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Front. Plant Sci. | doi: 10.3389/fpls.2019.01479

Regulatory Mechanisms of Mitochondrial Autophagy: Lessons from Yeast

 Tomotake Kanki1*,  Kentaro Furukawa1 and Aleksei Innokentev1
  • 1Niigata University, Japan

Mitochondria produce the majority of ATP required by cells via oxidative phosphorylation. Therefore, regulation of mitochondrial quality and quantity is important for maintaining cellular activities. Mitophagy, the selective degradation of mitochondria, is thought to contribute to control of mitochondrial quality and quantity. In recent years, the molecular mechanism of mitophagy has been extensively studied in yeast and mammalian cells. In particular, identification of the mitophagy receptor Atg32 has contributed to substantial progress in understanding of mitophagy in yeast. This review summarizes the molecular mechanism of mitophagy in yeast and compares it to the mechanism of mitophagy in mammals. We also discuss the current understanding of mitophagy in plants.

Keywords: yeast, Atg32, CK2, Ppg1, FAR complex, Mitochondria, mitophagy

Received: 13 Sep 2019; Accepted: 25 Oct 2019.

Copyright: © 2019 Kanki, Furukawa and Innokentev. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Mx. Tomotake Kanki, Niigata University, Niigata, Japan, kanki@med.niigata-u.ac.jp