Frontiers in Immunology | Molecular Innate Immunity

Original Research

Published on 04 Aug 2025

The C-type lectin receptor Dcir (Clec4a2) restrains Aspergillus fumigatus elimination by limiting the degranulatory activity of neutrophils

in Molecular Innate Immunity

Fabio Seiti Yamada Yoshikawa
Rikio Yabe
Shota Torigoe
Sho Yamasaki
Shinobu Saijo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1639400

2,973 views

Original Research

Published on 01 Aug 2025

PLCγ2 controls neutrophil-like cell sensitivity through calcium oscillation and gates chemoattractant concentration range for chemotaxis

in Molecular Innate Immunity

Xuehua Xu
Woo Sung Kim
Arthur Lee
Tian Jin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1633390

2,113 views

Original Research

Published on 31 Jul 2025

Long-term hyperglycaemia exerts contrasting effects on M1- and M2-like macrophages

in Molecular Innate Immunity

Sona Margaryan
David Poghosyan
Susanna Ghonyan
Lina Hakobyan
Anush Martirosyan
Gayane Manukyan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1639650

2,413 views
3 citations

Original Research

Published on 30 Jul 2025

Transcriptional responses in different mouse models of septic liver injury differ from those in patients with septic liver injury

in Molecular Innate Immunity

Qin Yan
Wei Fan
Xinsen He
Shi Zheng
Xiaolin Zhong

Frontiers in Immunology

doi 10.3389/fimmu.2025.1556392

2,332 views
1 citation

Original Research

Published on 29 Jul 2025

RORα-activated mitophagy attenuating hypoxic-ischemic encephalopathy via suppression of microglial cGAS-STING axis

in Molecular Innate Immunity

Lei Song
Haiyan Shen
Fei Hong
Weiyan Zhang
Hongyi Lu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1592737

3,969 views
1 citation

Review

Published on 28 Jul 2025

The Role of SR-BI in sepsis: leveraging mechanistic insights to advance precision steroid therapy

in Molecular Innate Immunity

Ling Guo
Qian Wang
Xiang-An Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1643395

2,403 views
1 citation

Original Research

Published on 28 Jul 2025

Conserved function of bat TBK1 in activating innate immunity against RNA viruses: insights into the innate immune response in bats

in Molecular Innate Immunity

Qiuju Liu
Qi Shao
Caixia Xu
Chao Liu
Shuhan Li
Jie Wang
Xia Liu
Kehui Zhang
Yaxian Yan
Jianhe Sun

Frontiers in Immunology

doi 10.3389/fimmu.2025.1574866

2,320 views

Review

Published on 28 Jul 2025

Neutrophil extracellular traps and interleukin-1β in cystic fibrosis lung disease

in Molecular Innate Immunity

Kayla M. Fantone
Naveen Gokanapudi
Balázs Rada

Frontiers in Immunology

doi 10.3389/fimmu.2025.1595994

4,557 views
1 citation

Review

Published on 28 Jul 2025

Interactions between islet-resident macrophages and β cells in diabetes

in Molecular Innate Immunity

Danhuai Zhang
Lingzhe Meng
Minghui Xi
Shuai Li
Wantong Chen
LuYi Li
Lingling Dong
Na Wu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1630507

5,649 views
4 citations

Mini Review

Published on 25 Jul 2025

Harnessing innate immunity against glioblastoma microenvironment

in Molecular Innate Immunity

Wenbo Zhang
Wanhong Zhang
Henghao Wu
Xinsheng Han

Frontiers in Immunology

doi 10.3389/fimmu.2025.1648601

5,001 views
1 citation

Original Research

Published on 25 Jul 2025

Cannabidiol polarizes human neutrophils toward a cancer-promoting phenotype

in Molecular Innate Immunity

Mona Khoury
Yuxiang Hong
Dayana Blokon-Kogan
Stela Gengrinovitch
Harel Eitam
Moran Avraham-Kelbert
Hadas Weinstein-Marom
Peng Xu
Idan Cohen
Gil Bar-Sela

