Correlation between dietary score and depression in cancer patients: Data from the 2005–2018 National Health and Nutrition Examination Surveys

Abstract

Aim:

To investigate the correlation between dietary score and depression in patients with cancer.

Methods:

In this cross-sectional study, data were collected from the National Health and Nutrition Examination Survey (NHANES) 2005–2018, a cross-sectional and nationally representative database, to compare 322 patients with depression to 2,868 with no depression. Mediterranean (MEDS) diet, Dietary Approaches to Stop Hypertension (DASH) diet, and the Healthy Eating Index 2015 (HEI-2015) score were calculated. Depression was assessed using the Patient Health Questionnaire-9 (PHQ-9). Weighted logistic regression models were used to explore the relationship between dietary scores and depression in patients with cancer. Subgroup analysis was performed by sleep disorders, sex, cancer type, number of tumors, and pain relief prescription treatment.

Results:

The final study sample included 3,190 adults, with 56.94% of them being women, representing 2,177 (86.51%) non-Hispanic white adults. After multivariable adjustment, the MEDS score was correlated with a reduced risk of depression in patients with cancer [odds ratio (OR): 0.90, 95% confidence interval (CI): 0.82–0.97, p = 0.010]. Moreover, the MEDS score was correlated with depression in cancer patients with sleep disorders (OR: 0.84, 95% CI: 0.76–0.93, p = 0.001), in female patients with cancer (OR: 0.83, 95% CI: 0.74–0.92, p < 0.001), particularly in female cancer reproductive system patients (OR: 0.69, 95% CI: 0.57–0.82, p < 0.001). MEDS score also showed a decreased risk of depression in patients with 1 cancer (OR: 0.90, 95% CI: 0.82–0.98, p = 0.019). MEDS score (OR: 0.86, 95% CI: 0.86–0.98, p = 0.024) and DASH (OR: 0.91, 95% CI: 0.84–0.98, p = 0.015) score were related to a decreased risk of depression in patients with cancer using pain relief prescription.

Conclusion:

Good diet quality is significantly correlated with decreased risk of depression in patients with cancer. Aligning with the Dietary Guidelines, such as the MEDS diet, may be beneficial to the reduced risk of depression in patients with cancer.

Introduction

Cancer is a major public health problem worldwide and is the second leading cause of death in the United States (Viale, 2020; Siegel et al., 2021). Although substantial improvements have been made in the clinical treatment of cancer, its overall prognosis remains unfavorable (Miller et al., 2019). As cancer has a substantial effect on patients' physical appearance, physical ability, family, occupation, economic status, and emotions during diagnosis and treatment (Le et al., 2018), depression becomes a common psychological disease that is comorbid with cancer (Akimana et al., 2019). Depression damages the immune system and promotes the progression of cancer, which leads to worse disease outcomes (Robson et al., 2017). Depression also increases patient treatment non-compliance, such as failure to attend consultation appointments, and leads to poorer treatment response (Erim et al., 2019). A better understanding of the influencing factors of depression among patients with cancer may not only prolong the lives of patients but also improve their quality of life.

Existing evidence based on the National Health and Nutrition Examination Survey (NHANES) has assessed the relationship between overall health and diet (Glover et al., 2022a). Several epidemiological studies have found a correlation between individual food types and nutrients (such as folic acid or omega-3 fatty acids) and the risk of depression (Sakai et al., 2017; Li et al., 2018; Rahimlou et al., 2018). While most of them focused on specific food intake (Lee et al., 2021; Steele et al., 2021). Many researchers also found that adherence to specific dietary patterns, such as the Mediterranean (MEDS) diet (Sánchez-Villegas et al., 2013), Dietary Approaches to Stop Hypertension (DASH) diet (Perez-Cornago et al., 2017), and the Healthy Eating Index 2015 (HEI-2015) score (Wang et al., 2021), was correlated with lower depression risk in non-cancer populations. However, there is extremely limited evidence about the correlation between diet scores and depression among patients with cancer. In order to alleviate the psychological stress of patients with cancer and reduce the impact of depression on the prognosis of patients with cancer, it is necessary to explore the correlation between dietary scores and depression in patients with cancer.

Herein, we conducted this study to explore whether the diet scores correlate with depression among patients with cancer and possibly provide dietary measures to reduce the risk of depression, improving the quality of life of patients with cancer.

