ORIGINAL RESEARCH article
Front. Plant Sci.
Sec. Plant Metabolism and Chemodiversity
Volume 16 - 2025 | doi: 10.3389/fpls.2025.1570411
This article is part of the Research TopicIn-Depth Interpretation of Critical Genomic Information Related to the Biosynthesis of Key Specialized (Secondary) Metabolism in Medicinal PlantsView all 12 articles
Metabolomic Adaptations and Genetic Polymorphism in Ecopopulations of Rhodiola linearifolia Boriss
Provisionally accepted
Nina V Terletskaya1,2*
Malika Erbay2,3
Oxana N Khapilina4Ainur S Turzhanova4Irina G Otradnykh5Irina A Sedina5Aigerim Mamirova2,3Nazym K Korbozova2,3Saule Magzumova4Kazhybek Ashimuly3,6
Nataliya Kudrina2,3Vitaly G Salnikov3,7- 1Institute of Genetics and Physiology, Almaty, Kazakhstan
- 2Faculty of Biology and Biotechnology, Al-Farabi Kazakh National University, Almaty, Kazakhstan
- 3Institute of Genetic and Physiology, Almaty, Kazakhstan
- 4National Center for Biotechnology, Astana, Kazakhstan
- 5Institute of Botany and Phytointroduction, Almaty, Kazakhstan
- 6Faculty of Chemistry, Al-Farabi Kazakh National University, Almaty, Kazakhstan
- 7Faculty of Geografy, Al-Farabi Kazakh National University, Al-Farabi, Almaty, Kazakhstan
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Rhodiola linearifolia Boriss. (R. linearifolia) has long been used in folk medicine; however, research on its resources is limited due to the species inaccessibility for collection, and its potential for cultivation has not been previously explored. Understanding the synthesis of its valuable metabolites, as well as the factors influencing their accumulation under natural conditions, remains a relevant research objective. In this study, the metabolome of various ecopopulations of R. linearifolia was analyzed, and the relationship between metabolomic variations and genetic polymorphism was investigated using inter-simple sequence repeat (ISSR) and inter-primer binding site (iPBS) markers. Several significant positive correlations (r = 0.50-0.89) were observed. Significant genetic and metabolomic differences were identified among ecopopulations. Notably, experimental confirmation was obtained showing that ecopopulations with higher genetic polymorphism exhibited a more diverse metabolomic profile. These findings contribute to a deeper understanding of the species' adaptation mechanisms and provide a foundation both for developing approaches to in situ conservation for R. linearifolia in situ in natural habitats, and optimizing introduction strategies for cultivation outside its natural range.
Keywords: R. linearifolia Boriss., ecopopulations, Metabolome, polymorphism, iPBS amplification profiling, ISSR amplification profiling
Received: 03 Feb 2025; Accepted: 30 May 2025.
Copyright: © 2025 Terletskaya, Erbay, Khapilina, Turzhanova, Otradnykh, Sedina, Mamirova, Korbozova, Magzumova, Ashimuly, Kudrina and Salnikov. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Nina V Terletskaya, Institute of Genetics and Physiology, Almaty, Kazakhstan
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