 Jul 2019.

Edited by:

Essaid Ait Barka, Université de Reims Champagne-Ardenne, France

Reviewed by:

Sameh SELIM, UniLaSalle, France
Nemanja Kuzmanovic, Julius Kühn-Institut, Germany  

Copyright: © 2019 Meyer, Thiour-Mauprivez, Wisniewski-Dyé, Kerzaon, Comte, Vial and Lavire. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Céline Lavire, UMR5557 Ecologie Microbienne (LEM), Villeurbanne, 69622, Rhône-Alpes, France, celine.lavire@univ-lyon1.fr