Frontiers in Immunology | Systems Immunology

Review

Published on 02 Dec 2025

Glial-mediated immune modulation in glaucomatous neurodegeneration: mechanisms and therapeutic implications

in Systems Immunology

Fangwei Zong
Jiaxin You
Hong Wu
Xuerui Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1640110

1,659 views

Review

Published on 27 Nov 2025

Utilization of artificial intelligence in prostate cancer detection: a comprehensive review of innovations in screening and diagnosis

in Systems Immunology

Emad Rajih
Abdulaziz Bakhsh
Walaa M. Borhan
Saeed Awad M. Alqahtani

Frontiers in Immunology

doi 10.3389/fimmu.2025.1670671

2,439 views
1 citation

Original Research

Published on 26 Nov 2025

TCDCA inhibits pyroptosis to alleviate sepsis-related acute hepatic injury via activating TGR5

in Systems Immunology

Yang Yuexiang
Rong Zhiwei
Baitian Li
Wang Qing
Liu Chunzheng
Wang Zetian
Liao Lijun

Frontiers in Immunology

doi 10.3389/fimmu.2025.1706041

1,600 views
1 citation

Mini Review

Published on 25 Nov 2025

Mechanisms of synovial macrophage polarization in osteoarthritis pathogenesis and their therapeutic implications

in Systems Immunology

Kun Zhang
Zheng Wang
Jiaqi He
Liuru Lu
Wenshu Wang
Aiwei Yang
Huayi Xie
Linhui Huang
Yuying Huang
Ke Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1637731

2,593 views
1 citation

Review

Published on 24 Nov 2025

Functional roles of immune cells in osteoporosis

in Systems Immunology

Zhenqian Qi
Jiayi Luo
Zheng Xiao
Dazhi Yang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1698283

2,426 views

Mini Review

Published on 24 Nov 2025

Recent advances in gut microbiota metabolite regulation of hepatic pregnane X receptor

in Systems Immunology

Tong Lin
Yang Chen
Linquan Liu
Tiesong Wu
Yan Qian
Baofen Jin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1692684

2,386 views
1 citation

Editorial

Published on 19 Nov 2025

Editorial: Crosstalk: skin cells and immune cells in inflammatory skin diseases, volume 2

in Systems Immunology

Kazuhiko Yamamura
Akira Shiraishi
Emi Sato
Samuel Williams

Frontiers in Immunology

doi 10.3389/fimmu.2025.1739229

766 views

Original Research

Published on 19 Nov 2025

Comprehensive analysis of the role of diverse programmed cell death patterns in sepsis

in Systems Immunology

Xiaotongning Yu
Zihao Zhou
Jing Ma
Xiaonan Wang
Chunyu Zhao
Anqi Hou
Shuo Sun

Frontiers in Immunology

doi 10.3389/fimmu.2025.1685533

2,282 views

Original Research

Published on 18 Nov 2025

Trophic and temporal dynamics of macrophage biology in human inner ear organogenesis

in Systems Immunology

Yidi Deng
Boaz Ehiogu
Emilia Luca
Alain Dabdoub
Kim-Anh Lê Cao
Christine A. Wells
Bryony A. Nayagam

Frontiers in Immunology

doi 10.3389/fimmu.2025.1690583

2,025 views
1 citation

Review

Published on 05 Nov 2025

Mechanisms of aging in the cardiovascular system: challenges and opportunities

in Systems Immunology

Xiaoying Zhao
Xinyue Yang
Yumeng Lin
Ruolan Lei
Wei Ding
Xinying He
Ying Cao
Dechou Zhang
Ping Liu
Meirou Liang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1635736

2,573 views

Mini Review

Published on 05 Nov 2025

Decoding immune low-response states in sepsis: single-cell and 3D spatial transcriptomic insights into immunoparalysis

in Systems Immunology

Yulian Yang
Yi Zhang
Jingjing Wu
Yi Liu
Xianying Lei

Frontiers in Immunology

doi 10.3389/fimmu.2025.1696914

2,589 views

Hypothesis and Theory

Published on 05 Nov 2025

Antibodies and cryptographic hash functions: quantifying the specificity paradox

in Systems Immunology

Robert J. Petrella

Frontiers in Immunology

doi 10.3389/fimmu.2025.1585421

1,549 views

Original Research

Published on 04 Nov 2025

Athero-oncology perspective: identifying hub genes for atherosclerosis diagnosis using machine learning

in Systems Immunology

Liyan Zhao
Xuzhen Lv
Wen Chen
Xinru Li
Jie Zhou
Qi Ai
Qinhui Tuo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1616096

2,888 views
1 citation

Original Research

Published on 03 Nov 2025

Integrative pharmacovigilance and AI-based framework uncovers potential drug triggers in juvenile idiopathic arthritis

in Systems Immunology

Qiang Luo
Yuxiao Chen
Dawei Liu
Xinlin Wu
Jun Yang
Haiguo Yu
Hongmei Song
Junfeng Wu
Jingyi Zhao
Xuemei Tang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1653003

2,603 views

Original Research

Published on 31 Oct 2025

Microbiome and metabolomics analyses of the effect of heat-sensitive moxibustion on allergic rhinitis in rats

in Systems Immunology

Jun Xiong
Jianheng Li
Haiyan Xu
Yicheng Li
Lunbin Lu
Shuang Yang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1656060

2,428 views

Original Research

Published on 30 Oct 2025

Portfolio analysis of single-cell RNA-sequencing and transcriptomic data unravels immune cells and telomere-related biomarkers in sepsis

in Systems Immunology

Dan Chen
Xiyi Huang
Chun Wang
Cheng Zheng
Yunhao Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1638156

