Frontiers in Chemistry

Original Research

Published on 27 May 2025

Network pharmacology and molecular dynamics simulation reveal antineoplastic potential of Antarctic sponge-derived suberitenones

in Medicinal and Pharmaceutical Chemistry

Prasenjit Bhowmik
Rahul Mallick
Asim K. Duttaroy

Frontiers in Chemistry

doi 10.3389/fchem.2025.1545834

1,686 views

Original Research

Published on 27 May 2025

Functional and structural insights into the multicopper oxidase MmcO from Mycobacterium tuberculosis: implications for drug targeting

in Chemical Biology

Dafeng Liu
Feng Yu
Yihan Luo
Ayitunihe Hanate

Frontiers in Chemistry

doi 10.3389/fchem.2025.1565715

1,274 views

Review

Published on 26 May 2025

A review of combined imaging and therapeutic applications based on MNMs

in Nanoscience

Yiqing Yang
Peihong Teng
Shaonan Yu
Yuran Meng
Jinjie Zuo
He Guo
Guifeng Liu

Frontiers in Chemistry

doi 10.3389/fchem.2025.1595376

1,315 views

Original Research

Published on 22 May 2025

Design of novel pyrazole and benzofuran-based derivatives as potent acetylcholinesterase inhibitors for Alzheimer’s disease management

in Theoretical and Computational Chemistry

Mohamed El Fadili
Amine Ez-Zoubi
Mourad Aloui
Somdutt Mujwar
Hatem A. Abuelizz
Menana Elhalaoui
Adnan Amin

Frontiers in Chemistry

doi 10.3389/fchem.2025.1614462

3,469 views

Original Research

Published on 22 May 2025

Inhibitory effect of Fisetin against the aggregation process of SOD1 E100K mutant: computer-based drug design as a potential therapeutic for ALS disease

in Theoretical and Computational Chemistry

Fatemeh Sadat Seyedi Asl
Nasrin Malverdi
Fatemeh Sadat Ataei Kachouei
Fatemeh Zarei
Shamim Ghiabi
Payam Baziyar
Mohsen Nabi-Afjadi

Frontiers in Chemistry

doi 10.3389/fchem.2025.1569777

1,617 views

Original Research

Published on 21 May 2025

Synthesis and characterization of thymol-derived phenoxy acetamide derivatives using DFT, molecular docking, and parasitological investigations

in Medicinal and Pharmaceutical Chemistry

Ahmed R. Rabee
Saied M. Soliman
Hamida Abdel-Hamid
Esraa A. Moneer
Sara H. Akl
Yahya H. Shahin
Aliaa A. Masoud
Doaa Ahmad Ghareeb
Mariusz Jaremko
Abdul-Hamid Emwas

Frontiers in Chemistry

doi 10.3389/fchem.2025.1579923

12,119 views

Original Research

Published on 21 May 2025

Exploring the application of the microbial pigment violacein as a sustainable probe molecule for recycled paper-based SERS substrates

in Green and Sustainable Chemistry

Alessia Tropea
Donatella Spadaro
Dario Giuffrida
Sebastiano Trusso
Daniele Giuffrida
Tania Maria Grazia Salerno
Julio Montanez
Lourdes Morales-Oyervides
Luigi Mondello
Rosina Celeste Ponterio

Frontiers in Chemistry

doi 10.3389/fchem.2025.1571986

1,265 views

Correction

Published on 20 May 2025

Corrigendum: Viral mimicry as a design template for nucleic acid nanocarriers

in Nanoscience

Ina F. de la Fuente
Shraddha S. Sawant
Mark Q. Tolentino
Patrick M. Corrigan
Jessica L. Rouge

Frontiers in Chemistry

doi 10.3389/fchem.2025.1624509

734 views

Original Research

Published on 19 May 2025

Engineering of antimicrobial peptide Brevinin-1pl: arginine, lysine, and histidine substitutions enhance antimicrobial-anticancer efficacy with reduced cytotoxicity

in Medicinal and Pharmaceutical Chemistry

Jingkai Wang
Fanli Zeng
Xiaoling Chen
Tao Wang
Lei Wang
Mei Zhou
Yangyang Jiang
Tianbao Chen
Yongfei Fang
Jinwei Zhang

Frontiers in Chemistry

doi 10.3389/fchem.2025.1579097

2,596 views

Original Research

Published on 19 May 2025

GlycoIP: an integrated platform for simultaneous and site-specific N/O-glycosylation analysis of human semen

in Analytical Chemistry

Gaoshu Yan
Fei Cai
Keliang Wu
Qingyuan Cheng
Yong Zhang
Lin Fan

Frontiers in Chemistry

doi 10.3389/fchem.2025.1569561

1,199 views

Original Research

Published on 19 May 2025

H2 production in underground coal gasification with pretreatment by non-focusing microwave

in Green and Sustainable Chemistry

Lele Feng
Jie Dong
Haidong Li
Jiaxuan Sun

Frontiers in Chemistry

doi 10.3389/fchem.2025.1586267

892 views

Original Research

Published on 19 May 2025

Pore-scale numerical simulation of in situ microemulsion formation and enhanced oil recovery in porous media

in Green and Sustainable Chemistry

Yingxue Hu
Kai Dong
Dan Zhang
Tianjiang Wu
Wei Xu
Zhaolin Gu

Frontiers in Chemistry

doi 10.3389/fchem.2025.1601086

891 views

Original Research

Published on 15 May 2025

Computational modeling and thermal analysis of magnetized nanofluid flow with physio-chemical interaction and chemical reaction between two non-parallel walls

in Solid State Chemistry

Shahid Sohail
Zahir Shah
Muhammad Rooman
Waris Khan
Mansoor H. Alshehri
Narcisa Vrinceanu
Elisabeta Antonescu

Frontiers in Chemistry

doi 10.3389/fchem.2025.1466356

889 views

Review

Published on 14 May 2025

Advances in photocatalytic research on decarboxylative trifluoromethylation of trifluoroacetic acid and derivatives

in Photocatalysis and Photochemistry

Fang-Fang Tan
Zhan-Chao Li

Frontiers in Chemistry

doi 10.3389/fchem.2025.1602003

3,130 views

Original Research

Published on 13 May 2025

Chronic alcohol intake disrupts cytochrome P450 enzyme activity in alcoholic fatty liver disease: insights into metabolic alterations and therapeutic targets

in Medicinal and Pharmaceutical Chemistry

Qian Zhu
Xuefeng Xie
Ling Fang
Cheng Huang
Jun Li

Frontiers in Chemistry

doi 10.3389/fchem.2025.1509785

1,657 views

Original Research

Published on 12 May 2025

Identification of novel potential hypoxia-inducible factor-1α inhibitors through machine learning and computational simulations

in Medicinal and Pharmaceutical Chemistry

Yuxiang He
Shuning Diao
Shengzhen Hou
Taiying Li
Wenhui Meng
Jinping Zhang

Frontiers in Chemistry

doi 10.3389/fchem.2025.1585882

1,449 views