Methods

Study design and participants

In this cross-sectional study, data were collected from the NHANES between 2005 and 2018. NHANES is a nationally representative, population-based survey for assessing adult and child health and nutritional status in the US. This survey combined health interviews conducted in respondents' homes with health measurements performed at mobile exam centers (MECs). The examination components consisted of medical, dental, and physiological measurements, and laboratory tests were supervised by trained medical personnel. Furthermore, the adoption of various modern equipment enabled the NHANES to collect reliable and high-quality data (Belladelli et al., 2021). Moreover, compensation and a report of medical findings were given to each participant, which increased the compliance of participants (National Health and Nutrition Examination Survey, 2020). This study included seven NHANES survey cycles (2005–2006, 2007–2008, 2009–2010, 2011–2012, 2013–2014, 2015–2016, and 2017–2018). Patients with no dietary information or a total intake of 0, patients with non-cancer, and patients with incomplete depression-related questionnaires were excluded. The sample consisted of 3,190 patients with a history of cancer. Only publicly available data were used in the study, and no ethical approval was needed in this study.

Definition and assessments

Recommendations from MEDS included (1) abundant use of olive oil for cooking and dressing; (2) increased consumption of fruit, vegetables, legumes, and fish; (3) reduction in total meat consumption and recommending white meat instead of red or processed meat; (4) preparation of homemade sauce with tomato, garlic, onion, and spices with olive oil to dress vegetables, pasta, rice, and other dishes; (5) avoidance of butter, cream, fast food, sweets, pastries, and sugar-sweetened beverages; and (6) for alcohol drinkers, moderate consumption of red wine (Sánchez-Villegas et al., 2013). The DASH-style dietary pattern includes reducing sodium and increasing potassium intake; moderating of alcohol intake; and increasing physical activity (American Diabetes Association., 2019). The HEI is a measure for assessing dietary quality, precisely, the degree to which a set of foods aligns with the Dietary Guidelines for Americans. The HEI-2015 components were the same as in the HEI-2010, except saturated fat and added sugars replaced empty calories, with the result being 13 components (Krebs-Smith et al., 2018). HEI-2015 scores ranged from 0 to 100, with higher HEI scores reflecting better diet quality. We utilized the total nutrient intakes on the first day (DR1TOT) to calculate the 13 components of HEI-2015. For further weighted Scott-Rao chi-square test and weighted logistic regressions, HEI-2015 scores of less than 50, between 50 and 70, and more than 70 were categorized as inadequate, average, and optimal, respectively (De La Cruz et al., 2021).

Depression was assessed using the Patient Health Questionnaire-9 (PHQ-9). The PHQ-9 is a well-validated (Cronbach's α = 0.89), self-report instrument that assesses depression symptoms (i.e., sadness, trouble sleeping, fatigue, and problems concentrating) in the past 2 weeks and has moderate concordance with clinical psychiatric interviews. The PHQ-9 questionnaire contains nine items, with each item being assessed on a four-point Likert scale, ranging from 0 = not at all to 3 = nearly every day, and summing up a total scale range of 0–27. A dichotomous variable indicating no depression (PHQ-9 score <10) or increased depressive symptoms (PHQ-9 score ≥ 10) was created using a threshold score of 10 (Kroenke et al., 2001).

Potential covariates

Potential covariates included age, sex (male and female), race (Mexican American, Other Hispanic, non-Hispanic white, non-Hispanic black, and other race, such as multi-racial), marital status (married, widowed, divorced/separated, and spinsterhood), body mass index (BMI) status (underweight and normal, overweight, and obesity), property income ratio (PIR), education status [ ≤ 11th grade, i.e., 12th grade with no diploma, high school graduate/general equivalency diploma (GED), some college or AA degree, and above], sleep disorder (yes and no), hypertension (yes and no), diabetes (yes and no), smoking status (yes and no), pain relief prescription use (yes and no), cancer types (breast cancer, cervix cancer, bladder cancer, colon cancer, kidney cancer, melanoma, ovary cancer, prostate cancer, skin cancer, and uterus cancer), and the number of tumors. PIR was categorized as ≤ 130%, >130–350%, and >350% by the ratio of family income to poverty (FPL).

Statistical analysis

Measurement data were expressed as mean ± standard error (SE), and comparisons between different groups were performed by Student's t-test. Classification variables were recorded as case numbers and percentages and compared between groups using a weighted chi-square test. NHANES data had a multi-stage stratified probability sampling design. The missing values were filled by multiple interpolations. The missing values before and after interpolation were compared between groups as sensitivity analysis.

A weighted between-group difference analysis was performed in a sample population with or without depression. We then fitted multivariable weight-adjusted logistic regression models to assess the relationship between dietary score and depression in patients with cancer across three models: model 1 was an unadjusted model; model 2 was adjusted for sex, age, and race; and model 3 was adjusted for all variables with statistical differences in univariate analysis. Subgroups of the population were analyzed based on the presence or absence of sleep disorders, sex, cancer of the female reproductive system, the number of tumors, and whether pain relievers were used.