2,080 views

Original Research

Published on 29 Oct 2025

Comprehensive real-time metabolic profiling of peripheral blood mononuclear cells reveals important methodological considerations for immunometabolism research

in Systems Immunology

Michael Macleod
Fendi Pradana
Alex J. Wadley
Jonathan Barlow

Frontiers in Immunology

doi 10.3389/fimmu.2025.1676550

2,015 views

Review

Published on 28 Oct 2025

Immunometabolic regulation of disulfidptosis in orthopedic diseases: mechanistic heterogeneity and therapeutic targets

in Systems Immunology

Xiaoming Zhao
Chen Zhang
Lian Qu
Jun Gao
Shaobo Wu
Yilei Zhang
Yingang Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1647931

1,980 views
1 citation

Original Research

Published on 27 Oct 2025

Decoding the hypoxia-exosome-immune triad in OSA: PRCP/UCHL1/BTG2-driven metabolic dysregulation revealed by interpretable machine learning

in Systems Immunology

Weilong Ye
Yitian Yang
Feiju Chen
Xiaoxi Lin
Yunan Wang
Lianfang Du
Jingjing Pan
Weifeng Liao
Bainian Chen
Riken Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1587522

2,162 views

Original Research

Published on 24 Oct 2025

Establishment of prognostic signature based on neutrophil extracellular traps-related genes in acute myeloid leukemia: a bioinformatics analysis

in Systems Immunology

Zhenglei Shen
Jingying Zhu
Ni Luo
Lei Feng
Heng Yue
Liying Song
Kunmei Liu
Huaxian Li
Honghua Cao
Yeying Zhou

Frontiers in Immunology

doi 10.3389/fimmu.2025.1580750

2,227 views

Original Research

Published on 24 Oct 2025

A mathematical framework for human neutrophil state transitions inferred from single-cell RNA sequence data

in Systems Immunology

Gustaf Wigerblad
Jonathan Carruthers
Sumanta Ray
Thomas Finnie
Grant Lythe
Saumyadipta Pyne
Carmen Molina-París
Mariana J. Kaplan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1654015

2,134 views
1 citation

Correction

Published on 23 Oct 2025

Correction: Artificial intelligence-driven analysis of antibody and nucleic acid biomarkers for enhanced disease diagnostics

in Systems Immunology

Zihan Liu
Feng Zhu
Mei Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1727174

468 views

Original Research

Published on 22 Oct 2025

Integrative multi-omics identifies MEIS3 as a diagnostic biomarker and immune modulator in hypertrophic cardiomyopathy

in Systems Immunology

Jinchen He
Zehua Zhou
Dejun Kong
Heng Zhu
Chunmei Liu
Yuyuan Wang
Tianqi Wu
Jinfeng Chen
Yan Liao
Qi Wu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1675467

2,258 views

Original Research

Published on 22 Oct 2025

Differential gene expression profiling and machine learning-based discovery of key genetic markers in VTE and CKD

in Systems Immunology

Hui Li
Cai Lin
Junjie Kuang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1654673

2,177 views

545 articles

articles

Glial-mediated immune modulation in glaucomatous neurodegeneration: mechanisms and therapeutic implications

Utilization of artificial intelligence in prostate cancer detection: a comprehensive review of innovations in screening and diagnosis

TCDCA inhibits pyroptosis to alleviate sepsis-related acute hepatic injury via activating TGR5

Mechanisms of synovial macrophage polarization in osteoarthritis pathogenesis and their therapeutic implications

Functional roles of immune cells in osteoporosis

Recent advances in gut microbiota metabolite regulation of hepatic pregnane X receptor

Editorial: Crosstalk: skin cells and immune cells in inflammatory skin diseases, volume 2

Comprehensive analysis of the role of diverse programmed cell death patterns in sepsis

Trophic and temporal dynamics of macrophage biology in human inner ear organogenesis

Mechanisms of aging in the cardiovascular system: challenges and opportunities

Decoding immune low-response states in sepsis: single-cell and 3D spatial transcriptomic insights into immunoparalysis

Antibodies and cryptographic hash functions: quantifying the specificity paradox

Athero-oncology perspective: identifying hub genes for atherosclerosis diagnosis using machine learning

Integrative pharmacovigilance and AI-based framework uncovers potential drug triggers in juvenile idiopathic arthritis

Microbiome and metabolomics analyses of the effect of heat-sensitive moxibustion on allergic rhinitis in rats

Portfolio analysis of single-cell RNA-sequencing and transcriptomic data unravels immune cells and telomere-related biomarkers in sepsis

Comprehensive real-time metabolic profiling of peripheral blood mononuclear cells reveals important methodological considerations for immunometabolism research

Immunometabolic regulation of disulfidptosis in orthopedic diseases: mechanistic heterogeneity and therapeutic targets

Decoding the hypoxia-exosome-immune triad in OSA: PRCP/UCHL1/BTG2-driven metabolic dysregulation revealed by interpretable machine learning

Establishment of prognostic signature based on neutrophil extracellular traps-related genes in acute myeloid leukemia: a bioinformatics analysis

A mathematical framework for human neutrophil state transitions inferred from single-cell RNA sequence data

Correction: Artificial intelligence-driven analysis of antibody and nucleic acid biomarkers for enhanced disease diagnostics

Integrative multi-omics identifies MEIS3 as a diagnostic biomarker and immune modulator in hypertrophic cardiomyopathy

Differential gene expression profiling and machine learning-based discovery of key genetic markers in VTE and CKD