%A Shi,Huqing %A Wang,Xiang %A Yi,Jinyao %A Zhu,Xiongzhao %A Zhang,Xiaocui %A Yang,Juan %A Yao,Shuqiao %D 2015 %J Frontiers in Psychology %C %F %G English %K Major depressive disorder (MDD),Emotional faces processing,functional magnetic resonance imaging (fMRI),default mode network (DMN),independent component analysis (ICA) %Q %R 10.3389/fpsyg.2015.01198 %W %L %M %P %7 %8 2015-August-12 %9 Original Research %+ Prof Shuqiao Yao,Medical Psychological Institute, Second Xiangya Hospital, Central South University,Changsha, China,shuqiaoyao@163.com %+ Prof Shuqiao Yao,National Technology Institute of Psychiatry, Central South University,Changsha, China,shuqiaoyao@163.com %# %! DMN alternations during emotional task in MDD %* %< %T Default mode network alterations during implicit emotional faces processing in first-episode, treatment-naive major depression patients %U https://www.frontiersin.org/articles/10.3389/fpsyg.2015.01198 %V 6 %0 JOURNAL ARTICLE %@ 1664-1078 %X Previous studies have focused on resting-state default mode network (DMN) alterations in the development and maintenance of depression; however, only a few studies have addressed DMN changes during task-related processing and their results are inconsistent. Therefore, we explored DMN patterns in young adult patients with first-episode, treatment-naïve major depressive disorder (MDD) performing an implicit emotional processing task. Patients with MDD (N = 29) and healthy controls (N = 33) were subjected to functional magnetic resonance imaging (fMRI) at rest and while performing a gender judgment task. Group independent component analysis (ICA) was used to identify DMN component under task state for both groups. The DMN of participants with MDD had decreased functional connectivity in bilateral prefrontal areas compared to controls. Right prefrontal gyrus connectivity for MDD patients correlated negatively with scores on maladaptive scales of the Cognitive Emotion Regulation Questionnaire (CERQ). Our findings suggest that depressed people have altered DMN patterns during implicit emotional processing, which might be related to impaired internal monitoring and emotional regulation ability.