DNA base excision repair in plants: an unfolding story with familiar and novel characters
- 1Departamento de Genética, Universidad de Córdoba, Spain
Base excision repair (BER) is a critical genome defense pathway that deals with a broad range of non-voluminous DNA lesions induced by endogenous or exogenous genotoxic agents. BER is a complex process initiated by the excision of the damaged base, proceeds through a sequence of reactions that generate various DNA intermediates, and culminates with restoration of the original DNA structure. BER has been extensively studied in microbial and animal systems, but knowledge in plants has lagged behind until recently. Results obtained so far indicate that plants share many BER factors with other organisms, but also possess some unique features and combinations. Plant BER plays an important role in preserving genome integrity through removal of damaged bases. However, it performs additional important functions, such as the replacement of the naturally modified base 5-methylcytosine with cytosine in a plant-specific pathway for active DNA demethylation.
Keywords: DNA Repair, DNA Damage, DNA glycosylase, AP endonuclease, Arabidopsis
Received: 05 Apr 2019;
Accepted: 30 Jul 2019.
Edited by:Alma Balestrazzi, University of Pavia, Italy
Reviewed by:Seiichi Toki, National Institute of Agrobiological Sciences, Japan
Ales Pecinka, Max Planck Institute for Plant Breeding Research, Germany
Copyright: © 2019 Roldan-Arjona, Ariza and Cordoba-Cañero. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Dr. Dolores Cordoba-Cañero, Departamento de Genética, Universidad de Córdoba, Córdoba, Spain, email@example.com