Statistical analysis was performed using a two-sided test, and statistical significance was defined as p < 0.05. The annual percentage changes (APCs) were calculated using Rv3.6.3 (Institute for Statistics and Mathematics, Vienna, Austria), and trend tests were performed by using the Joinpoint Program 4.0.4. The Mecweight, strata (KSTRATA), and cluster (primary sampling unit, PSU) were used for weighted analysis. All other analyses were performed using SASv9.4 (SAS Institute Inc., Cary, NC, USA).

Results

Characteristics of included study

Figure 1 describes the study design, sampling, and exclusion; our final sample included 3,190 NHANES participants, with a mean age of 62.69 (0.35) years. There were 300 individuals in the depression group and 2,868 individuals without depression. Depression is more common in women (217; 68.45%) than men. Age, sex, race, marital status, BMI, PIR, education level, sleep disorder, smoking status, pain relief prescription use, cervix cancer, ovary cancer, uterus cancer, the number of tumors, and dietary scores were found to correlate with depression (Table 1). Figures 2, 3 respectively present the depression prevalence trend and mean dietary scores in our sample. From 2005 to 2017, there was no statistical difference in depression prevalence (APC: −1.8, 95% CI: −7.6 to 4.5, p = 0.490).

Figure 1

Figure 2

Figure 3

Correlation between MEDS, DASH, HEI 2015, and depression

From models 1 and 2, we could notice that MEDS, DASH, and HEI were all correlated with depression in patients with cancer. After adjusting for sex, age, race, smoking history, sleep disorders, education level, family poverty ratio, marital status, BMI, cervix cancer, ovary cancer, uterus cancer, pain medication use, and the number of different types of cancer, only MEDS showed a link to a decreased risk of depression in patients with cancer [odds ratio: (OR): 0.90, 95% confidence interval (CI): 0.82–0.97, p = 0.010]. The significant correlations between diet scores and depression are shown in Table 2.

Correlation between MEDs, DASH, HEI 2015, and depression among different population

The results of the subgroup analysis of sleep disorders suggested that MEDS scores were correlated with depression in cancer patients with sleep disorders (OR: 0.84, 95% CI: 0.76–0.93, p = 0.001; Table 3).

Based on sex subgroup analysis, we found that the MEDS (OR: 0.83, 95% CI: 0.74–0.92, p < 0.001) and the DASH (OR: 0.95, 95% CI: 0.91–0.99, p = 0.018) were correlated with a decreased risk of depression in female patients with cancer. Moreover, the MEDS pattern may lower the risk of depression in women than the DASH pattern with a standardized beta being −19.16 (Table 4).

According to the female reproductive system cancer subgroup analysis, MEDS diet (OR: 0.69, 95% CI: 0.57–0.82, p < 0.001), DASH (OR: 0.90, 95% CI: 0.84–0.96, p = 0.002), and HEI score (OR: 0.96, 95% CI: 0.93–0.99, p = 0.005) were all related to a lower risk of depression in female reproductive system patients with cancer. However, concerning standardized beta values, the MEDS diet was correlated with a lower risk of depression in women with female reproductive cancer (Table 5).

Regarding the number of tumors subgroup analysis, the MEDS score still was correlated with a decreased risk of depression in patients with only 1 cancer (OR: 0.90, 95% CI: 0.82–0.98, p = 0.019; Table 6).

Concerning whether or not to use pain relief prescription subgroup analysis and pain relief prescription use, MEDS score (OR: 0.86, 95% CI: 0.86–0.98, p = 0.024) and DASH (OR: 0.91, 95% CI: 0.84–0.98, p = 0.015) score decreased the risk of depression in patients with cancer using pain relief prescription (Table 7).

Discussion

Based on the NHANES database, several studies have assessed the impact of lifestyle on an individual's health (Del Giudice et al., 2021; Glover et al., 2022a,b). A growing body of research suggests a protective role of a good diet style against depression (Winpenny et al., 2018; Gibson-Smith et al., 2020; Oliván-Blázquez et al., 2021); nevertheless, evidence to evaluate this correlation among patients with cancer is scarce. In this study, we assessed the correlation between diet scores and depression among patients with cancer. From our findings, the MEDS score showed a link to a decreased risk of depression in patients with cancer. Moreover, MEDS score was correlated with depression in cancer patients with sleep disorders, in female patients with cancer, and particularly in female cancer reproductive system patients. MEDS score and DASH score also showed a decreased risk of depression in patients using pain relief prescriptions.

