REVIEW article
Front. Plant Sci.
Sec. Plant Pathogen Interactions
Volume 16 - 2025 | doi: 10.3389/fpls.2025.1602573
This article is part of the Research TopicAdvancing Plant Defense: Genome Editing, RNAi, and Synthetic Biology for Sustainable Pest ControlView all 6 articles
Fostering plant protection against certain bacterial diseases through quorum-sensing signal molecules: A critical review
Provisionally accepted
- 1Hainan University, Haikou, China
- 2Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan Province, China
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Quorum sensing (QS) and clustered regularly interspaced short palindromic repeats (CRISPR) systems are envisaged as revolutionary in abating plant bacterial pathogens. Bacterial cell-cell communication and plant pathogens QSSMs (Quorum sensing signalling molecules) are dissected for underlying mechanisms in prominent pathogens viz., Pseudomonas syringae, Erwinia amylovora and Xanthomonas campestris. Biofilm formation and virulence mechanisms are critically addressed to repurpose potential QS inhibition strategies. CRISPR technologies are combined with CRISPR engineering to produce enhanced disease-resistant varieties, with potential applications. QS-CRISPR interplay for deciphering the key interactive changes in plant health management is prioritized for deliberate future research outcomes. Sustainable agricultural practices are envisaged for successful lab-to-field authentic field trials and large-scale applicability across the globe. Potential technical limitations, the need for stringent agricultural laws, and future innovations are addressed. Moreover, the cost-effectiveness, enhanced crop production, yield and productivity hindering the above key plant bacterial pathogens are comprehensively addressed against these plant bacterial pathogens. Furthermore, a future outlook characterized by extensive outreach and global implications is substantiated regardless of regional specificity, climate change, and global warming. A decade of research on advancements in adequate plant protection is revisited to incorporate augmented approaches, including artificial intelligence (AI) and machine learning, in sustainable agriculture. The significance of the present review is based on addressing QSSMs and plant protection strategies encompassing modern molecular biological techniques.
Keywords: Plant bacterial pathogens, Virulence, QS systems, CRISPR-Cas technology, QS-CRISPR interplay, QS inhibitors, Holistic plant health
Received: 30 Mar 2025; Accepted: 06 Oct 2025.
Copyright: © 2025 ANWAR, Vinothkanna and Jia. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
MUHAMMAD ANWAR, 184370@hainanu.edu.cn
Aiqun Jia, aqjia@muhan.edu.cn
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