ORIGINAL RESEARCH article
Front. Plant Sci.
Sec. Plant Bioinformatics
Volume 16 - 2025 | doi: 10.3389/fpls.2025.1529326
Global analysis of transcription factors using both the reference genome and the multi-transcriptome of Akebia trifoliata reveals a sophisticated functional strategy
Provisionally accepted
- Sichuan Agricultural University, Ya'an, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
All the transcription factors (TFs) encoded by a genome collectively constitute a functional entity that closely regulates various life activities through mutual cooperation. Akebia trifoliata, which has great industrial and medicinal value, has significant potential as a model plant for use in perennial horticultural studies, and its TF repertoire must be comprehensively resolved. The TF repertoire of A. trifoliata consists of 1602 transcription factors from 56 families, revealing uneven chromosomal distributions and variations in gene structure, GC content, molecular weight, and evolutionary features such as duplication and selection strength. Functional annotation indicated that these TFs play diverse regulatory roles in various biological pathways, despite members within the same family often having similar functions. The expression profile data further supported the pleiotropic nature of many TFs, and their tissue-specific expression modules and functional enrichment were characterized.Notably, cooperative interactions were frequently observed within and across TF families, and some of these interactions were highly credible, as identified by co-expression analysis.Additionally, among all of them, variant sites were detected in 1473 TFs, whereas variant sites were not detected in 129 TFs. This comprehensive analysis offers valuable insights into the regulatory mechanisms of A. trifoliata, enhancing our understanding of TF interactions and their roles in the development and adaptability of this organism.
Keywords: Transcription Factors, Akebia trifoliata, TF Cooperation, regulatory network, Expression pattern
Received: 19 Nov 2024; Accepted: 05 Aug 2025.
Copyright: © 2025 Yang, Li, Zhong, Yang, Han, Yi, Li and Luo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Peigao Luo, Sichuan Agricultural University, Ya'an, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.