In this study, the MEDS score showed a link to a decreased risk of depression in patients with cancer. Increasing evidence implicates certain dietary patterns, such as higher intake of fruit, vegetables, and fish, as being beneficial to brain health (Hossain et al., 2020). The MEDs diet is receiving significant attention as regards its role in preserving cognitive health and protecting against depression (Román et al., 2019). This diet is typically characterized by higher intakes of fruit, vegetables, whole grains, fish, unsaturated fatty acids, and regular but moderate consumption of alcohol (Moore et al., 2018). Better post-diagnosis diet quality has been found to be associated with less cancer-related fatigue in breast cancer survivors (George et al., 2014). A study demonstrated that post-diagnosis diet quality was directly associated with subsequent mental and physical functioning in breast cancer survivors (Wayne et al., 2006). Diet quality may be an important factor influencing the manifestation of depressive symptoms in patients with cancer or conversely, poorer diet quality may be an outcome of depression. Thus, for patients with cancer, a healthy diet, such as the MEDS diet, may be beneficial to improve mental health, reduce the risk of depression, and improve life wellbeing.

Based on our subgroup analysis, MEDS scores were correlated with depression in female patients with cancer, particularly in female cancer reproductive system patients. Yin et al. (2021) found that higher adherence to a MEDS diet in middle age was associated with a lower risk of depression later in life among Swedish women. Wu et al. (2020) demonstrated that acid-producing diets were associated with depression; the correlations were stronger in women who had breast cancer diagnosed before age 55. Women with cancer of the reproductive system should pay more attention to a high-quality diet and eat more vegetables, fruits, whole grains, fish, and unsaturated fatty acids to reduce the risk of depression. In this study, we did not find a correlation between diet scores and depression risk in male patients with cancer. Differences in hormones between men and women may be a possible reason for this difference. A systematic review has found a correlation between male infertility and overall male health (Del Giudice et al., 2020).

In our findings, MEDS score and DASH score were associated with a decreased risk of depression in patients with cancer using pain relief prescriptions. A previous study showed a strong correlation between depression and cancer pain where the odds of having a major depression are more than 4 times higher in those with pain complaints (Alemayehu et al., 2018). Cancer pain is caused either directly by the tumor (primary tumor invasion or metastases) or indirectly by cancer treatments (surgery, chemotherapy, and radiotherapy) (Caraceni and Shkodra, 2019). A previous study (Maggi et al., 2019) assessing the psychological impact of different primary treatments for prostate cancer reported a mutual influence between functional and psychological modifications induced by treatments. Vartolomei et al. (2022) found that patients with small renal masses that underwent active surveillance seem to have a lower quality of life with respect to physical activity than their counterparts that underwent active treatment with some additional degree of psychological distress. The association between diet scores and depression in cancer patients with different treatments that include pain relief prescriptions needs further investigation.

There are several hypotheses regarding the possible etiological basis for this positive effect of the MEDs score on the risk of depression. Firstly, the high levels of antioxidants (fiber, β-carotenes, and vitamins A, C, D, and E) in fruits and vegetables have beneficial effects on depression (Sánchez-Villegas et al., 2015; Liu et al., 2016). Second, vitamin B6, vitamin B12, and folate are involved in neurochemical pathways, and the synthesis of monoamines, such as serotonin and noradrenaline, is related to the risk of depression (Sánchez-Villegas et al., 2009). Third, the gastrointestinal microbiome plays an important role in mental health. It is involved in two-way communication between the brain and the gastrointestinal tract via the gut-brain axis, which may be the fundamental link between the microbiome and depression (Taylor and Holscher, 2020). Dietary fiber deficiency leads to a significant loss of gut microbiome diversity and affects the function of gut bacteria (Cheung et al., 2019). It was subsequently reported that dietary fiber intake from fruits and vegetables was negatively associated with depressive symptoms (Cheung et al., 2019).

Some of the limitations of this article cannot be ignored. First, a correlation derived from this cross-sectional study does not necessarily indicate causality regarding the relationship between dietary patterns and depression in patients with cancer. Some mental illnesses might influence appetite and alter an individual's food choices; therefore, poor diet quality may be the result of mental health symptoms, rather than a causative factor. Second, we assessed depression with a self-report rating scale, rather than definite cases of depression based on a clinician-administered structured diagnostic interview. In addition, due to the limitations of the database, the time of diagnosis of the tumor and the severity of the tumor was not available. Prospective studies would be highly informative to further assess the association between diet scores and the risk of depression in patients with cancer.

Conclusions

Mediterranean score was correlated with a reduced risk of depression in patients with cancer. However, additional studies are required before the results can be generalized and clinical recommendations can be given.

Funding

This study was supported by Jiangsu Cancer Hospital 2021 Science and Technology Development Fund project truth-seeking clinical research special project (ZL202111).

Publisher's note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

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