Frontiers in Immunology

doi 10.3389/fimmu.2025.1543403

3,374 views

Review

Published on 24 Jul 2025

The role of complement in normal pregnancy and preeclampsia

in Molecular Innate Immunity

Richard M. Burwick
Anuja Java
Jean F. Regal

Frontiers in Immunology

doi 10.3389/fimmu.2025.1643896

4,787 views
4 citations

Original Research

Published on 23 Jul 2025

Microglia exhibit a dynamic response, modulating inducible nitric oxide synthase expression and the production of pro-inflammatory cytokines during experimental cerebral malaria

in Molecular Innate Immunity

Lucas Freire-Antunes
Uyla Ornellas-Garcia
Marcos Rangel-Ferreira
Mônica Lucas Ribeiro-Almeida
Leonardo José Moura Carvalho
Cláudio Tadeu Daniel-Ribeiro
Flávia Lima Ribeiro-Gomes

Frontiers in Immunology

doi 10.3389/fimmu.2025.1494418

2,441 views

Original Research

Published on 22 Jul 2025

GSDMD-NETs in patients with sepsis-induced coagulopathy and their interaction with glycocalyx damage

in Molecular Innate Immunity

Xiaoxi Shan
Songmei Yu
Zhaoying Tang
Ping Yang
Lixia Dong

Frontiers in Immunology

doi 10.3389/fimmu.2025.1624128

3,026 views
1 citation

Review

Published on 22 Jul 2025

Immunomodulatory actions of tonifying polysaccharides: pharmacological effects, mechanisms and therapeutic applications

in Molecular Innate Immunity

Jin-Yu Li
Chang Yi
Meng-Qin Zhu
Yan-Feng Yuan
Guang Chen
Ning-Ning Qiu
Lei Shen
Li-Ya Song
Wen-Long Liu
Xi-Li Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1640679

4,185 views
6 citations

Original Research

Published on 18 Jul 2025

FBXL3 serves as a suppressor of regenerative myogenesis

in Molecular Innate Immunity

Wei He
Shiyuan Han
Yanming Wu
Min Chen
Ting Xue
Hua You
Ying Chang
Song-Bai Liu
Yi Sun
Yinjiang Tang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1575712

3,108 views

Original Research

Published on 18 Jul 2025

To reveal biomarkers related to macrophage and lactic acid metabolism in renal fibrosis and explore their mechanisms

in Molecular Innate Immunity

Chen Yong
Yongfei Yu
Yuan Wei
Guoshun Huang
Lianghui Shu
Kun Gao
Enchao Zhou

Frontiers in Immunology

doi 10.3389/fimmu.2025.1609903

3,050 views
1 citation

Original Research

Published on 18 Jul 2025

A multidimensional analysis of temporomandibular joint and ankle joint erosion in inflammatory arthritis

in Molecular Innate Immunity

Darja Andreev
Pauline Porschitz
Daniela Weidner
Rui Song
Matthias Weider
Georg Schett
Lina Gölz
Aline Bozec

Frontiers in Immunology

doi 10.3389/fimmu.2025.1560723

3,288 views

Editorial

Published on 17 Jul 2025

Editorial: Community series in the role of complement in health and disease, volume II

in Molecular Innate Immunity

Maciej Cedzyński
Thomas Vorup-Jensen
Marcin Okrój
Anna S. Świerzko

Frontiers in Immunology

doi 10.3389/fimmu.2025.1658763

1,676 views

Mini Review

Published on 16 Jul 2025

The role of peripheral innate immune cells in Alzheimer’s disease progression

in Molecular Innate Immunity

Yanchun Cao
Ke Tang
Pengcheng Ma
Run Zhang
Yani Yang
Tingting Li
Ying Zhang
Xiaoming Peng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1616939

