ORIGINAL RESEARCH article
Front. Plant Sci.
Sec. Plant Metabolism and Chemodiversity
Volume 16 - 2025 | doi: 10.3389/fpls.2025.1586984
This article is part of the Research TopicPlant Natural Products: Biosynthesis, Regulation, and FunctionView all 16 articles
Fungal inhibitory activity of the sesquiterpenoids isolated from Laggera pterodonta
Provisionally accepted
- 1Yunnan Agricultural University, Kunming, China
- 2Yunnan Dehong Institute of Tropical Agriculture Science, Dehong, Yunnan, China
- 3State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan Province, China
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Phytochemical diversity in plants represents a valuable reservoir for novel agrochemical agents. Our preliminary investigations identified pronounced antifungal efficacy in Laggera pterodonta extracts, though this species remains critically understudied. Herein, six eudesmane-type sesquiterpenes (1-6) were isolated from L. pterodonta and structurally characterized through spectroscopic analysis. Additionally, we have evaluated anti-fungal activity of these compounds against six plant pathogenic fungus species: Phytophthora nicotianae, Fusarium oxysporum, Alternaria alternata, Gloeosporium frucrigenum Berk, Colletotrichum fructicola, Botrytis cinerea. The results showed that the six compounds exhibited varying degrees of inhibitory effects on the six plant pathogens. Compound 1 showed the strongest anti-fungal effect in a dose-dependent way, with EC50 values of 12.56 μg/mL, 51.29 μg/mL and 47.86 μg/mL against P. nicotianae, F. oxysporum and G. frucrigenum Berk, respectively. Compound 3 and compound 6 also showed notable inhibitory effects on F. oxysporum and P. nicotianae at 100 μg/mL, with inhibition rates of 58.82% and 73.92%, respectively. The MIC of compound 1 against P. nicotianae and F. oxysporum were 200 μg/mL and 400 μg/mL, respectively. Mechanistic analysis revealed that compound 1 induced pronounced ultra-structural deformations in P. nicotianae and F. oxysporum, compromising membrane integrity and elevating permeability in both pathogens.Notably, the three bioactive compounds exhibited favorable ADMET (absorption, distribution, metabolism, excretion, toxicity) profiles, demonstrating promising candidacy as novel herbicidal agents. These findings underscore their potential to advance phytogenic fungicide discovery.
Keywords: Laggera pterodonta, Antibacterial activity, Eudesmane-type sesquiterpenes, Phytophthora nicotianae, Fusarium oxysporum
Received: 03 Mar 2025; Accepted: 12 Jun 2025.
Copyright: © 2025 Liu, Li, Wu, Wu, Zhao, Ding and Qin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xiao Ding, State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan Province, China
Xiaoping Qin, Yunnan Agricultural University, Kunming, China
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