5,654 views
3 citations

Original Research

Published on 16 Jul 2025

Protection against prolonged pneumococcal infection involves structural changes in C-reactive protein and subsequent binding to both phosphocholine and amyloids on the bacterial surface

in Molecular Innate Immunity

Alok Agrawal
Donald N. Ngwa
J. Paul Simons
Sanjay K. Singh

Frontiers in Immunology

doi 10.3389/fimmu.2025.1631409

2,022 views
1 citation

Original Research

Published on 10 Jul 2025

Spatiotemporal regulation of ventilator lung injury resolution by TGF-β1+ regulatory B cells via macrophage vesicle-nanotherapeutics

in Molecular Innate Immunity

Ren Jing
Xiaoting Liao
Jianlan Mo
Sheng He
Xianlong Xie
Zhaokun Hu
Linghui Pan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1635178

2,529 views
2 citations

Review

Published on 09 Jul 2025

The lactylation-macrophage interplay: implications for gastrointestinal disease therapeutics

in Molecular Innate Immunity

Xinzhen Che
Yixin Zhang
Xiqi Chen
Guangdong Xie
Jinling Li
Chengchao Xu
Chunhua Zhang
Yong Zhu
Xinyu Yang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1608115

9,212 views
5 citations

Mini Review

Published on 09 Jul 2025

Dopamine as an endogenous regulator of innate immunity in sepsis

in Molecular Innate Immunity

Haichao Wang
Rui Kang
Daolin Tang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1625368

3,651 views
1 citation

3,597 articles

articles

The C-type lectin receptor Dcir (Clec4a2) restrains Aspergillus fumigatus elimination by limiting the degranulatory activity of neutrophils

PLCγ2 controls neutrophil-like cell sensitivity through calcium oscillation and gates chemoattractant concentration range for chemotaxis

Long-term hyperglycaemia exerts contrasting effects on M1- and M2-like macrophages

Transcriptional responses in different mouse models of septic liver injury differ from those in patients with septic liver injury

RORα-activated mitophagy attenuating hypoxic-ischemic encephalopathy via suppression of microglial cGAS-STING axis

The Role of SR-BI in sepsis: leveraging mechanistic insights to advance precision steroid therapy

Conserved function of bat TBK1 in activating innate immunity against RNA viruses: insights into the innate immune response in bats

Neutrophil extracellular traps and interleukin-1β in cystic fibrosis lung disease

Interactions between islet-resident macrophages and β cells in diabetes

Harnessing innate immunity against glioblastoma microenvironment

Cannabidiol polarizes human neutrophils toward a cancer-promoting phenotype

The role of complement in normal pregnancy and preeclampsia

Microglia exhibit a dynamic response, modulating inducible nitric oxide synthase expression and the production of pro-inflammatory cytokines during experimental cerebral malaria

GSDMD-NETs in patients with sepsis-induced coagulopathy and their interaction with glycocalyx damage

Immunomodulatory actions of tonifying polysaccharides: pharmacological effects, mechanisms and therapeutic applications

FBXL3 serves as a suppressor of regenerative myogenesis

To reveal biomarkers related to macrophage and lactic acid metabolism in renal fibrosis and explore their mechanisms

A multidimensional analysis of temporomandibular joint and ankle joint erosion in inflammatory arthritis

Editorial: Community series in the role of complement in health and disease, volume II

The role of peripheral innate immune cells in Alzheimer’s disease progression

Protection against prolonged pneumococcal infection involves structural changes in C-reactive protein and subsequent binding to both phosphocholine and amyloids on the bacterial surface

Spatiotemporal regulation of ventilator lung injury resolution by TGF-β1+ regulatory B cells via macrophage vesicle-nanotherapeutics

The lactylation-macrophage interplay: implications for gastrointestinal disease therapeutics

Dopamine as an endogenous regulator of innate immunity in sepsis